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Re: County Seasonal flu alert (Influenza in Japan)
Yahoo translation:
< January bulletin of >2009, AH1 sub- type and the AH3 sub- type where separation is continued from the inspection body which was picked with the medical institution of Sendai city Yamagata city & Fukuoka city, this season of the B type influenza virus about the alienation of antigenicity from vaccine stocks
In order this season to be moved aside from the medical institution of Sendai city, Yamagata city and Fukuoka city influenza, because the result of analyzing the antigenicity of the influenza virus which is separated making use of the MDCK cell from the clinical inspection body of the patient, AH3 sub- type and the AH1 sub- type which are separated, either of the B type viruses you can see the tendency where antigenicity differs from vaccine stocks largely in, it reports.
Previous (2008) year December - book (2009) year separation and antigenicity of influenza virus of inspection body origin of medical institution of 3 cities to the 4th week middle
It did the antigenicity for the separated virus, all national infection symptom laboratories (the infection research) the ferret antiserum for the vaccine stocks of distribution and the red corpuscle cohesion control which uses 1.0% guinea pig blood corpuscle (HI) with test.
AH1 sub- type virus: With system of our HI tests as for homo- value of the vaccine stocks antigen for the antibody of infection research distribution 1: 640 is. Vis-a-vis this, the majority of separated virus 61 stocks of former Sendai medical institution origin, 1: 80 - 160 and 2 - 3 tubes to be lower than homo- value, in 1: 40 and 1: 20 (each 1 stocks) with, largely there were also some which have slipped. In addition, virus 11 stocks of the Fukuoka medical institution origin which is separated so far all HI values 1: 80 was, had slipped largely. Furthermore, these do not react vis-a-vis the antiserum for a/SOLOMON stocks which are AH1 sub- form chin stocks of last year completely (1: <10).
AH3 sub- type virus: With system of our HI tests homo- value of the vaccine stocks antigen for the antibody of infection research distribution is the 1:1,280. Vis-a-vis this, as for 4 stocks in 6 stocks of Sendai which is separated so far HI value 1: With 640, it has reacted with the antiserum for A/Uruguay/716/2007 which this season is vaccine stocks well, but as for 2 stocks 1: 160 and 1: The somewhat gap has occurred in 320 and antigenicity. On the one hand, with the virus of the Fukuoka medical institution origin, as for the inside 1 stocks of isolate 8 stocks 1: 80 it could recognize the big gap, but as for 7 stocks almost antigenicity agreed.
B type virus: With system of our HI tests as for homo- value of the vaccine stocks antigen for the antibody of infection research distribution, with the antiserum for B/Brisbane/3/2007 which is the Yamagata systematic reference virus 1: With the antiserum for B/Malaysia/2506/2004 which 2,560 is, is the Victoria systematic virus 1: 5,120 is.
Vis-a-vis this, as for the virus of the Yamagata medical institution origin which is separated so far there were 5 stocks, the everything of that was Yamagata systematic stocks, but the antigenicity the HI value 1:320 - 640 (respectively 1 stocks and 4 stocks) with, had the gap of 2 - 3 tubes. Furthermore, these did not react to the antiserum for B/Malaysia of B type Victoria system completely (1: <10).
On the one hand, B type virus 2 stocks are separated from the inspection body of the Fukuoka medical institution origin so far. Also 2 stocks were Victoria system, but it had changed from B/Malaysia where in each case HI value is, 80 is standard stocks largely. Furthermore, these did not react to the antiserum for Venn B/Bliss of B type Yamagata system completely (1: <10).
Consideration
To presently, nationwide AH3 sub- type and AH1 sub- type, separation of the B type virus almost 2: 2: Like 1 but 1), in Miyagi prefecture separation of the AH1 sub- type virus was the majority, Yamagata prefecture at the beginning separation of AH3 sub- type and B type was reported, but recently separation of AH1 sub- type has become main current. Presently in Fukuoka city three way state of popularity of AH3 sub- type, AH1 sub- type and B type is suggested from record of virus separation of medical institution origin of Fukuoka city which on the one hand, we start from this year 1st week.
Because the point where it is thought that in such, in the future it should note, is two you express below.
Popularity of 1.B type: The isolate at the area which with the latest analysis, you call Yamagata and Fukuoka and is far geographically was shown, having divided into the respective Yamagata system and Victoria system. Being the both, to come antigenicity of standard stocks “to slip”, from rather large thing, depending upon the method of spreading the future popularity of this season, because it produces the effect which is large to the selection of domestic vaccine stocks of season, virus stocks surveillance furthermore becomes important.
Meaning of the supervision for the antigenicity of the 2.AH1 sub- type virus: Presently, 2 where the majority of a/H1N1 virus stocks where the virus which had the gene of [oserutamibiru] tolerance even in Japan is separated has been occupied) thing on clinical site has become big topic, because of this, as for use of [oserutamibiru] for a type influenza, on clinical site there is a tendency which refrains. But, according to the present data, as for antigenicity of the AH1 sub- type virus which is in the midst of becoming popular because it matches the antigenicity of the vaccine, 2 where it is assumed that effectiveness of vaccination is expected,). But, with the latest our analysis, in Sendai and, always so it was suggested in Fukuoka that is not. Depending, in the future, prevention of the influenza and when thinking of remedy, at nationwide level investigation in addition to the investigation of antigenicity of the AH1 sub- type isolate, concerning the clinical effect of the influenza vaccine is necessary and also, concerning medicine tolerance not only genotype and the active inhibitor resistance of NA, whether or not the same medicine clinically is invalid, it is thought that there is a necessity which is investigated urgently concerning.
Reference
1) National infection symptom laboratory home page, influenza popularity level map 2nd week
2) IASR influenza bulletin article, http://idsc.nih.go.jp/iasr/rapid/pr3483.html National hospital mechanism Sendai medical center clinical division of research virus center
Hidekazu Nishimura Youko [hu] seeing child Itoh Chiba Akira Omi Mitiko Okamoto
The same pediatrics your Taoka paragraph child rice field 澤 Yuusaku
The same breathing apparatus internal medicine Saito Wakana Miki 祐
Yukio pediatrics Nagai Nagai, internal medicine Shoji Shoji 眞 (or more Sendai city)
Victory island pediatrics victory island Humio (Yamagata city)
Lawn clinic lawn tail Kiyouko, pediatrics Shin rattan quiet raw and Takasaki pediatrics Takasaki good raw, ashamedly it is be tired pediatrics Yamashita 祐 two (or more Fukuoka city)
Yahoo translation:
< January bulletin of >2009, AH1 sub- type and the AH3 sub- type where separation is continued from the inspection body which was picked with the medical institution of Sendai city Yamagata city & Fukuoka city, this season of the B type influenza virus about the alienation of antigenicity from vaccine stocks
In order this season to be moved aside from the medical institution of Sendai city, Yamagata city and Fukuoka city influenza, because the result of analyzing the antigenicity of the influenza virus which is separated making use of the MDCK cell from the clinical inspection body of the patient, AH3 sub- type and the AH1 sub- type which are separated, either of the B type viruses you can see the tendency where antigenicity differs from vaccine stocks largely in, it reports.
Previous (2008) year December - book (2009) year separation and antigenicity of influenza virus of inspection body origin of medical institution of 3 cities to the 4th week middle
It did the antigenicity for the separated virus, all national infection symptom laboratories (the infection research) the ferret antiserum for the vaccine stocks of distribution and the red corpuscle cohesion control which uses 1.0% guinea pig blood corpuscle (HI) with test.
AH1 sub- type virus: With system of our HI tests as for homo- value of the vaccine stocks antigen for the antibody of infection research distribution 1: 640 is. Vis-a-vis this, the majority of separated virus 61 stocks of former Sendai medical institution origin, 1: 80 - 160 and 2 - 3 tubes to be lower than homo- value, in 1: 40 and 1: 20 (each 1 stocks) with, largely there were also some which have slipped. In addition, virus 11 stocks of the Fukuoka medical institution origin which is separated so far all HI values 1: 80 was, had slipped largely. Furthermore, these do not react vis-a-vis the antiserum for a/SOLOMON stocks which are AH1 sub- form chin stocks of last year completely (1: <10).
AH3 sub- type virus: With system of our HI tests homo- value of the vaccine stocks antigen for the antibody of infection research distribution is the 1:1,280. Vis-a-vis this, as for 4 stocks in 6 stocks of Sendai which is separated so far HI value 1: With 640, it has reacted with the antiserum for A/Uruguay/716/2007 which this season is vaccine stocks well, but as for 2 stocks 1: 160 and 1: The somewhat gap has occurred in 320 and antigenicity. On the one hand, with the virus of the Fukuoka medical institution origin, as for the inside 1 stocks of isolate 8 stocks 1: 80 it could recognize the big gap, but as for 7 stocks almost antigenicity agreed.
B type virus: With system of our HI tests as for homo- value of the vaccine stocks antigen for the antibody of infection research distribution, with the antiserum for B/Brisbane/3/2007 which is the Yamagata systematic reference virus 1: With the antiserum for B/Malaysia/2506/2004 which 2,560 is, is the Victoria systematic virus 1: 5,120 is.
Vis-a-vis this, as for the virus of the Yamagata medical institution origin which is separated so far there were 5 stocks, the everything of that was Yamagata systematic stocks, but the antigenicity the HI value 1:320 - 640 (respectively 1 stocks and 4 stocks) with, had the gap of 2 - 3 tubes. Furthermore, these did not react to the antiserum for B/Malaysia of B type Victoria system completely (1: <10).
On the one hand, B type virus 2 stocks are separated from the inspection body of the Fukuoka medical institution origin so far. Also 2 stocks were Victoria system, but it had changed from B/Malaysia where in each case HI value is, 80 is standard stocks largely. Furthermore, these did not react to the antiserum for Venn B/Bliss of B type Yamagata system completely (1: <10).
Consideration
To presently, nationwide AH3 sub- type and AH1 sub- type, separation of the B type virus almost 2: 2: Like 1 but 1), in Miyagi prefecture separation of the AH1 sub- type virus was the majority, Yamagata prefecture at the beginning separation of AH3 sub- type and B type was reported, but recently separation of AH1 sub- type has become main current. Presently in Fukuoka city three way state of popularity of AH3 sub- type, AH1 sub- type and B type is suggested from record of virus separation of medical institution origin of Fukuoka city which on the one hand, we start from this year 1st week.
Because the point where it is thought that in such, in the future it should note, is two you express below.
Popularity of 1.B type: The isolate at the area which with the latest analysis, you call Yamagata and Fukuoka and is far geographically was shown, having divided into the respective Yamagata system and Victoria system. Being the both, to come antigenicity of standard stocks “to slip”, from rather large thing, depending upon the method of spreading the future popularity of this season, because it produces the effect which is large to the selection of domestic vaccine stocks of season, virus stocks surveillance furthermore becomes important.
Meaning of the supervision for the antigenicity of the 2.AH1 sub- type virus: Presently, 2 where the majority of a/H1N1 virus stocks where the virus which had the gene of [oserutamibiru] tolerance even in Japan is separated has been occupied) thing on clinical site has become big topic, because of this, as for use of [oserutamibiru] for a type influenza, on clinical site there is a tendency which refrains. But, according to the present data, as for antigenicity of the AH1 sub- type virus which is in the midst of becoming popular because it matches the antigenicity of the vaccine, 2 where it is assumed that effectiveness of vaccination is expected,). But, with the latest our analysis, in Sendai and, always so it was suggested in Fukuoka that is not. Depending, in the future, prevention of the influenza and when thinking of remedy, at nationwide level investigation in addition to the investigation of antigenicity of the AH1 sub- type isolate, concerning the clinical effect of the influenza vaccine is necessary and also, concerning medicine tolerance not only genotype and the active inhibitor resistance of NA, whether or not the same medicine clinically is invalid, it is thought that there is a necessity which is investigated urgently concerning.
Reference
1) National infection symptom laboratory home page, influenza popularity level map 2nd week
2) IASR influenza bulletin article, http://idsc.nih.go.jp/iasr/rapid/pr3483.html National hospital mechanism Sendai medical center clinical division of research virus center
Hidekazu Nishimura Youko [hu] seeing child Itoh Chiba Akira Omi Mitiko Okamoto
The same pediatrics your Taoka paragraph child rice field 澤 Yuusaku
The same breathing apparatus internal medicine Saito Wakana Miki 祐
Yukio pediatrics Nagai Nagai, internal medicine Shoji Shoji 眞 (or more Sendai city)
Victory island pediatrics victory island Humio (Yamagata city)
Lawn clinic lawn tail Kiyouko, pediatrics Shin rattan quiet raw and Takasaki pediatrics Takasaki good raw, ashamedly it is be tired pediatrics Yamashita 祐 two (or more Fukuoka city)
</TD></TR></TBODY></TABLE><!-- /写真エリア/ --> 県内で１月中にインフルエンザ（集団風邪）により、学校、学年、学級閉鎖を実施した施設は１月２９日現 在で、延べ３０施設となった。県健康増進課によると、２００６年からの４年間では最多。
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