tetano
Editor, Senior Moderator
Vaccine
Volume 30, Issue 51, 7 December 2012, Pages 7407?7410
Fourth ESWI Influenza Conference
Cover image
Annual influenza vaccination affects the development of heterosubtypic immunity
Rogier Bodewesa, Corresponding author contact information, E-mail the corresponding author,
Pieter L.A. Fraaija, b,
Joost H.C.M. Kreijtza,
Martina M. Geelhoed-Mierasa,
Ron A.M. Fouchiera,
Albert D.M.E. Osterhausa, c,
Guus F. Rimmelzwaana, c
a Department of Virology, Erasmus MC, Rotterdam, The Netherlands
b Intensive Care and Department of Pediatric Surgery, Erasmus MC- Sophia Children's Hospital, Rotterdam, The Netherlands
c ViroClinics Biosciences, Rotterdam, The Netherlands
http://dx.doi.org/10.1016/j.vaccine.2012.04.086
Abstract
Annual vaccination of healthy children >6 months of age against seasonal influenza has been recommended by public health authorities of some countries. However, currently used seasonal vaccines provide only limited protection against (potentially) pandemic influenza viruses. Furthermore, we recently hypothesized that annual vaccination may hamper the development of cross-reactive immunity against influenza A viruses of novel subtypes, that would otherwise be induced by natural infection. Here we summarize our findings in animal models in which we demonstrated that vaccination against influenza A/H3N2 virus reduced the induction of heterosubtypic immunity against highly pathogenic avian influenza A/H5N1 virus, otherwise induced by a prior infection with influenza A/H3N2 virus. The reduction of heterosubtypic immunity correlated with reduced virus-specific CD8+ T cell responses. An additional study was performed in humans, in which we collected peripheral blood mononuclear cells from annually vaccinated children with cystic fibrosis (CF) and age-matched unvaccinated healthy control children to study the virus-specific T cell response. An age-related increase of the virus-specific CD8+ T cell response was observed in unvaccinated children that was absent in vaccinated children with CF. These findings highlight the importance of the development of vaccines that provide protection against influenza A viruses of all subtypes.
Highlights
► Annual vaccination of all children against flu is recommended in some countries. ► In animal models, H3N2-vaccination prevents heterosubtypic immunity against H5N1. ► Reduction of this immunity correlated with the reduction of flu-specific CTLs. ► Unvaccinated children had more flu-specific CTLs than vaccinated children with CF. ► These findings highlight the importance of the development of universal flu vaccines.
http://www.sciencedirect.com/science/article/pii/S0264410X12006329
Volume 30, Issue 51, 7 December 2012, Pages 7407?7410
Fourth ESWI Influenza Conference
Cover image
Annual influenza vaccination affects the development of heterosubtypic immunity
Rogier Bodewesa, Corresponding author contact information, E-mail the corresponding author,
Pieter L.A. Fraaija, b,
Joost H.C.M. Kreijtza,
Martina M. Geelhoed-Mierasa,
Ron A.M. Fouchiera,
Albert D.M.E. Osterhausa, c,
Guus F. Rimmelzwaana, c
a Department of Virology, Erasmus MC, Rotterdam, The Netherlands
b Intensive Care and Department of Pediatric Surgery, Erasmus MC- Sophia Children's Hospital, Rotterdam, The Netherlands
c ViroClinics Biosciences, Rotterdam, The Netherlands
http://dx.doi.org/10.1016/j.vaccine.2012.04.086
Abstract
Annual vaccination of healthy children >6 months of age against seasonal influenza has been recommended by public health authorities of some countries. However, currently used seasonal vaccines provide only limited protection against (potentially) pandemic influenza viruses. Furthermore, we recently hypothesized that annual vaccination may hamper the development of cross-reactive immunity against influenza A viruses of novel subtypes, that would otherwise be induced by natural infection. Here we summarize our findings in animal models in which we demonstrated that vaccination against influenza A/H3N2 virus reduced the induction of heterosubtypic immunity against highly pathogenic avian influenza A/H5N1 virus, otherwise induced by a prior infection with influenza A/H3N2 virus. The reduction of heterosubtypic immunity correlated with reduced virus-specific CD8+ T cell responses. An additional study was performed in humans, in which we collected peripheral blood mononuclear cells from annually vaccinated children with cystic fibrosis (CF) and age-matched unvaccinated healthy control children to study the virus-specific T cell response. An age-related increase of the virus-specific CD8+ T cell response was observed in unvaccinated children that was absent in vaccinated children with CF. These findings highlight the importance of the development of vaccines that provide protection against influenza A viruses of all subtypes.
Highlights
► Annual vaccination of all children against flu is recommended in some countries. ► In animal models, H3N2-vaccination prevents heterosubtypic immunity against H5N1. ► Reduction of this immunity correlated with the reduction of flu-specific CTLs. ► Unvaccinated children had more flu-specific CTLs than vaccinated children with CF. ► These findings highlight the importance of the development of universal flu vaccines.
http://www.sciencedirect.com/science/article/pii/S0264410X12006329