tetano
Editor, Senior Moderator
Vaccines (Basel)
. 2022 May 10;10(5):749.
doi: 10.3390/vaccines10050749.
COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study
Cristiane de Freitas Paganoti[SUP] 1 [/SUP], Rafaela Alkmin da Costa[SUP] 1 [/SUP], Aris T Papageorghiou[SUP] 2 [/SUP], Fabrício da Silva Costa[SUP] 3 [/SUP], Silvana Maria Quintana[SUP] 4 [/SUP], Luciana Graziela de Godoi[SUP] 5 [/SUP], Nátaly Adriana Jiménez Monroy[SUP] 5 [/SUP], Agatha Sacramento Rodrigues[SUP] 5 [/SUP], Rossana Pulcineli Vieira Francisco[SUP] 6 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has had deleterious effects among the obstetric population. Pregnant and postpartum women constitute a high-risk group for severe COVID-19. Vaccination reduces the risk of infection, but it is not known whether women who become infected despite vaccination have a milder course of disease than those who had not been vaccinated. This retrospective cohort study evaluated whether vaccination reduces the severity of COVID-19 infection, as measured by severe maternal morbidity and mortality among hospitalized pregnant and postpartum individuals. A total of 2284 pregnant and postpartum women hospitalized with severe COVID-19 were included. Those who did and who did not receive COVID-19 vaccination were compared. The rates of intensive care unit admission, intubation, and mortality were significantly lower among subjects in the vaccinated group (p < 0.001, p < 0.001 and p < 0.001, respectively). The numbers of patients who needed to be vaccinated to avoid one case of intensive care unit admission, intubation, or death due to COVID-19 were 7, 7, and 9, respectively. The COVID-19 vaccine offers protective effects against intensive care unit admission, intubation, and death in hospitalized pregnant and postpartum women with severe SARS-CoV-2-induced SARS.
Keywords: COVID-19 vaccines; intensive care unit; intubation; maternal mortality; pregnancy; severe acute respiratory syndrome.
. 2022 May 10;10(5):749.
doi: 10.3390/vaccines10050749.
COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study
Cristiane de Freitas Paganoti[SUP] 1 [/SUP], Rafaela Alkmin da Costa[SUP] 1 [/SUP], Aris T Papageorghiou[SUP] 2 [/SUP], Fabrício da Silva Costa[SUP] 3 [/SUP], Silvana Maria Quintana[SUP] 4 [/SUP], Luciana Graziela de Godoi[SUP] 5 [/SUP], Nátaly Adriana Jiménez Monroy[SUP] 5 [/SUP], Agatha Sacramento Rodrigues[SUP] 5 [/SUP], Rossana Pulcineli Vieira Francisco[SUP] 6 [/SUP]
Affiliations
- PMID: 35632505
- DOI: 10.3390/vaccines10050749
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has had deleterious effects among the obstetric population. Pregnant and postpartum women constitute a high-risk group for severe COVID-19. Vaccination reduces the risk of infection, but it is not known whether women who become infected despite vaccination have a milder course of disease than those who had not been vaccinated. This retrospective cohort study evaluated whether vaccination reduces the severity of COVID-19 infection, as measured by severe maternal morbidity and mortality among hospitalized pregnant and postpartum individuals. A total of 2284 pregnant and postpartum women hospitalized with severe COVID-19 were included. Those who did and who did not receive COVID-19 vaccination were compared. The rates of intensive care unit admission, intubation, and mortality were significantly lower among subjects in the vaccinated group (p < 0.001, p < 0.001 and p < 0.001, respectively). The numbers of patients who needed to be vaccinated to avoid one case of intensive care unit admission, intubation, or death due to COVID-19 were 7, 7, and 9, respectively. The COVID-19 vaccine offers protective effects against intensive care unit admission, intubation, and death in hospitalized pregnant and postpartum women with severe SARS-CoV-2-induced SARS.
Keywords: COVID-19 vaccines; intensive care unit; intubation; maternal mortality; pregnancy; severe acute respiratory syndrome.