Giuseppe
Emeritus
Virology. 2008 Aug 22. [Epub ahead of print]
Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631.
Sironi L, Williams JL, Moreno-Martin AM, Ramelli P, Stella A, Jianlin H, Weigend S, Lombardi G, Cordioli P, Mariani P. - Parco Tecnologico Padano - CERSA, via Einstein, Polo Universitario, 26900 Lodi, Italy.
Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection.
Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection.
Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles.
Birds in the other two lines were selected to be fixed for the A allele.
Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation.
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PMID: 18723201 [PubMed - as supplied by publisher
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Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631.
Sironi L, Williams JL, Moreno-Martin AM, Ramelli P, Stella A, Jianlin H, Weigend S, Lombardi G, Cordioli P, Mariani P. - Parco Tecnologico Padano - CERSA, via Einstein, Polo Universitario, 26900 Lodi, Italy.
Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection.
Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection.
Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles.
Birds in the other two lines were selected to be fixed for the A allele.
Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation.
-
PMID: 18723201 [PubMed - as supplied by publisher
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