tetano
Editor, Senior Moderator
Forsch Komplementmed. 2012;19(4):179-86. Epub 2012 Aug 20.
Utility of maoto in an influenza season where reduced effectiveness of oseltamivir was observed - a clinical, non-randomized study in children.
Toriumi Y, Kamei T, Murata K, Takahashi I, Suzuki N, Mazda O.
Source
Department of Pediatrics, Ohmura Hospital, Chiba, Japan.
Abstract
Background: In an influenza season where reduced effectiveness of oseltamivir was observed, we investigated the effectiveness of Maoto for influenza infection in children. Methods: Patients diagnosed with influenza by rapid diagnostic kit underwent treatment in one of the following groups: Maoto-treated group (group 1 (M)); oseltamivir-treated group (group 2 (O)); Maoto+oseltamivir-treated group (group 3 (M+O)); zanamivir-treated group (group 4 (Z)); and Maoto+zanamivir-treated group (group 5 (M+Z)). Results: In influenza A patients who completed the study (n = 150), the mean duration of fever after administration (DFA) was significantly shorter in group 3 (M+O) (31.1 h, p < 0.01) and in group 4 (Z) (35.2 h, p < 0.05), as compared to group 2 (O) (56.0 h). Among these, in patients aged ≤5 years (n = 54), DFA was significantly shorter in group 1 (M) (33.2 h, p < 0.05) and in group 3 (M+O) (34.6 h, p < 0.05), as compared to group 2 (O) (61.4 h). In influenza B patients who completed the study (n = 70), no significant differences in DFA were observed among the groups. Conclusion: Maoto may be useful, particularly in cases of influenza with low sensitivity to oseltamivir and in patients aged ≤5 years for whom the use of zanamivir is difficult.
Copyright ? 2012 S. Karger AG, Basel.
PMID:
22964983
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22964983
Utility of maoto in an influenza season where reduced effectiveness of oseltamivir was observed - a clinical, non-randomized study in children.
Toriumi Y, Kamei T, Murata K, Takahashi I, Suzuki N, Mazda O.
Source
Department of Pediatrics, Ohmura Hospital, Chiba, Japan.
Abstract
Background: In an influenza season where reduced effectiveness of oseltamivir was observed, we investigated the effectiveness of Maoto for influenza infection in children. Methods: Patients diagnosed with influenza by rapid diagnostic kit underwent treatment in one of the following groups: Maoto-treated group (group 1 (M)); oseltamivir-treated group (group 2 (O)); Maoto+oseltamivir-treated group (group 3 (M+O)); zanamivir-treated group (group 4 (Z)); and Maoto+zanamivir-treated group (group 5 (M+Z)). Results: In influenza A patients who completed the study (n = 150), the mean duration of fever after administration (DFA) was significantly shorter in group 3 (M+O) (31.1 h, p < 0.01) and in group 4 (Z) (35.2 h, p < 0.05), as compared to group 2 (O) (56.0 h). Among these, in patients aged ≤5 years (n = 54), DFA was significantly shorter in group 1 (M) (33.2 h, p < 0.05) and in group 3 (M+O) (34.6 h, p < 0.05), as compared to group 2 (O) (61.4 h). In influenza B patients who completed the study (n = 70), no significant differences in DFA were observed among the groups. Conclusion: Maoto may be useful, particularly in cases of influenza with low sensitivity to oseltamivir and in patients aged ≤5 years for whom the use of zanamivir is difficult.
Copyright ? 2012 S. Karger AG, Basel.
PMID:
22964983
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22964983