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Vaccinated Florida woman gives birth to first-known baby born with Covid antibodies

Treyfish

Treyfish

Moderator
Vaccinated Florida woman gives birth to first-known baby born with Covid antibodies

March 16,2021
?This is one small case in what will be thousands and thousands of babies born to mothers who have been vaccinated?
Andrew Buncombe
Seattle
@AndrewBuncombe
3 minutes ago
comments


A healthcare worker in Florida has given birth to a baby with Covid antibodies - the first known case of this happening after a person was vaccinated.

In a case that experts say could have significant implications for efforts to fight the pandemic, it was reported that the woman, had been vaccinated with the Moderna vaccine when she was 36 weeks pregnant.

She gave birth three weeks, in January, a blood sample was taken from the baby girl, and a DNA test was performed.

More follows.....:tiphat:https://www.independent.co.uk/news/...-moderna-antibodies-vaccination-b1818193.html
 
Doctors: Florida baby born with COVID-19 antibodies after mother vaccinated during pregnancy

Doctors: Florida baby born with COVID-19 antibodies after mother vaccinated during pregnancy
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7 News WSVN


PALM BEACH COUNTY, Fla. (WSVN) ? Doctors believe a baby who was recently born in Palm Beach County may be one of the first to have been born with COVID-19 anti-bodies after the mother had been vaccinated.

?To our knowledge, this was the first in the world that was reported of a baby being born with antibodies after a vaccination,? Dr. Paul Gilbert told WPBF.

Gilbert and Dr. Chad Rudnick said the baby?s mother is a front-line healthcare worker who was given the first dose of the Moderna vaccine when she was 36 weeks pregnant.
...
Their findings were discussed in an article in medRxiv, where they said although the infant had COVID-19 antibodies, further study is needed and infants born to vaccinated mothers could still be at risk.

?Further studies have to determine how long this protection will last,? Rudnick said. ?They have to determine at what level of protection or how many antibodies does a baby need to have circulating in order to give them protection.?

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:tiphat:https://wsvn.com/news/local/doctors...ies-after-mother-vaccinated-during-pregnancy/
 
Newborn Antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination

Paul Gilbert, View ORCID ProfileChad Rudnick
doi: https://doi.org/10.1101/2021.02.03.21250579
This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.
Abstract


Background Maternal vaccination for Influenza and TDaP have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against SARS-CoV-2 (the virus responsible for COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy. Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.

Case presentation A vigorous, healthy, full-term female was born to a COVID-19 na?ve mother who had received a single dose of mRNA vaccine for SARS-CoV-2 three weeks prior to delivery. Cord blood antibodies (IgG) were detected to the S-protein of SARS-CoV-2 at time of delivery.

Conclusion Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.
Background


Maternal vaccination for Influenza and TDaP have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against SARS-CoV-2 (the virus responsible for COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy. Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.
Methods


Maternal vaccination was provided to a COVID-19-na?ve front-line healthcare worker with the Moderna mRNA COVID-19 vaccine, at gestational age of 36 weeks 3 days. A normal, spontaneous vaginal birth occurred 3 weeks after dose 1 of the Moderna vaccine. The product of this 39 week 3 days gestation was a vigorous, healthy, full-term girl with normal newborn nursery course and subsequent well-infant evaluation. Under aseptic conditions and along with standard cord blood sampling for newborn blood type and direct antiglobulin test (DAT) a cord blood sample was taken immediately after birth and prior to placenta delivery with 0.5mL drawn into a red-top tube for serum. The serum was sent for SARS-CoV-2 antibody test to the S-protein as performed by Labcorp. The mother, who has been breastfeeding exclusively, then received the second dose of the Moderna vaccine during the post-partum period per the normal 28-day vaccination protocol timeline.

Results

Cord blood antibodies (IgG) were detected to SARS-CoV-2 at a level of 1.31 U/mL. This Electrochemiluminescence Immunoassay (ECLIA) uses a recombinant protein representing the RBD (receptor-binding domain) of the S antigen for the quantitative determination of antibodies against SARS-CoV-2[SUP]1[/SUP].


Discussion

Vaccination during pregnancy with TDaP and Flu is both well studied and formally recommended[SUP]2-5[/SUP]. The COVID-19 Pandemic and subsequent EUAs for two mRNA vaccines have created significant need for active research regarding safety and efficacy in pregnant and lactating mothers, as well as their offspring[SUP]6,7[/SUP].

The novel mRNA vaccines theoretically will demonstrate similar safety in this population, including placental passage of protective antibodies. Natural SARS-CoV-2 infection, however, seems to confer lower than expected passage of antibodies to the fetus which may indicate newborns born to vaccinated mothers will remain at risk for infection[SUP]8[/SUP].

We have demonstrated that SARS-CoV-2 IgG antibodies are detectable in a newborn?s cord blood sample after only a single dose of the Moderna COVID-19 vaccine. Thus, there is potential for protection and infection risk reduction from SARS-CoV-2 with maternal vaccination. Quantification of the antibody response can help to determine the specific antibody titer and aid in longitudinal monitoring of the dynamics of the antibody response in individual patients. Protective efficacy in newborns and ideal timing of maternal vaccination remains unknown. Further studies will be needed to quantify the amount of viral neutralizing antibodies present in babies born to SARS-CoV-2 na?ve mothers who are vaccinated prior to delivery. Additionally, the duration of antibody protection in this population is not yet known and serial total antibody measurements may be used to determine how long protection is expected which may help to determine when the best time would be to begin vaccination in newborns born to mothers who received a vaccine for SARS-CoV-2.

We urge other investigators to create pregnancy and breastfeeding registries as well as conduct efficacy and safety studies of the COVID-19 vaccines in pregnant and breastfeeding woman and their offspring.
References
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    Google Scholar:tiphat:https://www.medrxiv.org/content/10.1101/2021.02.03.21250579v1.full
 
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