Mary Wilson
Well-known member
Published: February 16, 2023
https://doi.org/10.1371/journal.ppat.1011145
Jens B. Bosse, Wolfram Brune
Introduction
Cellular life is based on compartmentalization to sequester biochemical reactions. Two kinds of cellular compartments exist: membrane-enclosed and membrane-less compartments. The cytoplasm of eukaryotic cells harbors many membrane-enclosed compartments, such as the endoplasmic reticulum, lysosomes, and peroxisomes. At the same time, the cytoplasm and especially the nucleus are compartmentalized by membrane-less structures, such as nucleoli, promyelocytic leukemia nuclear bodies (PML-NBs), nuclear speckles, and others. Not surprisingly, viruses hijack both compartment types to facilitate their replication. While the genesis of membrane-enclosed compartments has been studied for decades, research only recently focused on the biophysical properties of membrane-less compartments. Here, we outline the basic principles of their formation and how viruses generate such compartments for replication and morphogenesis. As excellent in-depth reviews have recently been published [1–3], this article is meant to serve as a brief introduction to the field. ...
https://journals.plos.org/plospathog...l.ppat.1011145
https://doi.org/10.1371/journal.ppat.1011145
Jens B. Bosse, Wolfram Brune
Introduction
Cellular life is based on compartmentalization to sequester biochemical reactions. Two kinds of cellular compartments exist: membrane-enclosed and membrane-less compartments. The cytoplasm of eukaryotic cells harbors many membrane-enclosed compartments, such as the endoplasmic reticulum, lysosomes, and peroxisomes. At the same time, the cytoplasm and especially the nucleus are compartmentalized by membrane-less structures, such as nucleoli, promyelocytic leukemia nuclear bodies (PML-NBs), nuclear speckles, and others. Not surprisingly, viruses hijack both compartment types to facilitate their replication. While the genesis of membrane-enclosed compartments has been studied for decades, research only recently focused on the biophysical properties of membrane-less compartments. Here, we outline the basic principles of their formation and how viruses generate such compartments for replication and morphogenesis. As excellent in-depth reviews have recently been published [1–3], this article is meant to serve as a brief introduction to the field. ...
https://journals.plos.org/plospathog...l.ppat.1011145