tetano
Editor, Senior Moderator
Virol J
. 2023 Aug 28;20(1):193.
doi: 10.1186/s12985-023-02164-2. Immune response in influenza virus infection and modulation of immune injury by viral neuraminidase
Hongyu Jiang[SUP] 1 2 3 [/SUP], Zongde Zhang[SUP] 4 5 6 [/SUP]
Affiliations
Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection results in hypercytokinemia, which is responsible for mortality and morbidity. The influenza A virus surface glycoprotein neuraminidase (NA) plays a vital role in viral attachment, entry, and virion release from infected cells. NA acts as a sialidase, which cleaves sialic acids from cell surface proteins and carbohydrate side chains on nascent virions. Here, we review progress in understanding the role of NA in modulating host immune response to influenza virus infection. We also discuss recent exciting findings targeting NA protein to interrupt influenza-induced immune injury.
Keywords: CD83; Cytokine storm; Immune response; Influenza virus; Neuraminidase.
. 2023 Aug 28;20(1):193.
doi: 10.1186/s12985-023-02164-2. Immune response in influenza virus infection and modulation of immune injury by viral neuraminidase
Hongyu Jiang[SUP] 1 2 3 [/SUP], Zongde Zhang[SUP] 4 5 6 [/SUP]
Affiliations
- PMID: 37641134
- DOI: 10.1186/s12985-023-02164-2
Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection results in hypercytokinemia, which is responsible for mortality and morbidity. The influenza A virus surface glycoprotein neuraminidase (NA) plays a vital role in viral attachment, entry, and virion release from infected cells. NA acts as a sialidase, which cleaves sialic acids from cell surface proteins and carbohydrate side chains on nascent virions. Here, we review progress in understanding the role of NA in modulating host immune response to influenza virus infection. We also discuss recent exciting findings targeting NA protein to interrupt influenza-induced immune injury.
Keywords: CD83; Cytokine storm; Immune response; Influenza virus; Neuraminidase.