tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2015 Dec 11. [Epub ahead of print]
[h=1]Uptake and Effectiveness of a Trivalent Inactivated Influenza Vaccine in Children in Urban and Rural Kenya, 2010-2012.[/h] Katz MA[SUP]1[/SUP], Lebo E, Emukule GO, Otieno N, Caselton DL, Bigogo G, Njuguna H, Muthoka PM, Waiboci LW, Widdowson MA, Xu X, Njenga MK, Mott JA, Breiman RF.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] In Africa, recent surveillance has demonstrated a high burden of influenza, but influenza vaccine is rarely used. In Kenya, a country with a tropical climate, influenza has been shown to circulate year-round, like in other tropical countries.
[h=4]METHODS:[/h] During three months in 2010 and 2011, and two months in 2012, the Kenya Medical Research Institute/CDC-Kenya offered free injectable trivalent inactivated influenza vaccine to children 6 months-10 years old in two resource-poor communities in Kenya - Kibera andLwak (total population ~50,000). We conducted a case-control study to evaluate vaccine effectiveness (VE)in preventing laboratory-confirmed influenza associated with influenza-like illness and acute lower respiratory illness.
[h=4]RESULTS:[/h] Of 52,000 eligible children, 41%, 48%, and 51% received at least one vaccine in 2010, 2011, and 2012, respectively; 30%, 36%, and 38% were fully vaccinated. VE among fully vaccinated children was 57% (95% CI = 29-74%) during a 6-month follow-up period, 39% (95% CI = 17-56%) during a 9-month follow-up period, and 48% (95% CI = 32-61%) during a 12-month follow-up period. For the 12-month follow-up period, VE was statistically significant in children < 5 years and children 5 years old < 10 years old (50% and 46%, respectively).
[h=4]CONCLUSIONS:[/h] In Kenya, parents of nearly half of eligible children under 10 years old chose to get their children vaccinated with a free influenza vaccine. During a 12-month follow-up period the vaccine was moderately effective in preventing medically attended influenza-associated respiratory illness.
PMID: 26658627 [PubMed - as supplied by publisher]
[h=1]Uptake and Effectiveness of a Trivalent Inactivated Influenza Vaccine in Children in Urban and Rural Kenya, 2010-2012.[/h] Katz MA[SUP]1[/SUP], Lebo E, Emukule GO, Otieno N, Caselton DL, Bigogo G, Njuguna H, Muthoka PM, Waiboci LW, Widdowson MA, Xu X, Njenga MK, Mott JA, Breiman RF.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] In Africa, recent surveillance has demonstrated a high burden of influenza, but influenza vaccine is rarely used. In Kenya, a country with a tropical climate, influenza has been shown to circulate year-round, like in other tropical countries.
[h=4]METHODS:[/h] During three months in 2010 and 2011, and two months in 2012, the Kenya Medical Research Institute/CDC-Kenya offered free injectable trivalent inactivated influenza vaccine to children 6 months-10 years old in two resource-poor communities in Kenya - Kibera andLwak (total population ~50,000). We conducted a case-control study to evaluate vaccine effectiveness (VE)in preventing laboratory-confirmed influenza associated with influenza-like illness and acute lower respiratory illness.
[h=4]RESULTS:[/h] Of 52,000 eligible children, 41%, 48%, and 51% received at least one vaccine in 2010, 2011, and 2012, respectively; 30%, 36%, and 38% were fully vaccinated. VE among fully vaccinated children was 57% (95% CI = 29-74%) during a 6-month follow-up period, 39% (95% CI = 17-56%) during a 9-month follow-up period, and 48% (95% CI = 32-61%) during a 12-month follow-up period. For the 12-month follow-up period, VE was statistically significant in children < 5 years and children 5 years old < 10 years old (50% and 46%, respectively).
[h=4]CONCLUSIONS:[/h] In Kenya, parents of nearly half of eligible children under 10 years old chose to get their children vaccinated with a free influenza vaccine. During a 12-month follow-up period the vaccine was moderately effective in preventing medically attended influenza-associated respiratory illness.
PMID: 26658627 [PubMed - as supplied by publisher]