tetano
Editor, Senior Moderator
J Infect Dis. (2011) doi: 10.1093/infdis/jir803 First published online: December 23, 2011
Validation of Self-swab for Virologic Confirmation of Influenza Virus Infections in a Community Setting
Dennis K. M. Ip1,
Martin Schutten3,
Vicky J. Fang1,
Rita O. P. Fung1,
Regina T. Dutkowski4,
Kwok-Hung Chan2,
Gabriel M. Leung1,
J. S. Malik Peiris1,2 and
Benjamin J. Cowling1
+ Author Affiliations
1School of Public Health
2Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region, China
3Erasmus Medical Centre, Rotterdam, the Netherlands
4Hoffmann-La Roche, Nutley, New Jersey
Correspondence: Dennis K. M. Ip, MBBS, MSc, MPhil, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Units 624-7, Core F, Cyberport 3, Pokfulam, Hong Kong (dkmip@hku.hk).
Abstract
Few studies have investigated the validity of self-collected nose and throat swabs for influenza confirmation in community settings. We followed outpatients with confirmed influenza with sequential measurement of viral loads and applied log-linear regression models to the viral shedding patterns. Among 176 outpatients with confirmed influenza, the detection of virus and quantitative viral loads obtained from self-swabs was consistent with statistical predictions based on earlier and later measurements, suggesting that self-collected nose and throat swabs can be a valid alternative for virologic confirmation of influenza A or B infection in a community setting.
http://jid.oxfordjournals.org/content/early/2011/12/23/infdis.jir803.abstract
Validation of Self-swab for Virologic Confirmation of Influenza Virus Infections in a Community Setting
Dennis K. M. Ip1,
Martin Schutten3,
Vicky J. Fang1,
Rita O. P. Fung1,
Regina T. Dutkowski4,
Kwok-Hung Chan2,
Gabriel M. Leung1,
J. S. Malik Peiris1,2 and
Benjamin J. Cowling1
+ Author Affiliations
1School of Public Health
2Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region, China
3Erasmus Medical Centre, Rotterdam, the Netherlands
4Hoffmann-La Roche, Nutley, New Jersey
Correspondence: Dennis K. M. Ip, MBBS, MSc, MPhil, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Units 624-7, Core F, Cyberport 3, Pokfulam, Hong Kong (dkmip@hku.hk).
Abstract
Few studies have investigated the validity of self-collected nose and throat swabs for influenza confirmation in community settings. We followed outpatients with confirmed influenza with sequential measurement of viral loads and applied log-linear regression models to the viral shedding patterns. Among 176 outpatients with confirmed influenza, the detection of virus and quantitative viral loads obtained from self-swabs was consistent with statistical predictions based on earlier and later measurements, suggesting that self-collected nose and throat swabs can be a valid alternative for virologic confirmation of influenza A or B infection in a community setting.
http://jid.oxfordjournals.org/content/early/2011/12/23/infdis.jir803.abstract