tetano
Editor, Senior Moderator
Viruses
. 2021 Jul 14;13(7):1362.
doi: 10.3390/v13071362.
The Mechanism behind Influenza Virus Cytokine Storm
Yinuo Gu[SUP] 1 [/SUP], Xu Zuo[SUP] 1 [/SUP], Siyu Zhang[SUP] 1 [/SUP], Zhuoer Ouyang[SUP] 1 [/SUP], Shengyu Jiang[SUP] 1 [/SUP], Fang Wang[SUP] 1 [/SUP], Guoqiang Wang[SUP] 1 [/SUP]
Affiliations
Abstract
Influenza viruses are still a serious threat to human health. Cytokines are essential for cell-to-cell communication and viral clearance in the immune system, but excessive cytokines can cause serious immune pathology. Deaths caused by severe influenza are usually related to cytokine storms. The recent literature has described the mechanism behind the cytokine-storm network and how it can exacerbate host pathological damage. Biological factors such as sex, age, and obesity may cause biological differences between different individuals, which affects cytokine storms induced by the influenza virus. In this review, we summarize the mechanism behind influenza virus cytokine storms and the differences in cytokine storms of different ages and sexes, and in obesity.
Keywords: age; cytokine storm; influenza virus; obesity; sex.
. 2021 Jul 14;13(7):1362.
doi: 10.3390/v13071362.
The Mechanism behind Influenza Virus Cytokine Storm
Yinuo Gu[SUP] 1 [/SUP], Xu Zuo[SUP] 1 [/SUP], Siyu Zhang[SUP] 1 [/SUP], Zhuoer Ouyang[SUP] 1 [/SUP], Shengyu Jiang[SUP] 1 [/SUP], Fang Wang[SUP] 1 [/SUP], Guoqiang Wang[SUP] 1 [/SUP]
Affiliations
- PMID: 34372568
- DOI: 10.3390/v13071362
Abstract
Influenza viruses are still a serious threat to human health. Cytokines are essential for cell-to-cell communication and viral clearance in the immune system, but excessive cytokines can cause serious immune pathology. Deaths caused by severe influenza are usually related to cytokine storms. The recent literature has described the mechanism behind the cytokine-storm network and how it can exacerbate host pathological damage. Biological factors such as sex, age, and obesity may cause biological differences between different individuals, which affects cytokine storms induced by the influenza virus. In this review, we summarize the mechanism behind influenza virus cytokine storms and the differences in cytokine storms of different ages and sexes, and in obesity.
Keywords: age; cytokine storm; influenza virus; obesity; sex.