tetano
Editor, Senior Moderator
Viruses
. 2021 Jan 15;13(1):E112.
doi: 10.3390/v13010112.
Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women
Monica Cruz-Lemini[SUP] 1 [/SUP], Elena Ferriols Perez[SUP] 2 [/SUP], Maria Luisa de la Cruz Conty[SUP] 3 [/SUP], Africa Ca?o Aguilar[SUP] 4 [/SUP], Maria Bego?a Encinas Pardilla[SUP] 5 [/SUP], Pilar Prats Rodr?guez[SUP] 6 [/SUP], Marta Muner Hernando[SUP] 7 [/SUP], Laura Forcen Acebal[SUP] 8 [/SUP], Pilar Pintado Recarte[SUP] 9 [/SUP], Maria Del Carmen Medina Mallen[SUP] 1 [/SUP], Noelia Perez Perez[SUP] 10 [/SUP], Judit Canet Rodriguez[SUP] 11 [/SUP], Ana Villalba Yarza[SUP] 12 [/SUP], Olga Nieto Velasco[SUP] 13 [/SUP], Pablo Guillermo Del Barrio Fernandez[SUP] 14 [/SUP], Carmen Maria Orizales Lago[SUP] 15 [/SUP], Beatriz Marcos Puig[SUP] 16 [/SUP], Bego?a Mu?oz Abellana[SUP] 17 [/SUP], Laura Fuentes Ricoy[SUP] 18 [/SUP], Agueda Rodriguez Vicente[SUP] 19 [/SUP], Maria Jesus Janeiro Freire[SUP] 20 [/SUP], Macarena Alferez Alvarez-Mallo[SUP] 21 [/SUP], Cristina Casanova Pedraz[SUP] 22 [/SUP], Onofre Alomar Mateu[SUP] 23 [/SUP], Cristina Lesmes Heredia[SUP] 24 [/SUP], Juan Carlos Wizner de Alva[SUP] 25 [/SUP], Alma Posadas San Juan[SUP] 26 [/SUP], Montserrat Macia Badia[SUP] 27 [/SUP], Cristina Alvarez Colomo[SUP] 28 [/SUP], Antonio Sanchez Mu?oz[SUP] 29 [/SUP], Laia Pratcorona Alicart[SUP] 30 [/SUP], Ruben Alonso Saiz[SUP] 31 [/SUP], Monica Lopez Rodriguez[SUP] 32 [/SUP], Maria Carmen Barbancho Lopez[SUP] 33 [/SUP], Marta Ruth Meca Casbas[SUP] 34 [/SUP], Oscar Vaquerizo Ruiz[SUP] 35 [/SUP], Eva Moran Antolin[SUP] 36 [/SUP], Maria Jose Nu?ez Valera[SUP] 37 [/SUP], Camino Fernandez Fernandez[SUP] 38 [/SUP], Albert Tubau Navarra[SUP] 39 [/SUP], Alejandra Maria Cano Garcia[SUP] 40 [/SUP], Susana Soldevilla Perez[SUP] 41 [/SUP], Irene Gattaca Abasolo[SUP] 42 [/SUP], Jose Adanez Garcia[SUP] 43 [/SUP], Alberto Puertas Prieto[SUP] 44 [/SUP], Rosa Ostos Serna[SUP] 45 [/SUP], Maria Del Pilar Guadix Martin[SUP] 46 [/SUP], Monica Catalina Coello[SUP] 47 [/SUP], Silvia Espuelas Malon[SUP] 2 [/SUP], Jose Antonio Sainz Bueno[SUP] 48 [/SUP], Maria Reyes Granell Escobar[SUP] 49 [/SUP], Sara Cruz Melguizo[SUP] 5 [/SUP], Oscar Martinez Perez[SUP] 5 [/SUP], On Behalf Of The Spanish Obstetric Emergency Group
Affiliations
Abstract
Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.
Keywords: SARS-CoV-2; asymptomatic infection; coronavirus; delivery; maternal complications; perinatal outcomes; pregnancy.
. 2021 Jan 15;13(1):E112.
doi: 10.3390/v13010112.
Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women
Monica Cruz-Lemini[SUP] 1 [/SUP], Elena Ferriols Perez[SUP] 2 [/SUP], Maria Luisa de la Cruz Conty[SUP] 3 [/SUP], Africa Ca?o Aguilar[SUP] 4 [/SUP], Maria Bego?a Encinas Pardilla[SUP] 5 [/SUP], Pilar Prats Rodr?guez[SUP] 6 [/SUP], Marta Muner Hernando[SUP] 7 [/SUP], Laura Forcen Acebal[SUP] 8 [/SUP], Pilar Pintado Recarte[SUP] 9 [/SUP], Maria Del Carmen Medina Mallen[SUP] 1 [/SUP], Noelia Perez Perez[SUP] 10 [/SUP], Judit Canet Rodriguez[SUP] 11 [/SUP], Ana Villalba Yarza[SUP] 12 [/SUP], Olga Nieto Velasco[SUP] 13 [/SUP], Pablo Guillermo Del Barrio Fernandez[SUP] 14 [/SUP], Carmen Maria Orizales Lago[SUP] 15 [/SUP], Beatriz Marcos Puig[SUP] 16 [/SUP], Bego?a Mu?oz Abellana[SUP] 17 [/SUP], Laura Fuentes Ricoy[SUP] 18 [/SUP], Agueda Rodriguez Vicente[SUP] 19 [/SUP], Maria Jesus Janeiro Freire[SUP] 20 [/SUP], Macarena Alferez Alvarez-Mallo[SUP] 21 [/SUP], Cristina Casanova Pedraz[SUP] 22 [/SUP], Onofre Alomar Mateu[SUP] 23 [/SUP], Cristina Lesmes Heredia[SUP] 24 [/SUP], Juan Carlos Wizner de Alva[SUP] 25 [/SUP], Alma Posadas San Juan[SUP] 26 [/SUP], Montserrat Macia Badia[SUP] 27 [/SUP], Cristina Alvarez Colomo[SUP] 28 [/SUP], Antonio Sanchez Mu?oz[SUP] 29 [/SUP], Laia Pratcorona Alicart[SUP] 30 [/SUP], Ruben Alonso Saiz[SUP] 31 [/SUP], Monica Lopez Rodriguez[SUP] 32 [/SUP], Maria Carmen Barbancho Lopez[SUP] 33 [/SUP], Marta Ruth Meca Casbas[SUP] 34 [/SUP], Oscar Vaquerizo Ruiz[SUP] 35 [/SUP], Eva Moran Antolin[SUP] 36 [/SUP], Maria Jose Nu?ez Valera[SUP] 37 [/SUP], Camino Fernandez Fernandez[SUP] 38 [/SUP], Albert Tubau Navarra[SUP] 39 [/SUP], Alejandra Maria Cano Garcia[SUP] 40 [/SUP], Susana Soldevilla Perez[SUP] 41 [/SUP], Irene Gattaca Abasolo[SUP] 42 [/SUP], Jose Adanez Garcia[SUP] 43 [/SUP], Alberto Puertas Prieto[SUP] 44 [/SUP], Rosa Ostos Serna[SUP] 45 [/SUP], Maria Del Pilar Guadix Martin[SUP] 46 [/SUP], Monica Catalina Coello[SUP] 47 [/SUP], Silvia Espuelas Malon[SUP] 2 [/SUP], Jose Antonio Sainz Bueno[SUP] 48 [/SUP], Maria Reyes Granell Escobar[SUP] 49 [/SUP], Sara Cruz Melguizo[SUP] 5 [/SUP], Oscar Martinez Perez[SUP] 5 [/SUP], On Behalf Of The Spanish Obstetric Emergency Group
Affiliations
- PMID: 33467629
- DOI: 10.3390/v13010112
Abstract
Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.
Keywords: SARS-CoV-2; asymptomatic infection; coronavirus; delivery; maternal complications; perinatal outcomes; pregnancy.