tetano
Editor, Senior Moderator
Fundam Clin Pharmacol. 2016 Jun 25. doi: 10.1111/fcp.12213. [Epub ahead of print]
[h=1]Unexpected platelets elevation in a patient with idiopathic thrombocytopenia treated with oseltamivir for influenza infection.[/h] Bigot P[SUP]1[/SUP], Auffret M[SUP]2[/SUP], Gautier S[SUP]2[/SUP], Weinborn M[SUP]3[/SUP], Ettahar NK[SUP]4[/SUP], Coup? P[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Oseltamivir is a neuraminidase inhibitor approved for the prevention and treatment of influenza. Few hematological side effects of oseltamivir have been reported. We report herein the case of an unexpected platelet increase in a 46-year-old woman with idiopathic thrombocytopenia treated with oseltamivir for influenza. The mechanism may involve the neuraminidase inhibition which decrease platelet surface sialic acid content and reduce their removal by the reticuloendothelial system. Oseltamivir may be responsible for platelet increase especially in patients with idiopathic thrombocytopenia. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; Oseltamivir; drug induced; idiopathic thrombocytopenia; platelet count
PMID: 27343486 DOI: 10.1111/fcp.12213
[PubMed - as supplied by publisher]
[h=1]Unexpected platelets elevation in a patient with idiopathic thrombocytopenia treated with oseltamivir for influenza infection.[/h] Bigot P[SUP]1[/SUP], Auffret M[SUP]2[/SUP], Gautier S[SUP]2[/SUP], Weinborn M[SUP]3[/SUP], Ettahar NK[SUP]4[/SUP], Coup? P[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Oseltamivir is a neuraminidase inhibitor approved for the prevention and treatment of influenza. Few hematological side effects of oseltamivir have been reported. We report herein the case of an unexpected platelet increase in a 46-year-old woman with idiopathic thrombocytopenia treated with oseltamivir for influenza. The mechanism may involve the neuraminidase inhibition which decrease platelet surface sialic acid content and reduce their removal by the reticuloendothelial system. Oseltamivir may be responsible for platelet increase especially in patients with idiopathic thrombocytopenia. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; Oseltamivir; drug induced; idiopathic thrombocytopenia; platelet count
PMID: 27343486 DOI: 10.1111/fcp.12213
[PubMed - as supplied by publisher]