tetano
Editor, Senior Moderator
Trends Genet
. 2020 Aug 10;S0168-9525(20)30203-1.
doi: 10.1016/j.tig.2020.08.003. Online ahead of print.
Host Polymorphisms May Impact SARS-CoV-2 Infectivity
Patrick Brest[SUP] 1 [/SUP], Sadal Refae[SUP] 2 [/SUP], Baharia Mograbi[SUP] 1 [/SUP], Paul Hofman[SUP] 3 [/SUP], Gerard Milano[SUP] 4 [/SUP]
Affiliations
Abstract
Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected.
Keywords: SNP; coronavirus; genetic variation; infection; pharmacogenetics.
. 2020 Aug 10;S0168-9525(20)30203-1.
doi: 10.1016/j.tig.2020.08.003. Online ahead of print.
Host Polymorphisms May Impact SARS-CoV-2 Infectivity
Patrick Brest[SUP] 1 [/SUP], Sadal Refae[SUP] 2 [/SUP], Baharia Mograbi[SUP] 1 [/SUP], Paul Hofman[SUP] 3 [/SUP], Gerard Milano[SUP] 4 [/SUP]
Affiliations
- PMID: 32828550
- DOI: 10.1016/j.tig.2020.08.003
Abstract
Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected.
Keywords: SNP; coronavirus; genetic variation; infection; pharmacogenetics.