tetano
Editor, Senior Moderator
Vaccines (Basel)
. 2020 Aug 20;8(3):E459.
doi: 10.3390/vaccines8030459.
Impact of Pre-Existing Immunity on Live Attenuated Influenza Vaccine-Induced Cross-Protective Immunity
Sreeja Roy[SUP] 1 [/SUP], Clare M Williams[SUP] 1 [/SUP], Julian Pardo[SUP] 2 [/SUP], Danushka K Wijesundara[SUP] 3 [/SUP], Yoichi Furuya[SUP] 1 [/SUP]
Affiliations
Abstract
The efficacy of the intranasally (i.n.) delivered live attenuated influenza vaccine (LAIV) is variable and, in some seasons, suboptimal. In this study, we report that LAIV exhibits cross-protective efficacy in mice, potentially associated with cellular immunity as opposed to antigen-specific antibody responses. However, pre-exposure to the intramuscularly (i.m.) delivered inactivated influenza vaccine (IIV) severely impaired LAIV-induced cross-protection against heterologous challenge, potentially by inhibiting replication of LAIV. Our findings suggest that pre-existing immunity afforded by IIV suppresses cross-protective T cell immunogenicity of LAIV.
Keywords: inactivated influenza vaccine; influenza; live attenuated influenza vaccine; pre-existing immunity.
. 2020 Aug 20;8(3):E459.
doi: 10.3390/vaccines8030459.
Impact of Pre-Existing Immunity on Live Attenuated Influenza Vaccine-Induced Cross-Protective Immunity
Sreeja Roy[SUP] 1 [/SUP], Clare M Williams[SUP] 1 [/SUP], Julian Pardo[SUP] 2 [/SUP], Danushka K Wijesundara[SUP] 3 [/SUP], Yoichi Furuya[SUP] 1 [/SUP]
Affiliations
- PMID: 32825218
- DOI: 10.3390/vaccines8030459
Abstract
The efficacy of the intranasally (i.n.) delivered live attenuated influenza vaccine (LAIV) is variable and, in some seasons, suboptimal. In this study, we report that LAIV exhibits cross-protective efficacy in mice, potentially associated with cellular immunity as opposed to antigen-specific antibody responses. However, pre-exposure to the intramuscularly (i.m.) delivered inactivated influenza vaccine (IIV) severely impaired LAIV-induced cross-protection against heterologous challenge, potentially by inhibiting replication of LAIV. Our findings suggest that pre-existing immunity afforded by IIV suppresses cross-protective T cell immunogenicity of LAIV.
Keywords: inactivated influenza vaccine; influenza; live attenuated influenza vaccine; pre-existing immunity.