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Underlying conditions - what to do?

AlaskaDenise

In Memoriam
I’m tired of reading reports about novel H1N1 severe illness and death followed by the comment - “they had underlying conditions.” It sounds like victim blaming, or worse yet, eugenics. An asthmatic child is just as entitled to be fully healthy as a child with normal lungs.

So how are people with “underlying conditions” supposed to lessen their chances of severe influenza or death? The medical community doesn’t seem to be supplying any guidance, so why not use the collective knowledge here at FT? Below is a list of “risk factors” and some of my initial comments regarding prevention. Please add relevent information. I'll update this first post as information comes in.


General Guidance:
1) Vitamin D levels should be 50 ng/ml. Get 15-20 minutes of daily sun exposure when UV index>3.5 or take at least 5000 IU of Vitamin D3.
2) Get a pneumovax shot to prevent pneumonia complications.
3) If you suspect you've contracted novel H1N1, seek anti-viral treatment within 36 hours.

Chronic pulmonary disease (Asthma, COPD, etc.) - preventer inhaler

Any condition that compromises handling of respiratory secretions (cerebral palsy, etc.)

Smoking - stop smoking

Pregnancy - avoid sick people and school age children. If exposed in 2nd or 3rd trimester seek antiviral prophylaxis with Zanimirvir (per CDC).

Immune system disorders (immunosuppressive therapy, HIV, cancer chemotherapy, etc.) - if undergoig chemotherapy, take Neulasta to prevent neutropenia;
CoQ10 to improve immune system

Active malignancy

Chronic renal insufficiency

Chronic liver disease

Heart Disease - red wine and peanuts; maintain oral hygiene (brushing and flossing) to avoid exacerbation of existing heart conditions.

Hemoglobinopathies (such as sickle cell disease)

Diabetes mellitus

Obesity - get BMI<30, 45 min of exercise 3-4 times/week

Childhood malnutrition and dehydration (from prolonged vomiting and diarrhea)

Childhood metabolic disorder (cannot tolerate prolonged fasting)


others???

.
 
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Re: Underlying conditions - what to do?

Asthma - a preventer inhaler

Heart disease - a nice glass of red wine and peanuts daily - for resveratrol.

I have found that Sambucol, suggested by Shannon years ago, works on every influenza that our family has ever had - to reduce symptoms and length of illness.
 
Re: Underlying conditions - what to do?

Re: Immune system: Coenzyme Q10

I got my employer to pay for an extensive class on immune system function and enhancement. CQ10 is what I came away with as the most useful.
My last bout with influenza (and I have had a number of very bad experiences with viruses) was remarkedly unremarkable, and I credit CQ10.
I do not have time right now to go into the science why, maybe later if someone else does not provide the info.! :D
 
Re: Underlying conditions - what to do?

Thanks for your input. I updated the first post with the information.

I'll add a pneumovax shot.

I'm hoping we can get information for people who may not have insurance or may not be able to afford expensive medicines. We allready did this with Vitamin D, so it might prove useful if we can compile data by condition.

.
 
Re: Underlying conditions - what to do?

I've heard a good deal about probiotics, replacement formulations for gut flora, and their considerable role in immune function enhancement. Does anyone have knowledge or citations to back this up?
 
Re: Underlying conditions - what to do?

Yes, those "good germs" that have a benefit to humans!

see: http://users.rcn.com/jkimball.ma.ul...Pathogen-Associated_Molecular_Patterns_(PAMPs)

The innate immune system and commensal bacteria

The human large intestine (colon) contains an enormous (~1014) population of microorganisms. (Our bodies consist of only ~1013 cells!) Most of the species live there perfectly harmlessly; that is, they are commensals. Some are actually beneficial, e.g.,

?by synthesizing vitamins;
?by digesting polysaccharides for which we have no enzymes (providing an estimated 10% of the calories we acquire from our food);
?by stimulating the development of the adaptive immune system, including Th1 helper cells (which then inhibit Th2 helper cells which may provide protection against allergies like asthma). [Link]

Despite the name ("pathogen-associated"), PAMPs are found on all these nonpathogenic bacteria as well.

It turns out that not only do these bacteria not trigger inflammation, but their presence is needed (at least in mice) to maintain a healthy colon.

?Mice that are raised in a germfree environment [Link] or are treated with antibiotics to clean all the bacteria out of their colon are unhealthy and have G.I. tracts that are hypersensitive to injury. However, if they are given
◦LPS (from Gram-negative bacteria) or
◦lipoteichoic acid (from the peptidoglycan of Gram-positive bacteria)
in their drinking water, their colons resist injury.
?However, "knockout" mice that
◦lack TLR-2 or TLR-4 or
◦cannot signal through their TLRs [Link]
are not protected by such treatment.

These results

?suggest that a continuous low level of activity of the innate immune system is essential to health ? even in the absence of pathogens;
?explain why deliberating feeding harmless bacteria ("probiotics") has proved beneficial to some human patients with a diseased colon;
?provide another reason for avoiding the indiscriminate use of antibiotics (which kill harmless bacteria as easily as pathogenic ones).

.
 
Re: Underlying conditions - what to do?

While some of the general preventative information we've discussed elsewhere applies to underlying conditions, I'm hoping we can organize both that information and condition-specific information in this thread.

I'm continuing to look for specific guidance for underlying conditions and I'm not finding much of anything. There must be some out there.

.
 
Re: Underlying conditions - what to do?

...by stimulating the development of the adaptive immune system, including Th1 helper cells (which then inhibit Th2 helper cells which may provide protection against allergies like asthma). [Link]

Are they saying that sufficient appropriate bacteria in the colon help protect against asthma? I get confused when I try to understand the T-cells, B-cells, etc.

If that inference is true, we can add probiotics for Asthma.

.
 
Re: Underlying conditions - what to do?

I've heard a good deal about probiotics, replacement formulations for gut flora, and their considerable role in immune function enhancement. Does anyone have knowledge or citations to back this up?

I first read about acidophilus as an important factor for viral immunity in our various mucosal tissues, in 1972 and have been a believer ever since.

Here's a medical site about preventing flu in diabetics. It mentions probiotics, among other things.

(snipped)


Probiotics: Lactobacillus

Although not a nutrient per se, probiotic bacteria are critical to healthy immune function. Because the cellular linings of our body are where we are susceptible to viral infection - places like our mouth, nose, and digestive tract - it is important to keep them healthy. These linings are literally alive with bacteria - some good, some infectious - and the good ones help regulate our immune defenses against infection.

Lactic acid bacteria, like Lactobacillus species, appear to help regulate mucosal immunity by increasing antibody production against viruses, including the influenza virus, improving natural resistance to infection [16]. In addition, animal experiments have shown giving mice Lactobacillus reduced viral levels, and prevented infection [17]. Some Lactobacillus species appear to increase the effectiveness of the influenza vaccine [18].

In diabetes, maintaining normal mucosal health is challenged in other ways. As described in Complementary Corner September 2006, high blood glucose increases the chances of mucosal and bowel overgrowth of unhealthy bacteria! The effect of these probiotics on flu prevention in diabetes deserves research attention because diabetes is a risk factor for death and hospitalization from the flu, is associated with altered mucosal immunity, and because Lactobacillus species appear to impact viral transmission.

http://www.diabetesaction.org/site/PageNavigator/Complementary Corner/complementary_11_08
 
Re: Underlying conditions - what to do?

Great info AlaskaDenise. I guess you could add brushing your teeth to lower bacterial loads. I did wonder about mouthwash (non alcoholic of course). Would that help too?

Hygiene first. There was a lot of gargling going on in 1918, but Rice suspects that it did more harm than good. But a study in Japan during a flu outbreak two years ago found that those who made a point of brushing their teeth and their tongue a few times a day reduced the flu?s severity. It was compared with keeping a doorstep swept.
http://www.flutrackers.com/forum/showthread.php?t=102843

Not touching your face is another strategy. Simple but effective.
 
Re: Underlying conditions - what to do?

Are they saying that sufficient appropriate bacteria in the colon help protect against asthma? I get confused when I try to understand the T-cells, B-cells, etc.

If that inference is true, we can add probiotics for Asthma.

.

It is just a reference to the ?hygiene hypothesis?. Probiotics cannot cure asthma, but exposure to bacteria from an early age may condition the immune system to be less likely to develop in an allergic mode, thus the individual may be at reduced risk to develop allergic asthma.

For more information:
http://www.sciencenews.org/pages/sn_arc99/8_14_99/bob2.htm
 
Re: Underlying conditions - what to do?

Great info AlaskaDenise. I guess you could add brushing your teeth to lower bacterial loads. I did wonder about mouthwash (non alcoholic of course). Would that help too?......

The connection between cardiovascular disease and periodontal disease is documented. See: http://www.perio.org/consumer/mbc.heart.htm

(snipped)

Periodontal disease can also exacerbate existing heart conditions

I'll add dental hygiene to the list for cardiovascular disease.

.
 
Re: Underlying conditions - what to do?

For anyone undergoing chemotherapy, they should consider taking Neulasta to stimulate their immune system and prevent neutropenia.

http://www.medicalnewstoday.com/articles/9925.php

(snipped)

...administration of Neulasta(reg) (pegfilgrastim) in the first and subsequent cycles of chemotherapy significantly lowers the rate of infection, as manifested by febrile neutropenia (low white blood cell count with fever), hospitalization and the use of intravenous anti-infectives in breast cancer patients receiving moderately myelosuppressive (strong) chemotherapy...

.
 
Re: Underlying conditions - what to do?

I have mentioned this previously - but it has no scientific base - just observation. I had a friend who underwent chemotherapy for nearly 7 years, on and off. Whenever he and his wife had to go out into the world they would get home and breath the vapours of a steaming bowl of water with a little tea tree oil in it. They did not get a flu or cold once in this time.
 
Re: Underlying conditions - what to do?

I believe there is science behind the benefits of Neulasta, otherwise insurance companies wouldn't pay for it. Some patients with high co-pays opt not to get it because of the $3000+/use price. If it can avoid even one hospital stay, it pays for itself, in addition to ensuring that the cancer treatment is effective by getting treatment on schedule. In addition to neulasta, chemo patients are advised to follow good hygiene & some social distancing, just like we all should do during an influenza pandemic.

I would never suggest to anyone to not utilize Neulasta, if they are able to do so. The high cost and constant bone pain are better than the alternative.

.
 
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