tetano
Editor, Senior Moderator
Viruses
. 2023 Apr 19;15(4):1008.
doi: 10.3390/v15041008. Structural Consequences of Antigenic Variants of Human A/H3N2 Influenza Viruses
David Francis Burke[SUP] 1 [/SUP]
Affiliations
The genetic basis of antigenic drift of human A/H3N2 influenza virus is crucial to understanding the constraints of influenza evolution and determinants of vaccine escape. Amino acid changes at only seven positions near the receptor binding site of the surface hemagglutinin protein have been shown to be responsible for the major antigenic changes for over forty years. Experimental structures of HA are now available for the majority of the observed antigenic clusters of A/H3N2. An analysis of the HA structures of these viruses reveals the likely consequences of these mutations on the structure of HA and thus, provides a structural basis for the antigenic changes seen in human influenza viruses.
Keywords: antigenic; hemagglutinin; influenza; protein structure.
. 2023 Apr 19;15(4):1008.
doi: 10.3390/v15041008. Structural Consequences of Antigenic Variants of Human A/H3N2 Influenza Viruses
David Francis Burke[SUP] 1 [/SUP]
Affiliations
- PMID: 37112987
- DOI: 10.3390/v15041008
The genetic basis of antigenic drift of human A/H3N2 influenza virus is crucial to understanding the constraints of influenza evolution and determinants of vaccine escape. Amino acid changes at only seven positions near the receptor binding site of the surface hemagglutinin protein have been shown to be responsible for the major antigenic changes for over forty years. Experimental structures of HA are now available for the majority of the observed antigenic clusters of A/H3N2. An analysis of the HA structures of these viruses reveals the likely consequences of these mutations on the structure of HA and thus, provides a structural basis for the antigenic changes seen in human influenza viruses.
Keywords: antigenic; hemagglutinin; influenza; protein structure.