tetano
Editor, Senior Moderator
Vet Pathol
. 2022 Jan 18;3009858211067467.
doi: 10.1177/03009858211067467. Online ahead of print.
Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals
David S Rotstein[SUP] 1 [/SUP], Sarah Peloquin[SUP] 2 [/SUP], Kathleen Proia[SUP] 2 [/SUP], Ellen Hart[SUP] 1 [/SUP], Jeongha Lee[SUP] 3 [/SUP], Kristin K Vyhnal[SUP] 3 [/SUP], Emi Sasaki[SUP] 3 [/SUP], Gayathriy Balamayooran[SUP] 4 [/SUP], Javier Asin[SUP] 5 [/SUP], Teresa Southard[SUP] 6 [/SUP], Laura Rothfeldt[SUP] 7 [/SUP], Heather Venkat[SUP] 8 9 [/SUP], Peter Mundschenk[SUP] 10 [/SUP], Darby McDermott[SUP] 11 [/SUP], Beate Crossley[SUP] 5 [/SUP], Pamela Ferro[SUP] 4 [/SUP], Gabriel Gomez[SUP] 4 [/SUP], Eileen H Henderson[SUP] 5 [/SUP], Paul Narayan[SUP] 4 [/SUP], Daniel B Paulsen[SUP] 3 [/SUP], Steven Rekant[SUP] 12 [/SUP], Megan E Schroeder[SUP] 4 [/SUP], Rachel M Tell[SUP] 13 [/SUP], Mia Kim Torchetti[SUP] 13 [/SUP], Francisco A Uzal[SUP] 5 [/SUP], Ann Carpenter[SUP] 14 [/SUP], Ria Ghai[SUP] 14 [/SUP]
Affiliations
Abstract
Documented natural infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in exotic and companion animals following human exposures are uncommon. Those documented in animals are typically mild and self-limiting, and infected animals have only infrequently died or been euthanized. Through a coordinated One Health initiative, necropsies were conducted on 5 animals from different premises that were exposed to humans with laboratory-confirmed SARS-CoV-2 infection. The combination of epidemiologic evidence of exposure and confirmatory real-time reverse transcriptase-polymerase chain reaction testing confirmed infection in 3 cats and a tiger. A dog was a suspect case based on epidemiologic evidence of exposure but tested negative for SARS-CoV-2. Four animals had respiratory clinical signs that developed 2 to 12 days after exposure. The dog had bronchointerstitial pneumonia and the tiger had bronchopneumonia; both had syncytial-like cells with no detection of SARS-CoV-2. Individual findings in the 3 cats included metastatic mammary carcinoma, congenital renal disease, and myocardial disease. Based on the necropsy findings and a standardized algorithm, SARS-CoV-2 infection was not considered the cause of death in any of the cases. Continued surveillance and necropsy examination of animals with fatal outcomes will further our understanding of natural SARS-CoV-2 infection in animals and the potential role of the virus in development of lesions.
Keywords: COVID-19; bronchopneumonia; cats; dogs; respiratory; severe acute respiratory syndrome coronavirus 2; syncytial cell; tiger; viral; zoonosis.
. 2022 Jan 18;3009858211067467.
doi: 10.1177/03009858211067467. Online ahead of print.
Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals
David S Rotstein[SUP] 1 [/SUP], Sarah Peloquin[SUP] 2 [/SUP], Kathleen Proia[SUP] 2 [/SUP], Ellen Hart[SUP] 1 [/SUP], Jeongha Lee[SUP] 3 [/SUP], Kristin K Vyhnal[SUP] 3 [/SUP], Emi Sasaki[SUP] 3 [/SUP], Gayathriy Balamayooran[SUP] 4 [/SUP], Javier Asin[SUP] 5 [/SUP], Teresa Southard[SUP] 6 [/SUP], Laura Rothfeldt[SUP] 7 [/SUP], Heather Venkat[SUP] 8 9 [/SUP], Peter Mundschenk[SUP] 10 [/SUP], Darby McDermott[SUP] 11 [/SUP], Beate Crossley[SUP] 5 [/SUP], Pamela Ferro[SUP] 4 [/SUP], Gabriel Gomez[SUP] 4 [/SUP], Eileen H Henderson[SUP] 5 [/SUP], Paul Narayan[SUP] 4 [/SUP], Daniel B Paulsen[SUP] 3 [/SUP], Steven Rekant[SUP] 12 [/SUP], Megan E Schroeder[SUP] 4 [/SUP], Rachel M Tell[SUP] 13 [/SUP], Mia Kim Torchetti[SUP] 13 [/SUP], Francisco A Uzal[SUP] 5 [/SUP], Ann Carpenter[SUP] 14 [/SUP], Ria Ghai[SUP] 14 [/SUP]
Affiliations
- PMID: 35038930
- DOI: 10.1177/03009858211067467
Abstract
Documented natural infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in exotic and companion animals following human exposures are uncommon. Those documented in animals are typically mild and self-limiting, and infected animals have only infrequently died or been euthanized. Through a coordinated One Health initiative, necropsies were conducted on 5 animals from different premises that were exposed to humans with laboratory-confirmed SARS-CoV-2 infection. The combination of epidemiologic evidence of exposure and confirmatory real-time reverse transcriptase-polymerase chain reaction testing confirmed infection in 3 cats and a tiger. A dog was a suspect case based on epidemiologic evidence of exposure but tested negative for SARS-CoV-2. Four animals had respiratory clinical signs that developed 2 to 12 days after exposure. The dog had bronchointerstitial pneumonia and the tiger had bronchopneumonia; both had syncytial-like cells with no detection of SARS-CoV-2. Individual findings in the 3 cats included metastatic mammary carcinoma, congenital renal disease, and myocardial disease. Based on the necropsy findings and a standardized algorithm, SARS-CoV-2 infection was not considered the cause of death in any of the cases. Continued surveillance and necropsy examination of animals with fatal outcomes will further our understanding of natural SARS-CoV-2 infection in animals and the potential role of the virus in development of lesions.
Keywords: COVID-19; bronchopneumonia; cats; dogs; respiratory; severe acute respiratory syndrome coronavirus 2; syncytial cell; tiger; viral; zoonosis.
