tetano
Editor, Senior Moderator
Vaccine
. 2021 Jan 15;S0264-410X(21)00001-3.
doi: 10.1016/j.vaccine.2021.01.001. Online ahead of print.
The humoral immune response to high-dose influenza vaccine in persons with monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL)
Jennifer A Whitaker[SUP] 1 [/SUP], Sameer A Parikh[SUP] 2 [/SUP], Tait D Shanafelt[SUP] 3 [/SUP], Neil E Kay[SUP] 2 [/SUP], Richard B Kennedy[SUP] 4 [/SUP], Diane E Grill[SUP] 5 [/SUP], Krista M Goergen[SUP] 5 [/SUP], Timothy G Call[SUP] 2 [/SUP], Saad S Kendarian[SUP] 2 [/SUP], Wei Ding[SUP] 2 [/SUP], Gregory A Poland[SUP] 4 [/SUP]
Affiliations
Abstract
Background: Limited data are available regarding the immunogenicity of high-dose influenza vaccine among persons with chronic lymphocytic leukemia (CLL) and monoclonal B cell lymphocytosis (MBL).
Methods: A prospective pilot study of humoral immune responses to 2013-2014 and 2014-2015 high-dose trivalent influenza vaccine (HD IIV; Fluzone? High-Dose; Sanofi Pasteur) was conducted among individuals with MBL and previously untreated CLL. Serum hemagglutination inhibition (HAI) antibody titers were measured at baseline and Day 28 after vaccination; seroprotection and seroconversion rates were determined. Memory B cell responses were assessed by B-cell enzyme-linked immune absorbent spotassays.
Results: Thirty subjects (17 CLL and 13 MBL) were included. Median age was 69.5 years. Day 28 seroprotection rates for the cohort were 19/30 (63.3%) for A/H1N1; 21/23 (91.3%) for A/H3N2; and 13/30 (43.3%) for influenza B. Those with MBL achieved higher day 28 HAI geometric mean titers (54.1 [4.9, 600.1] vs. 12.1 [1.3, 110.1]; p = 0.01) and higher Day 28 seroprotection rates (76.9% vs. 17.6%; p = 0.002) against the influenza B-vaccine strain virus than those with CLL.
Conclusions: Immunogenicity of the HD IIV3 in patients with CLL and MBL is lower than reported in healthy adults. Immunogenicity to influenza B was greater in those with MBL than CLL.
Keywords: B-cell; Chronic; Influenza; Influenza vaccines; Leukemia; Lymphocytic; Monoclonal B cell lymphocytosis.
. 2021 Jan 15;S0264-410X(21)00001-3.
doi: 10.1016/j.vaccine.2021.01.001. Online ahead of print.
The humoral immune response to high-dose influenza vaccine in persons with monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL)
Jennifer A Whitaker[SUP] 1 [/SUP], Sameer A Parikh[SUP] 2 [/SUP], Tait D Shanafelt[SUP] 3 [/SUP], Neil E Kay[SUP] 2 [/SUP], Richard B Kennedy[SUP] 4 [/SUP], Diane E Grill[SUP] 5 [/SUP], Krista M Goergen[SUP] 5 [/SUP], Timothy G Call[SUP] 2 [/SUP], Saad S Kendarian[SUP] 2 [/SUP], Wei Ding[SUP] 2 [/SUP], Gregory A Poland[SUP] 4 [/SUP]
Affiliations
- PMID: 33461835
- DOI: 10.1016/j.vaccine.2021.01.001
Abstract
Background: Limited data are available regarding the immunogenicity of high-dose influenza vaccine among persons with chronic lymphocytic leukemia (CLL) and monoclonal B cell lymphocytosis (MBL).
Methods: A prospective pilot study of humoral immune responses to 2013-2014 and 2014-2015 high-dose trivalent influenza vaccine (HD IIV; Fluzone? High-Dose; Sanofi Pasteur) was conducted among individuals with MBL and previously untreated CLL. Serum hemagglutination inhibition (HAI) antibody titers were measured at baseline and Day 28 after vaccination; seroprotection and seroconversion rates were determined. Memory B cell responses were assessed by B-cell enzyme-linked immune absorbent spotassays.
Results: Thirty subjects (17 CLL and 13 MBL) were included. Median age was 69.5 years. Day 28 seroprotection rates for the cohort were 19/30 (63.3%) for A/H1N1; 21/23 (91.3%) for A/H3N2; and 13/30 (43.3%) for influenza B. Those with MBL achieved higher day 28 HAI geometric mean titers (54.1 [4.9, 600.1] vs. 12.1 [1.3, 110.1]; p = 0.01) and higher Day 28 seroprotection rates (76.9% vs. 17.6%; p = 0.002) against the influenza B-vaccine strain virus than those with CLL.
Conclusions: Immunogenicity of the HD IIV3 in patients with CLL and MBL is lower than reported in healthy adults. Immunogenicity to influenza B was greater in those with MBL than CLL.
Keywords: B-cell; Chronic; Influenza; Influenza vaccines; Leukemia; Lymphocytic; Monoclonal B cell lymphocytosis.