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Vaccine
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doi:10.1016/j.vaccine.2011.09.037
Vaccine effectiveness for laboratory-confirmed influenza in children 6?59 months of age, 2005?2007
Mary Allen Staata, 1, Corresponding Author Contact Information, E-mail The Corresponding Author, Marie R. Griffinb, c, 1, Stephanie Donauera, 1, Kathryn M. Edwardsd, 1, Peter G. Szilagyie, 1, Geoffrey A. Weinberge, 1, Caroline B. Halle, 1, Mila M. Prillf, 1, Sandra S. Chavesg, 1, Carolyn B. Bridgesg, 1, Katherine A. Poehlingh, 1, Gerry Fairbrothera, 1
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a Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
b Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States
c Preventive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States
d Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States
e Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States
f Division of Viral Diseases, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA, United States
g Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA, United States
h Departments of Pediatrics and Epidemiology and Prevention, Wake Forest University Medical Center, Winston-Salem, NC, United States
Received 12 May 2011; revised 7 September 2011; Accepted 10 September 2011. Available online 21 September 2011.
Abstract
To estimate the effectiveness of influenza vaccine against medical care visits for laboratory-confirmed influenza in young children we conducted a matched case?control study in children with acute respiratory illness or fever from 2005?2007. Influenza vaccine effectiveness (VE) was calculated using cases with laboratory-confirmed influenza and controls who tested negative for influenza. The effectiveness of influenza vaccine in fully vaccinated children 6?59 months of age was 56% (95% CI: 25%?74%); a significant VE was not found for partial vaccination.
http://www.sciencedirect.com/science/article/pii/S0264410X11014435
In Press, Uncorrected Proof - Note to users
doi:10.1016/j.vaccine.2011.09.037
Vaccine effectiveness for laboratory-confirmed influenza in children 6?59 months of age, 2005?2007
Mary Allen Staata, 1, Corresponding Author Contact Information, E-mail The Corresponding Author, Marie R. Griffinb, c, 1, Stephanie Donauera, 1, Kathryn M. Edwardsd, 1, Peter G. Szilagyie, 1, Geoffrey A. Weinberge, 1, Caroline B. Halle, 1, Mila M. Prillf, 1, Sandra S. Chavesg, 1, Carolyn B. Bridgesg, 1, Katherine A. Poehlingh, 1, Gerry Fairbrothera, 1
Purchase
a Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
b Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States
c Preventive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States
d Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States
e Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States
f Division of Viral Diseases, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA, United States
g Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA, United States
h Departments of Pediatrics and Epidemiology and Prevention, Wake Forest University Medical Center, Winston-Salem, NC, United States
Received 12 May 2011; revised 7 September 2011; Accepted 10 September 2011. Available online 21 September 2011.
Abstract
To estimate the effectiveness of influenza vaccine against medical care visits for laboratory-confirmed influenza in young children we conducted a matched case?control study in children with acute respiratory illness or fever from 2005?2007. Influenza vaccine effectiveness (VE) was calculated using cases with laboratory-confirmed influenza and controls who tested negative for influenza. The effectiveness of influenza vaccine in fully vaccinated children 6?59 months of age was 56% (95% CI: 25%?74%); a significant VE was not found for partial vaccination.
http://www.sciencedirect.com/science/article/pii/S0264410X11014435