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[h=1]Zhou Yusen team discovered a new mechanism of human infection with pathogenic H7N9 avian influenza virus[/h] [h=4][/h] 
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[FONT=宋] People infected with pathogenic H7N9 virus was discovered a new mechanism
[FONT=宋] Science and Technology Daily Beijing January 19 (by Shen Fei Chen Dong base), Institute of Microbiology and Epidemiology, Academy of Military Medical Zhou Yusen team Experimental Animal Center, the hospital had a joint forest team, Li Yan, Institute of Basic Medical team, Fudan University, Shanghai Shi Jiang Bo team and Germany Inflarx Gmbh company's chief scientist Guo Renfeng scientific research team, discovered a new mechanism of human infection with pathogenic H7N9 avian influenza virus. The virus is spread by infection, can lead to a class of human immune proteins - excessive activation of the complement system, causing acute lung injury. They Based on this discovery, new therapeutic strategies through an antibody for the anaphylatoxin C5a complement molecule drugs to regulate the level of expression, shown to greatly reduce the "inflammatory factors storm", significantly reduced lung pathological injury, which can effectively treatment of severe pneumonia caused by a viral infection. The results were published in the international field of infectious disease research authoritative latest issue of the academic journal "Clinical Infectious Diseases." THE ACADEMY papers and co-first author Dr. Zhao Guangyu played an important role in this study.[/FONT]
[FONT=宋] Complement is present in serum and tissue fluid in the heat of a class of a group of proteins with enzymatic activity. Early in the 19th century, human scientists confirmed that the blood contains a heat-labile components, can assist and supplement specific antibodies, immune-mediated lysis, hemolysis, so called complement. Complement is composed of more than 30 kinds of soluble proteins, membrane-bound proteins and complement receptor molecule composed of multi-system, it is called the complement system. Complement in the human body plays an important immune and physiological function, when some of the factors that led to their abnormal expression will cause disease damage.[/FONT]
[FONT=宋] Zhou Yusen research team showed that the complement-mediated immune pathological damage has played a very important "catalyst" role in the pathogenesis of severe pneumonia process. Therefore, the use of targeted strategies to suppress the immune therapy can effectively complement the treatment of severe pneumonia caused by a viral infection, to alleviate the patient's condition, to save the lives of patients has opened up a new path.
http://scitech.people.com.cn/n/2015/0120/c1007-26415000.html
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[FONT=宋]Shen Fei Chen Dong base[/FONT]
[h=5]At 08:39 on January 20, 2015 Source: China Science and Technology Network - Science and Technology Daily News phone watch[/h] Print Network Abstract Correction Mall Share Recommend Font size
Original title: Zhou Yusen team found that people infected with H7N9 bird flu virus, a new pathogenic mechanism[FONT=宋] People infected with pathogenic H7N9 virus was discovered a new mechanism
[FONT=宋] Science and Technology Daily Beijing January 19 (by Shen Fei Chen Dong base), Institute of Microbiology and Epidemiology, Academy of Military Medical Zhou Yusen team Experimental Animal Center, the hospital had a joint forest team, Li Yan, Institute of Basic Medical team, Fudan University, Shanghai Shi Jiang Bo team and Germany Inflarx Gmbh company's chief scientist Guo Renfeng scientific research team, discovered a new mechanism of human infection with pathogenic H7N9 avian influenza virus. The virus is spread by infection, can lead to a class of human immune proteins - excessive activation of the complement system, causing acute lung injury. They Based on this discovery, new therapeutic strategies through an antibody for the anaphylatoxin C5a complement molecule drugs to regulate the level of expression, shown to greatly reduce the "inflammatory factors storm", significantly reduced lung pathological injury, which can effectively treatment of severe pneumonia caused by a viral infection. The results were published in the international field of infectious disease research authoritative latest issue of the academic journal "Clinical Infectious Diseases." THE ACADEMY papers and co-first author Dr. Zhao Guangyu played an important role in this study.[/FONT]
[FONT=宋] Complement is present in serum and tissue fluid in the heat of a class of a group of proteins with enzymatic activity. Early in the 19th century, human scientists confirmed that the blood contains a heat-labile components, can assist and supplement specific antibodies, immune-mediated lysis, hemolysis, so called complement. Complement is composed of more than 30 kinds of soluble proteins, membrane-bound proteins and complement receptor molecule composed of multi-system, it is called the complement system. Complement in the human body plays an important immune and physiological function, when some of the factors that led to their abnormal expression will cause disease damage.[/FONT]
[FONT=宋] Zhou Yusen research team showed that the complement-mediated immune pathological damage has played a very important "catalyst" role in the pathogenesis of severe pneumonia process. Therefore, the use of targeted strategies to suppress the immune therapy can effectively complement the treatment of severe pneumonia caused by a viral infection, to alleviate the patient's condition, to save the lives of patients has opened up a new path.
http://scitech.people.com.cn/n/2015/0120/c1007-26415000.html
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