tetano
Editor, Senior Moderator
Vaccine
. 2022 Aug 22;S0264-410X(22)01027-1.
doi: 10.1016/j.vaccine.2022.08.035. Online ahead of print.
Antibody titers among healthcare workers for coronavirus disease 2019 at 6 months after BNT162b2 vaccination
Kazuyoshi Kurashima[SUP] 1 [/SUP], Tsuyoshi Numano[SUP] 2 [/SUP], Atsuki Yoshino[SUP] 3 [/SUP], Akiko Osawa[SUP] 4 [/SUP], Yotaro Takaku[SUP] 5 [/SUP], Naho Kagiyama[SUP] 6 [/SUP], Tsutomu Yanagisawa[SUP] 7 [/SUP]
Affiliations
Abstract
Background: Antibody levels decrease substantially at 6 months after the BNT162b2 vaccine. The factors influencing titer of antibodies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) among healthcare workers for coronavirus disease 2019 (COVID-19) is unclear.
Methods: We conducted a 6-month longitudinal prospective study in Japanese healthcare workers in a tertiary care hospital for COVID-19. Participants in the study were tested for the presence of anti-spike protein (SP) IgG antibodies before and at 1 and 6 months after the last vaccination dose.
Results: Among 1076 healthcare workers, 794 received the vaccine, and 469 entered the study. Five were infected with SARS-CoV-2 (none among COVID-19 section workers) by the end of the study and 451 participants were finally analyzed (mean age, 42.5 years; 27.3 % male; 18.8 % COVID-19 section workers). Median SP IgG index values were 0.0, 44.4, and 5.5 before and at 1 and 6 months after the last dose, respectively. Regression analysis revealed a negative correlation of SP IgG antibody levels with age (P < 0.0001), and higher levels in COVID-19 section workers (P = 0.0185) and in females (P = 0.0201).
Conclusion: In healthcare workers at a COVID-19 hospital, IgG antibody titer was substantially lower at 6 months after receipt of the last dose of the BNT162b2 vaccine compared with that 1 month after the last dose, but was better preserved among younger participants, COVID-19 section workers and females.
Keywords: Antibody titre; Coronavirus disease-2019; Healthcare workers; Side effects; Vaccination.
. 2022 Aug 22;S0264-410X(22)01027-1.
doi: 10.1016/j.vaccine.2022.08.035. Online ahead of print.
Antibody titers among healthcare workers for coronavirus disease 2019 at 6 months after BNT162b2 vaccination
Kazuyoshi Kurashima[SUP] 1 [/SUP], Tsuyoshi Numano[SUP] 2 [/SUP], Atsuki Yoshino[SUP] 3 [/SUP], Akiko Osawa[SUP] 4 [/SUP], Yotaro Takaku[SUP] 5 [/SUP], Naho Kagiyama[SUP] 6 [/SUP], Tsutomu Yanagisawa[SUP] 7 [/SUP]
Affiliations
- PMID: 36030124
- DOI: 10.1016/j.vaccine.2022.08.035
Abstract
Background: Antibody levels decrease substantially at 6 months after the BNT162b2 vaccine. The factors influencing titer of antibodies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) among healthcare workers for coronavirus disease 2019 (COVID-19) is unclear.
Methods: We conducted a 6-month longitudinal prospective study in Japanese healthcare workers in a tertiary care hospital for COVID-19. Participants in the study were tested for the presence of anti-spike protein (SP) IgG antibodies before and at 1 and 6 months after the last vaccination dose.
Results: Among 1076 healthcare workers, 794 received the vaccine, and 469 entered the study. Five were infected with SARS-CoV-2 (none among COVID-19 section workers) by the end of the study and 451 participants were finally analyzed (mean age, 42.5 years; 27.3 % male; 18.8 % COVID-19 section workers). Median SP IgG index values were 0.0, 44.4, and 5.5 before and at 1 and 6 months after the last dose, respectively. Regression analysis revealed a negative correlation of SP IgG antibody levels with age (P < 0.0001), and higher levels in COVID-19 section workers (P = 0.0185) and in females (P = 0.0201).
Conclusion: In healthcare workers at a COVID-19 hospital, IgG antibody titer was substantially lower at 6 months after receipt of the last dose of the BNT162b2 vaccine compared with that 1 month after the last dose, but was better preserved among younger participants, COVID-19 section workers and females.
Keywords: Antibody titre; Coronavirus disease-2019; Healthcare workers; Side effects; Vaccination.