Gert van der Hoek
In Memoriam - Editor, Senior Moderator
A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer's disease
Mary T. Newport , Theodore B. VanItallie , Yoshihiro Kashiwaya , Michael Todd King , Richard L. Veech,
Alzheimer’s & Dementia - (2014) 1-5
Abstract
Background
Providing ketone bodies to the brain can bypass metabolic blocks to glucose utilization and improve function in energy-starved neurons. For this, plasma ketones must be elevated well above the ≤0.2 mM default concentrations normally prevalent. Limitations of dietary methods currently used to produce therapeutic hyperketonemia have stimulated the search for better approaches.
Method
Described herein is a new way to produce therapeutic hyperketonemia, entailing prolonged oral administration of a potent ketogenic agent—ketone monoester (KME)—to a patient with Alzheimer's disease dementia and a pretreatment Mini-Mental State Examination score of 12.
Results
The patient improved markedly in mood, affect, self-care, and cognitive and daily activity performance. The KME was well tolerated throughout the 20-month treatment period. Cognitive performance tracked plasma β-hydroxybutyrate concentrations, with noticeable improvements in conversation and interaction at the higher levels, compared with predose levels.
Conclusion
KME-induced hyperketonemia is robust, convenient, and safe, and the ester can be taken as an oral supplement without changing the habitual diet.
LINK TO FULL ARTICLE
For more information regarding the use of ketones and coconut oil : visit the website of the author: Mary T. Newport.
Steve's Clock Test - 2008
Mary T. Newport , Theodore B. VanItallie , Yoshihiro Kashiwaya , Michael Todd King , Richard L. Veech,
Alzheimer’s & Dementia - (2014) 1-5
Abstract
Background
Providing ketone bodies to the brain can bypass metabolic blocks to glucose utilization and improve function in energy-starved neurons. For this, plasma ketones must be elevated well above the ≤0.2 mM default concentrations normally prevalent. Limitations of dietary methods currently used to produce therapeutic hyperketonemia have stimulated the search for better approaches.
Method
Described herein is a new way to produce therapeutic hyperketonemia, entailing prolonged oral administration of a potent ketogenic agent—ketone monoester (KME)—to a patient with Alzheimer's disease dementia and a pretreatment Mini-Mental State Examination score of 12.
Results
The patient improved markedly in mood, affect, self-care, and cognitive and daily activity performance. The KME was well tolerated throughout the 20-month treatment period. Cognitive performance tracked plasma β-hydroxybutyrate concentrations, with noticeable improvements in conversation and interaction at the higher levels, compared with predose levels.
Conclusion
KME-induced hyperketonemia is robust, convenient, and safe, and the ester can be taken as an oral supplement without changing the habitual diet.
LINK TO FULL ARTICLE
For more information regarding the use of ketones and coconut oil : visit the website of the author: Mary T. Newport.
Steve's Clock Test - 2008
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