tetano
Editor, Senior Moderator
World J Pediatr
. 2022 May 4.
doi: 10.1007/s12519-022-00552-2. Online ahead of print.
Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study
Fatma Devrim[SUP] 1 [/SUP], Elif Böncüoğlu[SUP] 2 [/SUP], Elif Kıymet[SUP] 2 [/SUP], Şahika Şahinkaya[SUP] 2 [/SUP], Ela Cem[SUP] 2 [/SUP], Mine Düzgöl[SUP] 2 [/SUP], Aybüke Akaslan Kara[SUP] 2 [/SUP], Kamile Ötiken Arıkan[SUP] 2 [/SUP], Aslı Kantar[SUP] 1 [/SUP], Ebru Yılmaz[SUP] 1 [/SUP], Nida Dinçel[SUP] 1 [/SUP], Nuri Bayram[SUP] 2 [/SUP], İlker Devrim[SUP] 3 [/SUP]
Affiliations
Abstract
Background: There are limited numbers of studies focusing on renal effects of coronavirus disease 2019 (COVID-19) infection and proximal tubular dysfunction in children with COVID-19 infections. The purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confirmed acute COVID-19.
Methods: The children who were hospitalized for confirmed COVID-19 were included in this prospective descriptive analysis. The presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury: abnormal tubular reabsorption of phosphate, normoglycemic glycosuria, hyperuricosuria, and proteinuria.
Results: A total of 115 patients were included in the study. About a third of the individuals had elevated blood creatinine levels or proteinuria. In addition, abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10 (8.7%) patients, as was hyperuricosuria in 28.6%. As a result, total proximal tubular dysfunction was found in 24 (20.9%) patients.
Conclusions: One in every five children with acute COVID-19 infections had proximal tubular dysfunction, according to our data. Although, the rate of proximal tubular dysfunction was lower than in adults, it should be noted. The recovery of proximal tubular function in children with COVID-19 should be followed.
Keywords: Coronavirus disease 2019 (COVID-19); Proteinuria; Proximal tubular dysfunction; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Tubular reabsorption of phosphate.
. 2022 May 4.
doi: 10.1007/s12519-022-00552-2. Online ahead of print.
Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study
Fatma Devrim[SUP] 1 [/SUP], Elif Böncüoğlu[SUP] 2 [/SUP], Elif Kıymet[SUP] 2 [/SUP], Şahika Şahinkaya[SUP] 2 [/SUP], Ela Cem[SUP] 2 [/SUP], Mine Düzgöl[SUP] 2 [/SUP], Aybüke Akaslan Kara[SUP] 2 [/SUP], Kamile Ötiken Arıkan[SUP] 2 [/SUP], Aslı Kantar[SUP] 1 [/SUP], Ebru Yılmaz[SUP] 1 [/SUP], Nida Dinçel[SUP] 1 [/SUP], Nuri Bayram[SUP] 2 [/SUP], İlker Devrim[SUP] 3 [/SUP]
Affiliations
- PMID: 35505147
- DOI: 10.1007/s12519-022-00552-2
Abstract
Background: There are limited numbers of studies focusing on renal effects of coronavirus disease 2019 (COVID-19) infection and proximal tubular dysfunction in children with COVID-19 infections. The purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confirmed acute COVID-19.
Methods: The children who were hospitalized for confirmed COVID-19 were included in this prospective descriptive analysis. The presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury: abnormal tubular reabsorption of phosphate, normoglycemic glycosuria, hyperuricosuria, and proteinuria.
Results: A total of 115 patients were included in the study. About a third of the individuals had elevated blood creatinine levels or proteinuria. In addition, abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10 (8.7%) patients, as was hyperuricosuria in 28.6%. As a result, total proximal tubular dysfunction was found in 24 (20.9%) patients.
Conclusions: One in every five children with acute COVID-19 infections had proximal tubular dysfunction, according to our data. Although, the rate of proximal tubular dysfunction was lower than in adults, it should be noted. The recovery of proximal tubular function in children with COVID-19 should be followed.
Keywords: Coronavirus disease 2019 (COVID-19); Proteinuria; Proximal tubular dysfunction; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Tubular reabsorption of phosphate.