tetano
Editor, Senior Moderator
Vaccines (Basel)
. 2021 Oct 29;9(11):1251.
doi: 10.3390/vaccines9111251.
Kikuchi-Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature
Hui Min Tan[SUP] 1 [/SUP], Susan Swee-Shan Hue[SUP] 1 [/SUP], Aileen Wee[SUP] 1 [/SUP], Kay Choong See[SUP] 2 [/SUP]
Affiliations
Abstract
With the rapid development of various coronavirus disease 2019 (COVID-19) vaccines in a bid to counter and contain the COVID-19 pandemic, unusual and uncommon side effects of COVID-19 vaccination have been increasingly reported in the literature. Ipsilateral lymphadenopathy is a fairly common side effect of vaccination of any kind, with its etiology most commonly related to reactive lymphadenopathy. However, Kikuchi-Fujimoto Disease (KFD) or necrotizing histiocytic lymphadenitis is rarely observed post-vaccination, with only one other case of KFD post COVID-19 vaccination reported to date. We report two more cases of KFD post COVID-19 vaccination in the Asian population, highlighting the clinical course and salient clinical, radiological and histologic findings. In addition, we provide a literature review of the existing cases of lymphadenopathy post COVID-19 vaccination with cytologic and/or histologic correlation.
Keywords: COVID-19; COVID-19 vaccine; Kikuchi–Fujimoto disease; lymphadenopathy; necrotizing histiocytic lymphadenitis.
. 2021 Oct 29;9(11):1251.
doi: 10.3390/vaccines9111251.
Kikuchi-Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature
Hui Min Tan[SUP] 1 [/SUP], Susan Swee-Shan Hue[SUP] 1 [/SUP], Aileen Wee[SUP] 1 [/SUP], Kay Choong See[SUP] 2 [/SUP]
Affiliations
- PMID: 34835182
- DOI: 10.3390/vaccines9111251
Abstract
With the rapid development of various coronavirus disease 2019 (COVID-19) vaccines in a bid to counter and contain the COVID-19 pandemic, unusual and uncommon side effects of COVID-19 vaccination have been increasingly reported in the literature. Ipsilateral lymphadenopathy is a fairly common side effect of vaccination of any kind, with its etiology most commonly related to reactive lymphadenopathy. However, Kikuchi-Fujimoto Disease (KFD) or necrotizing histiocytic lymphadenitis is rarely observed post-vaccination, with only one other case of KFD post COVID-19 vaccination reported to date. We report two more cases of KFD post COVID-19 vaccination in the Asian population, highlighting the clinical course and salient clinical, radiological and histologic findings. In addition, we provide a literature review of the existing cases of lymphadenopathy post COVID-19 vaccination with cytologic and/or histologic correlation.
Keywords: COVID-19; COVID-19 vaccine; Kikuchi–Fujimoto disease; lymphadenopathy; necrotizing histiocytic lymphadenitis.