Mary Wilson
Well-known member
In Press, Corrected Proof
Available online 1 June 2022
Accepted 25 May 2022
https://doi.org/10.1016/j.jinf.2022.05.028
Joseph Heskin, Amy Belfield, Charlotte Milne, Nicklas Brown, Yasmin Walters, Christopher Scott, Margherita Bracchi, Luke SP Moore, Nabeela Mughal, Tommy Rampling, Alan Winston, Mark Nelson, Sarah Duncan, Rachael Jones, D Ashley Price, Borja Mora-Peris
... Our case involves two white British men (patients 1 and 2) who report no recent travel outside of the UK and no history of travel to regions with endemic MPX. They were both fit and well, with Patient 2 having a history of well controlled HIV on antiretroviral treatment. At the time of condomless sexual contact at the end of April 2022, Patient 1 was the receptive partner and Patient 2 the insertive partner during both anal and oro-anal sex. Of note, ten days prior to sexual contact, Patient 1 reported kissing an unrelated individual who had a crusted oral lesion.
Twenty-four hours after sexual contact, Patient 1 developed perioral white spots and painful perianal blistering lesions. Forty-eight hours later, Patient 2 had symptoms of perioral papules which blistered and ulcerated, with subsequent papules on the mons pubis and penile shaft which evolved into painful ulcers.
Neither individual reported prodromal symptoms. Skin lesions at the point of sexual contact were likely to be the herald signs of infection and (atypically) followed by systemic features of lymphadenopathy, fever, headache and diarrhoea.
... The lesions mirrored the points of skin-to-skin sexual contact with very few papules appearing outside of these anatomical sites. Both patients deteriorated and required admission to hospitals in Newcastle and London. With patient consent, communication channels were opened between the two sites to allow for information sharing, ensuring concurrent treatment. ...
https://www.sciencedirect.com/science/article/pii/S0163445322003358
Available online 1 June 2022
Accepted 25 May 2022
https://doi.org/10.1016/j.jinf.2022.05.028
Joseph Heskin, Amy Belfield, Charlotte Milne, Nicklas Brown, Yasmin Walters, Christopher Scott, Margherita Bracchi, Luke SP Moore, Nabeela Mughal, Tommy Rampling, Alan Winston, Mark Nelson, Sarah Duncan, Rachael Jones, D Ashley Price, Borja Mora-Peris
... Our case involves two white British men (patients 1 and 2) who report no recent travel outside of the UK and no history of travel to regions with endemic MPX. They were both fit and well, with Patient 2 having a history of well controlled HIV on antiretroviral treatment. At the time of condomless sexual contact at the end of April 2022, Patient 1 was the receptive partner and Patient 2 the insertive partner during both anal and oro-anal sex. Of note, ten days prior to sexual contact, Patient 1 reported kissing an unrelated individual who had a crusted oral lesion.
Twenty-four hours after sexual contact, Patient 1 developed perioral white spots and painful perianal blistering lesions. Forty-eight hours later, Patient 2 had symptoms of perioral papules which blistered and ulcerated, with subsequent papules on the mons pubis and penile shaft which evolved into painful ulcers.
Neither individual reported prodromal symptoms. Skin lesions at the point of sexual contact were likely to be the herald signs of infection and (atypically) followed by systemic features of lymphadenopathy, fever, headache and diarrhoea.
... The lesions mirrored the points of skin-to-skin sexual contact with very few papules appearing outside of these anatomical sites. Both patients deteriorated and required admission to hospitals in Newcastle and London. With patient consent, communication channels were opened between the two sites to allow for information sharing, ensuring concurrent treatment. ...
https://www.sciencedirect.com/science/article/pii/S0163445322003358