• FluTrackers.com Inc. does not provide medical advice. Information on this web site is collected from various internet resources, and the FluTrackers board of directors makes no warranty to the safety, efficacy, correctness or completeness of the information posted on this site by any author or poster. The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. Every individual reader or poster should seek advice from their personal physician/healthcare practitioner before considering or using any interventions that are discussed on this website. By continuing to access this website you agree to consult your personal physican before using any interventions posted on this website, and you agree to hold harmless FluTrackers.com Inc., the board of directors, the members, and all authors and posters for any effects from use of any medication, supplement, vitamin or other substance, device, intervention, etc. mentioned in posts on this website, or other internet venues referenced in posts on this website.
  • We are not asking for any donations. Do not donate to any entity who says they are raising funds for us.

WHO-H5N1 Monthly Risk Assessment Summary Summary and assessment as of 10 December 2013

B

Biological

Closed. Please see Biological100
Summary and assessment as of 10 December 2013
Human infection with avian influenza A(H5N1) viruses
From 2003 through 10 December 2013, 648 laboratory-confirmed human cases with avian influenza A(H5N1) virus infection have been officially reported to WHO from 15 countries. Of these cases, 384 died.
Since the last WHO Influenza at the Human Animal Interface update on 7 October 2013, seven new laboratory-confirmed human cases of influenza A(H5N1) virus infection were reported to WHO from Cambodia (6) and Indonesia (1).
In Cambodia, the reported incidence of human cases has increased in 2013 (26 cases in 2013 compared with 21 cases from 2005 through December 2012). This might be due to improvements in surveillance and physician awareness or to a potential increased circulation of the virus in poultry. The case fatality rate among reported cases, however, has decreased (54% in 2013 compared with 90% over all previous years).
Before 2013, H5N1 viruses from clade 1.1 predominated in Cambodia. Analysis of isolates from human cases and birds from the beginning of 2013 revealed the emergence of a new H5N1 genotype resulting from the reassortment of clade 1.1 and clade 2.3.2.1 viruses.
The link between the emergence of this reassortant virus and the increase in human cases observed in 2013 is yet to be determined.1
All seven human cases reported in this summary are considered to be sporadic, with no evidence of community-level transmission. As influenza A(H5N1) virus is thought to be circulating widely in poultry in Cambodia and Indonesia, additional sporadic human cases or small clusters might be expected in these countries in the future.

V Duong et al, A new genotype resulting from the reassortment of clade 1.1 and 2.3.2.1 at the origin of the human and animal H5N1 virus cases in Cambodia in 2013; http://optionsviii.controlinfluenza.com/optionsviii/assets/File/Options_VIII_Abstracts_2013.pdf, accessed 28 Nov 2013

Table 1: Laboratory-confirmed human cases of avian influenza A(H5N1) virus infection (7 October 2013 ? 10 December 2013)
Country Province AgeSex Date of onset Date of Hospitalisation Oseltamivir treatment Start date Date of death Exposure to
Cambodia Kampong Thom 8 F 08/10/2013 11/10/2013 14/10/2013 NA Dead poultry
Battambang 6 F 14/10/2013 19/10/2013 24/10/2013 NA Dead poultry
Pursat 2 F 17/10/2013 24/10/2013 NA 26/10/2013 Under investigation
Kampot 10 M 28/10/2013 07/11/2013 07/11/2013 09/11/2013 Dead chicken
Kampong Speu 3 M 05/11/2013 08/11/2013 08/11/2013 NA Sick and dead poultry
Pailin 29M 26/10/2013 03/11/2013 06/11/2013 06/11/2013 Sick and dead poultry
Indonesia West Java 31 F 01/11/20131 6/11/2013 NA 11/11/2013 Pet bird, poultry in neighbourhood, market and pigeons

NA: not applicable or not available
Overall public health risk assessment for avian influenza A(H5N1) viruses: Whenever influenza viruses are circulating in poultry, sporadic infections or small clusters of human cases are possible, especially


Figure 1: Epidemiological curve of avian influenza A(H5N1) cases in humans by country and month of onset

......

http://www.who.int/influenza/human_...nza_Summary_IRA_HA_interface_16December13.pdf
 
WHO: Summary and assessment as of 10 December 2013 Human infection with avian influenza A(H5N1) viruses

WHO: Summary and assessment as of 10 December 2013 Human infection with avian influenza A(H5N1) viruses

Summary and assessment as of 10 December 2013 Human infection with avian influenza A(H5N1) viruses

From 2003 through 10 December 2013, 648 laboratory-confirmed human cases with avian influenza A(H5N1) virus infection have been officially reported to WHO from 15 countries. Of these cases, 384 died.

Since the last WHO Influenza at the Human Animal Interface update on 7 October 2013, seven new laboratory-confirmed human cases of influenza A(H5N1) virus infection were reported to WHO from Cambodia (6) and Indonesia (1).

In Cambodia, the reported incidence of human cases has increased in 2013 (26 cases in 2013 compared with 21 cases from 2005 through December 2012). This might be due to improvements in surveillance and physician awareness or to a potential increased circulation of the virus in poultry. The case fatality rate among reported cases, however, has decreased (54% in 2013 compared with 90% over all previous years).
Before 2013, H5N1 viruses from clade 1.1 predominated in Cambodia. Analysis of isolates from human cases and birds from the beginning of 2013 revealed the emergence of a new H5N1 genotype resulting from the reassortment of clade 1.1 and clade 2.3.2.1 viruses.
The link between the emergence of this reassortant virus and the increase in human cases observed in 2013 is yet to be determined.1
All seven human cases reported in this summary are considered to be sporadic, with no evidence of community-level transmission. As influenza A(H5N1) virus is thought to be circulating widely in poultry in Cambodia and Indonesia, additional sporadic human cases or small clusters might be expected in these countries in the future.

V Duong et al, A new genotype resulting from the reassortment of clade 1.1 and 2.3.2.1 at the origin of the human and animal H5N1 virus cases in Cambodia in 2013; http://optionsviii.controlinfluenza.com/optionsviii/assets/File/Options_VIII_Abstracts_2013.pdf, accessed 28 Nov 2013

Table 1: Laboratory-confirmed human cases of avian influenza A(H5N1) virus infection (7 October 2013 ? 10 December 2013)
Country Province AgeSex Date of onset Date of Hospitalisation Oseltamivir treatment Start date Date of death Exposure to
Cambodia Kampong Thom 8 F 08/10/2013 11/10/2013 14/10/2013 NA Dead poultry
Battambang 6 F 14/10/2013 19/10/2013 24/10/2013 NA Dead poultry
Pursat 2 F 17/10/2013 24/10/2013 NA 26/10/2013 Under investigation
Kampot 10 M 28/10/2013 07/11/2013 07/11/2013 09/11/2013 Dead chicken
Kampong Speu 3 M 05/11/2013 08/11/2013 08/11/2013 NA Sick and dead poultry
Pailin 29M 26/10/2013 03/11/2013 06/11/2013 06/11/2013 Sick and dead poultry
Indonesia West Java 31 F 01/11/20131 6/11/2013 NA 11/11/2013 Pet bird, poultry in neighbourhood, market and pigeons

NA: not applicable or not available
Overall public health risk assessment for avian influenza A(H5N1) viruses: Whenever influenza viruses are circulating in poultry, sporadic infections or small clusters of human cases are possible, especially


Figure 1: Epidemiological curve of avian influenza A(H5N1) cases in humans by country and month of onset

......

http://www.who.int/influenza/human_...nza_Summary_IRA_HA_interface_16December13.pdf
 
Re: WHO-H5N1 Monthly Risk Assessment Summary Summary and assessment as of 10 December 2013

Duplicate post ,,, please remove!
 
Re: WHO-H5N1 Monthly Risk Assessment Summary Summary and assessment as of 10 December 2013

WHO and WPRO reports date of Hospitalisation for the 2-year-old girl from Pursat as the 24/10/2013 while the Joint news release between the Ministry of Health of the Kingdom of Cambodia and the World Health Organization, 23rd new human case of avian influenza H5N1 in Cambodia in 2013 on the 5 November 2013 reports the 25/10/2013

Clip:
The Ministry of Health (MoH) of the Kingdom of Cambodia wishes to advise members of the public that one new human case of avian influenza has been confirmed for the H5N1 virus. This is the 23rd case this year and the 44th person to become infected with the H5N1 virus in Cambodia. The 23rd case died on 26th October 2013. Of the 44 confrrmed cases, 33 were children under 14, and 27 of the 44 were female. In addition, only 11 cases out of the 23 cases this year survived.

The 23rd case, a 2-year-old girl from Svay Chrum village, Borng Bort Kandal commune, Bakane district, Pursat province was confirmed positive for H5N1 human avian influenza on 30th October 2013 by Institut Pasteur du Cambodge. The girl developed fever on 17th October 2013. On 19th October 2013, her parents sought treatment for her at a local private practitioner. Her condition worsened and she was admitted to Jayavarman VII Hospital in Siem Reap on 25th October 2013 with fever, running nose, lethargy, dyspnea, cough and breathing difficulties. Laboratory samples were taken the same day, but no Tamifu was administered. The girl died on the 26th October 2013. ......Read more

http://www.cdcmoh.gov.kh/PressRelease/44_Press_release_Eng.pdf

WPRO reports in Avian Influenza Weekly Update Number 407 (8 November 2013)
Clip:
Cambodia

The twenty-third case is a 2 year old female from SvayChrum village, BorngBortKandal commune, Bakane district, Pursat province, with fever onset on 17, was admitted to Jayavarman VII Hospital on 24 October. No Tamiflu was administered. The girl died on 26 October. No direct exposure to sick or dead chickens was reported, but investigations regarding exposure are ongoing.

(The twenty-second case is a 6 year old female from Phnom Preuk Dostrict, Battambang Province, with fever onset on 14 October, admitted to the Jayavarman VII Hospital, and was given Tamiflu on 24 October. Poultry had recently died at the girl’s neighbours’ houses in the village and also in nearby villages. The twenty-first case is an 8 years old female from O-Raing village, Pung Ror commune, Baray district in Kampong Thom province. Onset was 10 October 2013 and currently in stable condition. The case had a direct contact with dead poultry at home.)

http://www.wpro.who.int/emerging_diseases/AI.Weekly.407.08Nov2013.pdf

Country: Cambodia
Province: Pursat
Age: 2
Sex: Female
Date of onset: 17/10/2013
Date of Hospitalisation: 24/10/2013 [edt. ? 25-Oct-13]
Oseltamivir treatment Start date: N/A
Date of death: 26/10/2013
Exposure to: Under investigation

Flu trackers also has the 25-Oct-13....

-------

Table 1: Laboratory-confirmed human cases of avian influenza A(H5N1) virus infection (26 August 2013 – 7 October 2013)

Country: Cambodia
Province: Kampong Thom
Age: 8
Sex: Female
Date of onset: 08/10/2013
Date of Hospitalisation: 11/10/2013
Oseltamivir treatment Start date: 14/10/2013
Date of death: N/A
Exposure to: Dead poultry

Country: Cambodia
Province: Battambang
Age: 6
Sex: Female
Date of onset: 14/10/2013
Date of Hospitalisation: 19/10/2013
Oseltamivir treatment Start date: 24/10/2013
Date of death: N/A
Exposure to: Dead poultry

Country: Cambodia
Province: Pursat
Age: 2
Sex: Female
Date of onset: 17/10/2013
Date of Hospitalisation: 24/10/2013
Oseltamivir treatment Start date: N/A
Date of death: 26/10/2013
Exposure to: Under investigation

Country: Cambodia
Province: Kampot
Age: 10
Sex: Male
Date of onset: 28/10/2013
Date of Hospitalisation: 07/11/2013
Oseltamivir treatment Start date: 07/11/2013
Date of death: 09/11/2013
Exposure to: Dead chicken

Country: Cambodia
Province: Kampong Speu
Age: 3
Sex: Male
Date of onset: 05/11/2013
Date of Hospitalisation: 08/11/2013
Oseltamivir treatment Start date: 08/11/2013
Date of death: NA
Exposure to: Sick and dead poultry

Country: Cambodia
Province: Pailin
Age: 29
Sex: Male
Date of onset: 26/10/2013
Date of Hospitalisation: 03/11/2013
Oseltamivir treatment Start date: 06/11/2013
Date of death: 06/11/2013
Exposure to: Sick and dead poultry

---

Country: Indonesia
Province: West Java
Age: 31
Sex: Female
Date of onset: 01/11/20131
Date of Hospitalisation: 6/11/2013
Oseltamivir treatment Start date: N/A
Date of death: 11/11/2013
Exposure to: Pet bird, poultry in neighbourhood, market and pigeons


http://www.who.int/influenza/human_...nza_Summary_IRA_HA_interface_16December13.pdf
 
Re: WHO-H5N1 Monthly Risk Assessment Summary Summary and assessment as of 10 December 2013

Options for the Control of Influenza VIII Cape Town, South Africa 5-10 September 2013
http://optionsviii.controlinfluenza.com/


P1-239 (Evolution, Systems Biology,and Pathogenesis pg 183)

A new genotype resulting from the reassortment of clade 1.1 and 2.3.2.1 at the
origin of the human and animal H5N1 virus cases in Cambodia in 2013

V Duong1, S Rith1, SV Horm1, S Ly2, S Sorn3, S Chuop4, S Buth4, R Tsuyuoka5, D Laurent6, B
Richner6, H Seng2, B Sar7, D Holl3, P Kitsutani8, S Ung4, A Tarantola1, T Sok2, P Buchy1*
1Institut Pasteur in Cambodia, Phnom Penh, Cambodia; 2Communicable Disease Department,
Ministry of Health, Phnom Penh, Cambodia; 3National Veterinary Research Institute, Ministry of
Agriculture, Phnom Penh, Cambodia; 4National Institute of Public Health, Phnom Penh,
Cambodia; 5World Health Organization, Phnom Penh, Cambodia; 6Kantha Bopha Hospitals
Foundation, Phnom Penh, Cambodia; 7Centers for Disease Control and Prevention, Cambodia office,
Phnom Penh, Cambodia; 8Centers for Disease Control and Prevention, Atlanta, Georgia, United
States

Background: In Cambodia since 2004, A(H5N1) virus has been detected in 39 poultry outbreaks and
32 patients (27 deaths) to May 1, 2013. Until 2012, all A(H5N1) strains isolated in Cambodia
belonged to clades 1 and 1.1, of which six distinct lineages were identified. Lineage 1 viruses shared
the same ancestor with viruses from Thailand, while all the lineages detected since 2005 were closely
related to viruses detected in Southern Vietnam.

Materials and Methods: Samples were obtained
between January and March 2013. The samples comprised 10 confirmed human cases, 6 poultry
outbreak investigations and samples from environmental surveillance of live poultry markets. All
samples included in this study tested positive for A(H5N1) virus by real-time RT-PCR. Full genome
sequences were generated from 31 strains amplified after inoculation into MDCK cells, embryonated
eggs, or directly from the original specimen. Phylogenetic analyses were performed using the
maximum likelihood method on all the genes. Antigenic analyses were also performed using
reference antisera.

Results: The phylogenetic analysis of 8 genes revealed that the 31 A(H5N1)
strains isolated and sequenced in Cambodia in 2013 resulted from reassortment between clade 1.1
and clade 2.3.2.1 viruses. While the HA and NA genes belong to the clade 1.1, genotype Z, the 6
internal genes are closely related to the viruses of the clade 2.3.2.1 (A/Hubei/1/2011-like). Antigenic
analysis demonstrated a significant antigenic drift.

Conclusions: In this study we report the emergence
of a new genotype of clade 1.1 A(H5N1) virus in Cambodia associated with a significant antigenic
drift. The link between the emergence of this new genotype and the increase in human cases
observed in 2013 is yet to be determined.

http://optionsviii.controlinfluenza.com/optionsviii/assets/File/Options_VIII_Abstracts_2013.pdf
 
You must log in or register to reply here.
Back
Top Bottom