tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2016 Mar 17. doi: 10.1111/irv.12390. [Epub ahead of print]
[h=1]Viable Influenza A Virus in Airborne Particles Expelled during Coughs vs. Exhalations.[/h] Lindsley WG[SUP]1[/SUP], Blachere FM[SUP]1[/SUP], Beezhold DH[SUP]1[/SUP], Thewlis RE[SUP]1[/SUP], Noorbakhsh B[SUP]1[/SUP], Othumpangat S[SUP]1[/SUP], Goldsmith WT[SUP]1[/SUP], McMillen CM[SUP]1[/SUP], Andrew ME[SUP]1[/SUP], Burrell CN[SUP]2[/SUP], Noti JD[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] In order to prepare for a possible influenza pandemic, a better understanding of the potential for airborne transmission of influenza from person to person is needed.
[h=4]OBJECTIVES:[/h] The objective of this study was to directly compare the generation of aerosol particles containing viable influenza virus during coughs and exhalations.
[h=4]METHODS:[/h] Sixty-one adult volunteer outpatients with influenza-like symptoms were asked to cough and exhale three times into a spirometer. Aerosol particles produced during coughing and exhalation were collected into liquid media using aerosol samplers. The samples were tested for the presence of viable influenza virus using a viral replication assay (VRA).
[h=4]RESULTS:[/h] Fifty-three test subjects tested positive for influenza A virus. Of these, 28 (53%) produced aerosol particles containing viable influenza A virus during coughing, and 22 (42%) produced aerosols with viable virus during exhalation. Thirteen subjects had both cough aerosol and exhalation aerosol samples that contained viable virus, 15 had positive cough aerosol samples but negative exhalation samples, and 9 had positive exhalation samples but negative cough samples.
[h=4]CONCLUSIONS:[/h] Viable influenza A virus was detected more often in cough aerosol particles than in exhalation aerosol particles, but the difference was not large. Since individuals breathe much more often than they cough, these results suggest that breathing may generate more airborne infectious material than coughing over time. However, both respiratory activities could be important in airborne influenza transmission. Our results are also consistent with the theory that much of the aerosol containing viable influenza originates deep in the lungs. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Aerosols; Air Microbiology; Airborne Transmission; Cough; Infectious Disease Transmission; Influenza
PMID: 26991074 [PubMed - as supplied by publisher] Free full text
[h=1]Viable Influenza A Virus in Airborne Particles Expelled during Coughs vs. Exhalations.[/h] Lindsley WG[SUP]1[/SUP], Blachere FM[SUP]1[/SUP], Beezhold DH[SUP]1[/SUP], Thewlis RE[SUP]1[/SUP], Noorbakhsh B[SUP]1[/SUP], Othumpangat S[SUP]1[/SUP], Goldsmith WT[SUP]1[/SUP], McMillen CM[SUP]1[/SUP], Andrew ME[SUP]1[/SUP], Burrell CN[SUP]2[/SUP], Noti JD[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] In order to prepare for a possible influenza pandemic, a better understanding of the potential for airborne transmission of influenza from person to person is needed.
[h=4]OBJECTIVES:[/h] The objective of this study was to directly compare the generation of aerosol particles containing viable influenza virus during coughs and exhalations.
[h=4]METHODS:[/h] Sixty-one adult volunteer outpatients with influenza-like symptoms were asked to cough and exhale three times into a spirometer. Aerosol particles produced during coughing and exhalation were collected into liquid media using aerosol samplers. The samples were tested for the presence of viable influenza virus using a viral replication assay (VRA).
[h=4]RESULTS:[/h] Fifty-three test subjects tested positive for influenza A virus. Of these, 28 (53%) produced aerosol particles containing viable influenza A virus during coughing, and 22 (42%) produced aerosols with viable virus during exhalation. Thirteen subjects had both cough aerosol and exhalation aerosol samples that contained viable virus, 15 had positive cough aerosol samples but negative exhalation samples, and 9 had positive exhalation samples but negative cough samples.
[h=4]CONCLUSIONS:[/h] Viable influenza A virus was detected more often in cough aerosol particles than in exhalation aerosol particles, but the difference was not large. Since individuals breathe much more often than they cough, these results suggest that breathing may generate more airborne infectious material than coughing over time. However, both respiratory activities could be important in airborne influenza transmission. Our results are also consistent with the theory that much of the aerosol containing viable influenza originates deep in the lungs. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Aerosols; Air Microbiology; Airborne Transmission; Cough; Infectious Disease Transmission; Influenza
PMID: 26991074 [PubMed - as supplied by publisher] Free full text