Vaccine. Swine influenza matrix 2 (M2) protein contributes to protection against infection with different H1 swine influenza virus (SIV) isolates.

[Giuseppe]

Vaccine. 2009 Oct 15. [Epub ahead of print]

Swine influenza matrix 2 (M2) protein contributes to protection against infection with different H1 swine influenza virus (SIV) isolates.

Kitikoon P, Vincent AL, Janke BH, Erickson B, Strait EL, Yu S, Gramer MR, Thacker EL. - College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

A swine influenza virus (SIV) vaccine-challenge pig model was used to study the potential of a conserved matrix 2 (M2) protein vaccine alone or in combination with an inactivated H1N1-vaccine to protect against H1N1 and H1N2 viruses. The H1N1-vaccine and heterologous H1N2-challenge virus model has previously been shown to prolong fever and increase SIV-associated pneumonic lesions. The M2 vaccine in combination with the H1N1-vaccine reduced the H1N2 induced fever but not virus shedding. The M2 vaccine alone reduced respiratory signs and pneumonic lesions to levels similar to the negative control pigs following H1N2 infection. This study found that the M2 protein has potential as a vaccine for SIV-associated disease prevention. However, development of an immune response towards the major envelope HA protein was required to reduce SIV shedding.

PMID: 19837089 [PubMed - as supplied by publisher]

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[gsgs]

Re: Vaccine. Swine influenza matrix 2 (M2) protein contributes to protection against infection with different H1 swine influenza virus (SIV) isolates.

is this life(full) attenuated virus vaccine ?
normal (split) vaccine only has HA (and maybe a little NA)
but is that HA+NA bound in PR34-virus ? I don't know (forgot)

also:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725899/?tool=pubmed
Emerg Infect Dis. 2007 March; 13(3): 426–435.
doi: 10.3201/eid1303.061125.PMCID: PMC2725899
Copyright notice
Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1
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Changes in influenza viruses require regular reformulation of strain-specific influenza vaccines. Vaccines based on conserved antigens provide broader protection. Influenza matrix protein 2 (M2) is highly conserved across influenza A subtypes. To evaluate its efficacy as a vaccine candidate, we vaccinated mice with M2 peptide of a widely shared consensus sequence. This vaccination induced antibodies that cross-reacted with divergent M2 peptide from an H5N1 subtype. A DNA vaccine expressing full-length consensus-sequence M2 (M2-DNA) induced M2-specific antibody responses and protected against challenge with lethal influenza. Mice primed with M2-DNA and then boosted with recombinant adenovirus expressing M2 (M2-Ad) had enhanced antibody responses that cross-reacted with human and avian M2 sequences and induced T-cell responses. This M2 prime-boost vaccination conferred broad protection against challenge with lethal influenza A, including an H5N1 strain. Vaccination with M2, with key sequences represented, may provide broad protection against influenza A.

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All of the material available from the PMC site is provided by the respective publishers or authors. Almost all of it is protected by U.S. and/or foreign copyright laws, even though PMC provides free access to it. (See Public Domain Material below, for one exception.)
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ahh, pubmed has copyright isues now.
Waiting for another pubmed-like organization to develope
and going online, maybe non-USA

I see several competing areas of research developing : free access and secret.
The secret guys also try to hide it's secret ...
But finally there will hopefully be some search engine which lets me
search for public domain stuff only.
Only once it's in PD, it's really accepted as result. Non-PD results need to be
repeated by PD-authors

 

[AlaskaDenise]

Re: Vaccine. Swine influenza matrix 2 (M2) protein contributes to protection against infection with different H1 swine influenza virus (SIV) isolates.

From #1 (15 Oct 09):

However, development of an immune response towards the major envelope HA protein was required to reduce SIV shedding.

Since the earlier study (in #2) was using mice, I wonder if this mention of needing an immune reponse against HA is a difference between hosts (mice vs swine) or inherent in all influenza A vaccination situations.

.