tetano
Editor, Senior Moderator
Vaccines (Basel)
. 2022 Jul 16;10(7):1136.
doi: 10.3390/vaccines10071136.
Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History
Veronica Santilli[SUP] 1 [/SUP], Emma Concetta Manno[SUP] 1 [/SUP], Carmela Giancotta[SUP] 1 [/SUP], Chiara Rossetti[SUP] 2 [/SUP], Nicola Cotugno[SUP] 1 2 [/SUP], Donato Amodio[SUP] 1 [/SUP], Gioacchino Andrea Rotulo[SUP] 3 4 [/SUP], Annalisa Deodati[SUP] 2 4 [/SUP], Roberto Bianchi[SUP] 5 [/SUP], Giulia Lucignani[SUP] 6 [/SUP], Daniela Longo[SUP] 6 [/SUP], Massimiliano Valeriani[SUP] 7 [/SUP], Paolo Palma[SUP] 1 2 [/SUP]
Affiliations
Abstract
The SARS-CoV-2 vaccine roll-out has been successful around the world. However, there are increasing concerns about adverse events. We report two pediatric cases of Multisystem-Inflammatory-Syndrome (MIS-C) with neurological involvement that occurred after SARS-CoV-2 vaccination and unknown recent SARS-CoV-2 infection. Brain magnetic resonance revealed mild-encephalopathy with reversible-splenial-lesion in both cases and complete resolution within 4 weeks. In conclusion, this report aims to describe rare emerging clinical entities that can help pediatricians to make an early diagnosis and to provide appropriate treatment. Multisystem-Inflammatory-Syndromes following COVID-19 vaccination remain rare events. When a history of a recent contact with SARS-CoV-2 is present, a careful evaluation by the clinicians in charge of immunization activities is suggested prior to proceeding with the vaccination.
Keywords: COVID-19 vaccination; mild encephalitis/encephalopathy with reversible splenial lesion (MERS); multisystem inflammatory syndrome following SARS-CoV-2 vaccination (MIS-V); multisystem inflammatory syndrome in children (MIS-C); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2022 Jul 16;10(7):1136.
doi: 10.3390/vaccines10071136.
Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History
Veronica Santilli[SUP] 1 [/SUP], Emma Concetta Manno[SUP] 1 [/SUP], Carmela Giancotta[SUP] 1 [/SUP], Chiara Rossetti[SUP] 2 [/SUP], Nicola Cotugno[SUP] 1 2 [/SUP], Donato Amodio[SUP] 1 [/SUP], Gioacchino Andrea Rotulo[SUP] 3 4 [/SUP], Annalisa Deodati[SUP] 2 4 [/SUP], Roberto Bianchi[SUP] 5 [/SUP], Giulia Lucignani[SUP] 6 [/SUP], Daniela Longo[SUP] 6 [/SUP], Massimiliano Valeriani[SUP] 7 [/SUP], Paolo Palma[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35891300
- DOI: 10.3390/vaccines10071136
Abstract
The SARS-CoV-2 vaccine roll-out has been successful around the world. However, there are increasing concerns about adverse events. We report two pediatric cases of Multisystem-Inflammatory-Syndrome (MIS-C) with neurological involvement that occurred after SARS-CoV-2 vaccination and unknown recent SARS-CoV-2 infection. Brain magnetic resonance revealed mild-encephalopathy with reversible-splenial-lesion in both cases and complete resolution within 4 weeks. In conclusion, this report aims to describe rare emerging clinical entities that can help pediatricians to make an early diagnosis and to provide appropriate treatment. Multisystem-Inflammatory-Syndromes following COVID-19 vaccination remain rare events. When a history of a recent contact with SARS-CoV-2 is present, a careful evaluation by the clinicians in charge of immunization activities is suggested prior to proceeding with the vaccination.
Keywords: COVID-19 vaccination; mild encephalitis/encephalopathy with reversible splenial lesion (MERS); multisystem inflammatory syndrome following SARS-CoV-2 vaccination (MIS-V); multisystem inflammatory syndrome in children (MIS-C); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).