tetano
Editor, Senior Moderator
Vaccine
Volume 30, Issue 51, 7 December 2012, Pages 7353?7358
Fourth ESWI Influenza Conference
Cover image
Nuclear import of the influenza A virus transcriptional machinery
E.C. Hutchinson,
E. FodorCorresponding author contact information, E-mail the corresponding author
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
http://dx.doi.org/10.1016/j.vaccine.2012.04.085
Abstract
Unusually for an RNA virus, influenza A viruses transcribe and replicate their genomes in the nuclei of infected cells. As a result the viral ribonucleoprotein complexes (RNPs), and their newly synthesised protein subunits, must interact with the host nuclear import machinery. In this review we discuss how the virus exploits nuclear import pathways to allow regulated and chaperoned assembly of RNPs in the nucleus, and describe how the import machinery itself can be a determinant of host tropism.
Highlights
► The transcriptional machinery of influenza viruses (RNPs) is transported into the nucleus. ► The virus recruits importins for transport and to chaperone and regulate RNP assembly. ► Interactions with importins can be host-dependent and act as barriers to cross-species transmission.
http://www.sciencedirect.com/science/article/pii/S0264410X12006317
Volume 30, Issue 51, 7 December 2012, Pages 7353?7358
Fourth ESWI Influenza Conference
Cover image
Nuclear import of the influenza A virus transcriptional machinery
E.C. Hutchinson,
E. FodorCorresponding author contact information, E-mail the corresponding author
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
http://dx.doi.org/10.1016/j.vaccine.2012.04.085
Abstract
Unusually for an RNA virus, influenza A viruses transcribe and replicate their genomes in the nuclei of infected cells. As a result the viral ribonucleoprotein complexes (RNPs), and their newly synthesised protein subunits, must interact with the host nuclear import machinery. In this review we discuss how the virus exploits nuclear import pathways to allow regulated and chaperoned assembly of RNPs in the nucleus, and describe how the import machinery itself can be a determinant of host tropism.
Highlights
► The transcriptional machinery of influenza viruses (RNPs) is transported into the nucleus. ► The virus recruits importins for transport and to chaperone and regulate RNP assembly. ► Interactions with importins can be host-dependent and act as barriers to cross-species transmission.
http://www.sciencedirect.com/science/article/pii/S0264410X12006317