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Vaccine . Influenza vaccine uptake among youth with sickle cell disease who are seen in clinic before and after the COVID-19 pandemic

tetano

Editor, Senior Moderator
Vaccine


. 2024 Aug 9;42(22):126212.
doi: 10.1016/j.vaccine.2024.126212. Online ahead of print. Influenza vaccine uptake among youth with sickle cell disease who are seen in clinic before and after the COVID-19 pandemic

Joseph Walden[SUP] 1 [/SUP], Joseph R Stanek[SUP] 2 [/SUP], Jennifer Young[SUP] 3 [/SUP], Megan M Griffith[SUP] 4 [/SUP], Leena Nahata[SUP] 5 [/SUP], Susan E Creary[SUP] 6 [/SUP]



Affiliations
Abstract

Influenza vaccination is critical for children with sickle cell disease (SCD) due to risks of severe influenza infections. Despite declining influenza vaccination among children since the COVID-19 pandemic, less is known about influenza vaccine coverage among youth with SCD during this same period. We compared influenza vaccine uptake among youth with SCD seen by a SCD provider in clinic during the 2019-2020 and 2022-2023 influenza seasons and described infection characteristics. Overall, 85% (n = 220) of children received their influenza vaccine during 2019-2020 compared to 75% (n = 245) in 2022-2023 (p = 0.059). Participants seen during both seasons were more likely to shift from vaccinated in 2019-2020 to unvaccinated in 2022-2023 than vice versa (McNemar's OR = 3.0; p = 0.008). Among 66 documented infections, 25.8% resulted in hospitalization. We found high influenza vaccine uptake but those seen during both seasons were more likely to become unvaccinated. More research is needed to understand influenza vaccine decision-making in this population.

Keywords: Influenza; Sickle cell disease; Vaccination; Vaccine coverage; Youth.

 
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