USA - H3N2 swine flu in 2 human cases, "vicinity" of pigs cited - CDC

[gsgs]

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

> The two cases of novel influenza A virus infection reported to CDC
> during 2010 were identified as swine influenza A (H3N2) virus
> and are unrelated to the 2009 pandemic influenza A (H1N1) virus..."

so just a normal triple-reassortant (1998) swine H3N2

humans had that H3 in ~1995 since then it continued to develope
in humans and independently in swine into another direction

30 years apart
like the 1976-vax against Mx

but in H3 antigenic evolution seems to be faster than in H1.

Fujian-flu 2003 had a new H3 only some years different
we get a new H3-vax every 3-5 years


but the elderly >80 years were well protected against Mx
from old infections <1940 .
That's ~30 years down the human lineage and then 100 years
up the swine-lineage, so ~130 years away !

 

[gsgs]

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

hmm, didn't we have tables recently, ferret antisera titers,
which did even include some of the old vaccine strains ?
mixin ?

CDC probably has tested this already ...

old vaccine strains: http://www.fludb.org/brc/vaccineRecommend.do?decorator=influenza



http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703974/

http://influenza.nhri.org.tw/ATIVS/



>A/swine/Missouri/02980/2010(H3N2)
MKTIIAFSYILCLIFAQKLPGSDNSMATLCIGHHAVPNGTLVKTITDDQIEVTNATELVQ
SSTTGRICNSPHKILDGKNCTLIDALLGDPHCDDFQNKEWDLFVERSTAYSNCYPYYVPD
YASLRSLVASSGTLEFNQESFNWTGVAQDGSSYACRRKSVNSFFSRLNWLHNLNYKYPAL
NVTMPNNDKFDKLYIWGVHHPGTDRDQTNLYVQASGRVTVSTKRGQQTVIPNIGSRPWIR
GVSSIISIYWTIVKPGDILLINSTGNLIAPRGYFKIQNGKSSIMRSDAPT

0% - low reactor to all

 

[sharon sanders]

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

Thanks Gsgs.

Of course, I would like the actual sequences from those 2 individuals released, if they have given permission, and also I would like to know the full epidemiology of these cases.

 

[Giuseppe]

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

November 8 2010 World Health Organization Influenza Update: http://www.flutrackers.com/forum/showpost.php?p=377874&postcount=1

Please, do not spread unneeded alarm.

H1 and H3 are almost the 'default' human influenza viruses, circulating without interruption since the beginning of XX century...

 

[sharon sanders]

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

I am asking for more information. I think that is prudent.

 

[alert]

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

Or not...

http://www.interfax.ru/society/news.asp?id=164518

Russian to English translation
New flu was discovered in the U.S., the threat is not - Onishchenko
Moscow. November 12. INTERFAX - Russian doctors have received from our American colleagues about the data that was discovered in the U.S. a new influenza virus is not dangerous.

A few days ago Russian doctors have learned through the World Health Organization (WHO) that in the U.S. for two people the virus H3N2, which is a triple-reassortant - is at once the three viruses that had previously been circulated.

"We have contacted the Centre for Communicable Disease Control in Atlanta. We have clarified the information published by WHO. From Atlanta received optimistic about the fact that influenza H3N1 does not have the properties of transmission from person to person", - has informed "Interfax" the head of Rospotrebnadzor , chief state sanitary doctor Gennady Onishchenko.

According to him, all registered in the U.S. cases of novel influenza occurred at the expense of transmission to man from pigs.

"From man to man, he is not transmitted. The human body for this strain is a dead end. It is a reliable indication that at this stage, this kind of strain to the epidemic spread will not" - said Gennady Onishchenko.

Nevertheless, he said, Rospotrebnadzor entrust national network of laboratories to study the probability of occurrence

This strain of influenza virus in Russia.

--------

http://news.am/rus/news/37843.html

November 12, 2010 | 03:05

Rumors that the world grows a new mutated flu virus H3N2 are fictitious and untrue. About it, told Armenian News - NEWS.am's chief epidemiologist Ara Asoyan.

"I have a few hours ago, returned from the USA, where he participated in a scientific conference. In Boston, epidemiologists have gathered from around the world. All of this nonsense, there is no flu. I repeat, I have just returned from the United States and responsibly declare it. If something like that happened, I would have known. Moreover, today no country in the world there is no flu epidemic, "said Asoyan. Summing up, the chief epidemiologist of Armenia said that it is too early to say even about the seasonal flu outbreaks: "The peak season of influenza, according to our observations, is yet to come - he will be in December-January."

It should be noted that in spite of such categorical statements of the Armenian epidemiologists, doctors around the world are sounding the alarm that the "Swine Flu» (H1N1) mutated, becoming a new virus H3N2.

At the moment the virus allegedly found in 7-month old girl in Illinois, USA, as well as in 46-year-old resident of Pennsylvania, wrote "Work".

Construction of a new virus is quite complicated - it consists of fragments of the genetic code of three different extracellular structures, but in general the code is different.

H1N1 virus was first discovered in 2009 in North America - U.S., Canada and Mexico, where the first cases were reported with fatal consequences. In April the same year the World Health Organization declared the epidemic of swine flu, gradually increasing the level of threat.

Subsequently, there was also an increasingly justified by the view that no "swine flu" in the world is not and was not, but these are just "tricks" of certain circles of the international structures in order to "cut the jackpot."

The scandal broke last year. Committee of the Parliamentary Assembly of the Council on Health published a report on the epidemic of so-called swine flu, or influenza H1N1.

Conclusion parliamentarians - scandalous: "Through the fault of the World Health Organization, the governments of the continent and the European institutions took place embezzlement of public funds, and inspire people unfounded fears."

Millions of packages purchased vaccine has not been used since the epidemic was limited.

The Council of Europe has discovered amazing facts: the alert was based on expert opinion, the names which the organization does not wish to disclose.
Listen
Read phonetically
Dictionary - View detailed dictionary

 

[gsgs]

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

Re: USA - H3N2 genetic change? Gennady Onishchenko - Health Officer of Russia says yes

but you post this as "alert" ;-)

this jumping from pigs to humans regularly happens
in North America, we have ~20 events since triple-reassortant-flu
developed in 1998

one of them made a pandemic

 

[Gert van der Hoek]

Re: USA - H3N2 genetic change? Not H2H

Re: USA - H3N2 genetic change? Not H2H

New flu virus in US not spread from human to human ? Onishchenko

12.11.2010,

MOSCOW, November 12 (Itar-Tass) - The new flu virus reported in the United States, a kind of modified AH3N2, is not spread from a human to a human, Gennady Onishchenko, chief of the Russian federal public health control agency (Rospotrebnadzor), told a press conference on Friday.

Fortunately, the "mutant" cannot be transferred from a human being to another human being, he assured.

Two cases have been reported in the United States -- a 46-year-old adult and a seven-month child.

The mutated virus consists of three "pieces" of various flu viruses. It already had come from a human to an animal and returned to a human again.

Itar-Tass

 

[Twall]

Re: USA - H3N2 genetic change? Not H2H says Onishchenko - Health Officer of Russia

Re: USA - H3N2 genetic change? Not H2H says Onishchenko - Health Officer of Russia

Via CDC From this link

November 12, 2010Reports of Human Infections with Swine Origin Influenza A (H3N2)


The November 12, 2010 FluView reports two human infections with swine origin influenza A (H3N2) viruses in the United States. Test samples from two patients submitted by Wisconsin and Pennsylvania have been confirmed at CDC as positive for swine origin triple-reassortant (tr) H3N2 influenza viruses?viruses that normally infect pigs. While human infection with swine influenza viruses is rare, it can occur. This is most likely to occur when people are in close proximity to infected pigs, such as in pig barns and livestock exhibits housing pigs at fairs. Both of the patients with confirmed trH3N2 infection reported in FluView were in the vicinity of live pigs. Dates of illness onset in the two patients are more than six weeks apart and the viruses from the two patients have some genetic differences, confirming that these two cases are not linked. Ongoing investigations in both states have not shown any evidence of community transmission of these viruses. The most likely scenario at this point is that these are two isolated cases of human infection with swine influenza viruses that, while very rare, do occur from time to time. Both patients have fully recovered from their illnesses; however, these two cases do underscore the importance of human and animal surveillance for influenza.

These two cases reported in FluView bring the total number of human infections with swine origin influenza viruses reported to CDC since 2005 to 18. Previously, three of these reports had been swine origin A (H3N2) viruses. The Pennsylvania and Wisconsin cases bring the number of reports swine origin A (H3N2) infections in humans in the United States to five. The viruses identified in Pennsylvania and Wisconsin are similar to viruses that infected a patient in Iowa in September 2009, a patient in Kansas in August 2009 and a patient in Minnesota in May 2010.

Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza viruses that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death rates in pigs. Swine influenza viruses may circulate among swine throughout the year, but most outbreaks occur during the late fall and winter months similar to outbreaks in humans. There are four main influenza type A virus subtypes that have been isolated in pigs: H1N1, H1N2, H3N2, and H3N1. Most flu viruses circulating in pigs are referred to as "triple-reassortant" viruses because these flu viruses contain genes from human, swine and avian influenza viruses.

Most commonly, cases of human infection with swine-origin influenza viruses occur in people with direct exposure to pigs. The patient in Pennsylvania lives in an area where live pigs are farmed and the patient in Wisconsin became sick two days after attending a state fair where pigs were exhibited. It's important to note that swine influenza viruses are not transmitted to humans by food. You can not get swine influenza from eating pork or pork products. Eating properly handled and cooked pork and pork products is safe.

In the past, CDC received reports of approximately one human infection with a swine influenza virus every one to two years, but in the past few years, about three cases have been reported per year. Increased reporting of human infections with swine influenza could be the result of increased influenza testing capacity and capabilities in public health laboratories.

These trH3N2 viruses are different from the 2009 H1N1 virus that has been circulating in the United States since late April 2009. They are also different from human seasonal influenza A (H3N2) viruses that typically circulate among people during the flu season. Swine trH3N2 viruses commonly circulate in pigs in North America, but rarely infect humans. These viruses are different from the swine classical H1N1 or swine trH1N1 influenza viruses that also circulate in pigs in North America because they have H3N2 surface antigens. Tr H3N2 viruses first emerged in North American swine herds in the late 1990s. The H3 and N2 genes which first emerged in swine flu viruses originated from human seasonal H3N2 influenza viruses that circulated globally among humans in the late 1990s.

Although the vast majority of instances of human infection with animal influenza viruses do not result in human to human transmission, each case should be fully investigated to be sure that such viruses are not spreading among humans and to limit further exposure of humans to infected animals if infected animals are identified. Surveillance for both seasonal and novel influenza viruses is conducted by the CDC and its state and local health partners year round.

For more information about swine influenza, visit http://www.cdc.gov/flu/swineflu/

Weekly U.S. surveillance updates are published in FluView and posted at http://www.cdc.gov/flu/weekly/fluactivitysurv.htm

 

[sharon sanders]

Re: USA - H3N2 genetic change? Not H2H says Onishchenko - Health Officer of Russia

Re: USA - H3N2 genetic change? Not H2H says Onishchenko - Health Officer of Russia

"While human infection with swine influenza viruses is rare, it can occur. This is most likely to occur when people are in close proximity to infected pigs, such as in pig barns and livestock exhibits housing pigs at fairs. Both of the patients with confirmed trH3N2 infection reported in FluView were in the vicinity of live pigs. Dates of illness onset in the two patients are more than six weeks apart and the viruses from the two patients have some genetic differences, confirming that these two cases are not linked. Ongoing investigations in both states have not shown any evidence of community transmission of these viruses. The most likely scenario at this point is that these are two isolated cases of human infection with swine influenza viruses that, while very rare, do occur from time to time."


"In the past, CDC received reports of approximately one human infection with a swine influenza virus every one to two years, but in the past few years, about three cases have been reported per year. Increased reporting of human infections with swine influenza could be the result of increased influenza testing capacity and capabilities in public health laboratories."

 

[sharon sanders]

Re: USA - H3N2 genetic change? Not H2H says Onishchenko - Health Officer of Russia

Re: USA - H3N2 genetic change? Not H2H says Onishchenko - Health Officer of Russia

As always, time will tell.

We monitor influenza activity all over the world, including influenza like illness, pneumonia, and other diseases that can be misdiagnosed such as dengue, tuberculosis, respiratory diseases, and others, when the actual ailment is flu.

We will be monitoring this novel flu strain along with A/H1N1 and A/H5N1 and will post all developments on the site.

 

[gsgs]

Re: USA - H3N2 genetic change? Not H2H says Onishchenko - Health Officer of Russia

Re: USA - H3N2 genetic change? Not H2H says Onishchenko - Health Officer of Russia

now some double infection, reassortment, voila.

Maybe we should kep that H3-vax ready,
so it could be produced in masses quickly.

Surveillance in USA is better than in Mexico, so another
outreak as in 2009 might be stopped at its source

Keeping some million doses of vax available to immunize
a region.

We also have H3N2 in swine in Asia,Europe,
reassorting with Eurasian H1N1 and ***

 

[alert]

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

I guess the Wisconsin case is the one errantly identified by Onischenko as from Illinois.

http://www.cdc.gov/flu/weekly/

Novel Influenza A Virus:
Two cases of human infection with a novel influenza A virus were reported: one case by the Wisconsin Department of Health Services and one case by the Pennsylvania Department of Health. Both patients were infected with a swine origin influenza A (H3N2) virus similar to the three other swine origin influenza A (H3N2) viruses previously identified in 2009 and 2010. The Wisconsin case reported contact with pigs in the week preceding symptom onset on September 8, 2010 and required hospitalization. No contact with pigs has been identified in the Pennsylvania case in the week before symptom onset on October 24, 2010; however the case lives in an area close to pig farms. Both patients have fully recovered from their illness. The cases are not related and the viruses from these two cases have some genetic differences, indicating that they did not come from the same source.

Although both investigations are ongoing, there is no evidence of human-to-human transmission with this virus in either case. Early identification and investigation of human infections with novel influenza A viruses is critical to evaluate the extent of the outbreak and possible human-to-human transmission. Surveillance for human infections with novel influenza A viruses continues year round.

 

[alert]

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

http://afludiary.blogspot.com/

Friday, November 12, 2010
CDC: Statement On Swine H3N2 Influenza

# 5051

Over the past 72 hours there has been quite a bit of speculation on the internet regarding 2 recent cases of H3N2 swine influenza contracted by people in different states.

Long time readers of this blog know that while rare, we occasionally will see a novel swine influenza virus jump to humans.

Although the 2009 swine flu pandemic was an exception, most of the time this turns out to be a one-off dead-end transmission, and goes no further.

Which is why – while I was aware of these cases two days ago - with scant details available, I opted to wait until we could get something more reliable than simple conjecture before mentioning them in this blog.

One case was reported in a line item in this week’s MMWR as a novel H3N2 infection in Pennsylvania, although little else was provided.

Today, the CDC has released a comprehensive statement which I am reproducing below.

Read the whole statement - but for those who prefer the condensed version - I’ve extracted the main points (underscores mine), which are:

Dates of illness onset in the two patients are more than six weeks apart and the viruses from the two patients have some genetic differences, confirming that these two cases are not linked.

Ongoing investigations in both states have not shown any evidence of community transmission of these viruses. The most likely scenario at this point is that these are two isolated cases of human infection with swine influenza viruses that, while very rare, do occur from time to time

November 12, 2010
Reports of Human Infections with Swine Origin Influenza A (H3N2)
The November 12, 2010 FluView reports two human infections with swine origin influenza A (H3N2) viruses in the United States. Test samples from two patients submitted by Wisconsin and Pennsylvania have been confirmed at CDC as positive for swine origin triple-reassortant (tr) H3N2 influenza viruses—viruses that normally infect pigs. While human infection with swine influenza viruses is rare, it can occur. This is most likely to occur when people are in close proximity to infected pigs, such as in pig barns and livestock exhibits housing pigs at fairs. Both of the patients with confirmed trH3N2 infection reported in FluView were in the vicinity of live pigs. Dates of illness onset in the two patients are more than six weeks apart and the viruses from the two patients have some genetic differences, confirming that these two cases are not linked. Ongoing investigations in both states have not shown any evidence of community transmission of these viruses. The most likely scenario at this point is that these are two isolated cases of human infection with swine influenza viruses that, while very rare, do occur from time to time. Both patients have fully recovered from their illnesses; however, these two cases do underscore the importance of human and animal surveillance for influenza.

These two cases reported in FluView bring the total number of human infections with swine origin influenza viruses reported to CDC since 2005 to 18. Previously, three of these reports had been swine origin A (H3N2) viruses. The Pennsylvania and Wisconsin cases bring the number of reports swine origin A (H3N2) infections in humans in the United States to five. The viruses identified in Pennsylvania and Wisconsin are similar to viruses that infected a patient in Iowa in September 2009, a patient in Kansas in August 2009 and a patient in Minnesota in May 2010.

Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza viruses that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death rates in pigs. Swine influenza viruses may circulate among swine throughout the year, but most outbreaks occur during the late fall and winter months similar to outbreaks in humans. There are four main influenza type A virus subtypes that have been isolated in pigs: H1N1, H1N2, H3N2, and H3N1. Most flu viruses circulating in pigs are referred to as "triple-reassortant" viruses because these flu viruses contain genes from human, swine and avian influenza viruses.

Most commonly, cases of human infection with swine-origin influenza viruses occur in people with direct exposure to pigs. The patient in Pennsylvania lives in an area where live pigs are farmed and the patient in Wisconsin became sick two days after attending a state fair where pigs were exhibited. It's important to note that swine influenza viruses are not transmitted to humans by food. You can not get swine influenza from eating pork or pork products. Eating properly handled and cooked pork and pork products is safe.

In the past, CDC received reports of approximately one human infection with a swine influenza virus every one to two years, but in the past few years, about three cases have been reported per year. Increased reporting of human infections with swine influenza could be the result of increased influenza testing capacity and capabilities in public health laboratories.

These trH3N2 viruses are different from the 2009 H1N1 virus that has been circulating in the United States since late April 2009. They are also different from human seasonal influenza A (H3N2) viruses that typically circulate among people during the flu season. Swine trH3N2 viruses commonly circulate in pigs in North America, but rarely infect humans. These viruses are different from the swine classical H1N1 or swine trH1N1 influenza viruses that also circulate in pigs in North America because they have H3N2 surface antigens. Tr H3N2 viruses first emerged in North American swine herds in the late 1990s. The H3 and N2 genes which first emerged in swine flu viruses originated from human seasonal H3N2 influenza viruses that circulated globally among humans in the late 1990s.

Although the vast majority of instances of human infection with animal influenza viruses do not result in human to human transmission, each case should be fully investigated to be sure that such viruses are not spreading among humans and to limit further exposure of humans to infected animals if infected animals are identified. Surveillance for both seasonal and novel influenza viruses is conducted by the CDC and its state and local health partners year round.

For more information about swine influenza, visit http://www.cdc.gov/flu/swineflu/

Posted by Michael Coston at 12:23 PM 0 comments Links to this post

 

[alert]

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

http://www.promedmail.org/pls/apex/..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,85806

Archive Number 20101112.4117
Published Date 12-NOV-2010
Subject PRO/AH/EDR> Influenza (14): swine origin (tr) H3N2 viruses


INFLUENZA (14): SWINE ORIGIN (TRIPLE REASSORTANT) H3N2 VIRUSES
**************************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Fri 12 Nov 2010
Source: CDC Online Newsroom [edited]
<http://www.cdc.gov/media/subtopic/heard.htm#h3n2>


Reports of human infections with swine origin influenza A (H3N2)
----------------------------------------------------------------
The 12 Nov 2010 FluView reports 2 human infections with swine origin
influenza A (H3N2) viruses in the United States. Test samples from 2
patients submitted by Wisconsin and Pennsylvania have been confirmed at the
CDC [Centers for Disease Control and Prevention] as positive for swine
origin triple-reassortant (tr) H3N2 influenza viruses -- viruses that
normally infect pigs. While human infection with swine influenza viruses is
rare, it can occur. This is most likely to occur when people are in close
proximity to infected pigs, such as in pig barns and livestock exhibits
housing pigs at fairs.

Both of the patients with confirmed trH3N2 infection reported in FluView
were in the vicinity of live pigs. Dates of illness onset in the 2 patients
are more than 6 weeks apart and the viruses from the 2 patients have some
genetic differences, confirming that these 2 cases are not linked. Ongoing
investigations in both states have not shown any evidence of community
transmission of these viruses. The most likely scenario at this point is
that these are 2 isolated cases of human infection with swine influenza
viruses that, while very rare, do occur from time to time. Both patients
have fully recovered from their illnesses; however, these 2 cases do
underscore the importance of human and animal surveillance for influenza.

These 2 cases reported in FluView bring the total number of human
infections with swine origin influenza viruses reported to CDC since 2005
to 18. Previously, 3 of these reports had been swine origin A (H3N2)
viruses. The Pennsylvania and Wisconsin cases bring the number of reports
swine origin A (H3N2) infections in humans in the United States to 5. The
viruses identified in Pennsylvania and Wisconsin are similar to viruses
that infected a patient in Iowa in September 2009, a patient in Kansas in
August 2009 and a patient in Minnesota in May 2010.

Swine Influenza (swine flu) is a respiratory disease of pigs caused by type
A influenza viruses that regularly causes outbreaks of influenza in pigs.
Swine flu viruses cause high levels of illness and low death rates in pigs.
Swine influenza viruses may circulate among swine throughout the year, but
most outbreaks occur during the late fall and winter months similar to
outbreaks in humans. There are 4 main influenza type A virus subtypes that
have been isolated in pigs: H1N1, H1N2, H3N2, and H3N1. Most flu viruses
circulating in pigs are referred to as "triple-reassortant" viruses because
these flu viruses contain genes from human, swine and avian influenza viruses.

Most commonly, cases of human infection with swine-origin influenza viruses
occur in people with direct exposure to pigs. The patient in Pennsylvania
lives in an area where live pigs are farmed and the patient in Wisconsin
became sick 2 days after attending a state fair where pigs were exhibited.
It's important to note that swine influenza viruses are not transmitted to
humans by food. You can not get swine influenza from eating pork or pork
products. Eating properly handled and cooked pork and pork products is safe.

In the past, CDC received reports of approximately one human infection with
a swine influenza virus every one to 2 years, but in the past few years,
about 3 cases have been reported per year. Increased reporting of human
infections with swine influenza could be the result of increased influenza
testing capacity and capabilities in public health laboratories.

These trH3N2 viruses are different from the 2009 H1N1 virus that has been
circulating in the United States since late April 2009. They are also
different from human seasonal influenza A (H3N2) viruses that typically
circulate among people during the flu season. Swine trH3N2 viruses commonly
circulate in pigs in North America, but rarely infect humans. These viruses
are different from the swine classical H1N1 or swine trH1N1 influenza
viruses that also circulate in pigs in North America because they have H3N2
surface antigens. Tr H3N2 viruses first emerged in North American swine
herds in the late 1990s. The H3 and N2 genes which 1st emerged in swine flu
viruses originated from human seasonal H3N2 influenza viruses that
circulated globally among humans in the late 1990s.

Although the vast majority of instances of human infection with animal
influenza viruses do not result in human to human transmission, each case
should be fully investigated to be sure that such viruses are not spreading
among humans and to limit further exposure of humans to infected animals if
infected animals are identified. Surveillance for both seasonal and novel
influenza viruses is conducted by the CDC and its state and local health
partners year round.

For more information about swine influenza, see:
<http://www.cdc.gov/flu/swineflu/>.
Weekly US surveillance updates are published in FluView and posted at:
<http://www.cdc.gov/flu/weekly/fluactivitysurv.htm>.

--
communicated by:
ProMED-mail Rapporteur Mary Marshall

[There are 4 main influenza type A virus subtypes that have been isolated
in pigs: H1N1, H1N2, H3N2, and H3N1. Most flu viruses circulating in pigs
are referred to as "triple-reassortant" viruses because these flu viruses
contain genes from human, swine, and avian influenza viruses.

Swine triple-reassortant H3N2 influenza viruses commonly circulate in pigs
in North America, but rarely infect humans. The total number of human
infections with swine origin influenza viruses reported to the CDC since
2005 had been 16, and 3 of these reports had been swine origin A (H3N2)
viruses. The Pennsylvania and Wisconsin cases described above bring the
number of reports swine origin A (H3N2) infections in humans in the United
States to 5, and the total of swine origin A influenza A viruses to 18.

The dates of illness onset in the 2 patients are more than 6 weeks apart
and the viruses from the 2 patients have some genetic differences,
confirming that these 2 cases are not linked.

Swine flu viruses cause high levels of illness and low death rates in pigs.
Swine influenza viruses may circulate among swine throughout the year, but
most outbreaks occur during the late fall and winter months similar to
outbreaks in humans.

Transmission of swine (tr) influenza a viruses to humans has been rare,
even in individuals occupationally exposed to pigs. With the exception of
the swine-origin A (H1N1) 2009 pandemic virus human-to-human transmission
has occurred rarely, if at all.

The HealthMap/ProMED-mail interactive map of the United States, showing the
locations of the states of Pennsylvania and Wisconsin, can be accessed at
<http://healthmap.org/r/01bQ>. - Mod.CP]

 

[gsgs]

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

would they please try to reassort them with Mx in pigs
(and human H3N2 in mice,ferrets)

BTW. can someone remove the side-scroll in this thread ?

must be the table in #6, link only now ?

 

[gsgs]

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

so, this is presumably how *** started.
One of the rare occurrances of pig2human
but that virus could transmit h2h.

And this happened, _although_ p2h is so rare.

So, there could be many strains out there with
pandemic potential and just occasionally, rarely,
do we see one.

Hey, ter rorists, Gates, did you read this ?

 

[Laidback Al]

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

Re: USA - H3N2 swine flu in 2 human cases not related, "vicinity" of pigs cited - CDC

BTW. can someone remove the side-scroll in this thread ?

must be the table in #6, link only now ?

Done.