TN: Three Deaths Reported in NE Tennessee

[JimO]

Influenza hits epidemic level locally, free vaccine to be available at health departments
January 9th, 2014 7:50 pm by Sue Guinn Legg

-snip-

Mountain States Health Alliance facilities have reported three influenza-related deaths since October. Compared to past years, Dr. Anastasia Brown, lead physician for Mountains States? First Assist clinic in Kingsport said, ?unfortunately? the number is typical.

See more at: http://www.johnsoncitypress.com/art...le-at-health-departments#sthash.fSgDaBJI.dpuf

 

[NS1]

Re: TN: Three Deaths Reported in NE Tennessee

pH1N1 Genetic Sequence
Sparsity
for
Tennessee​

Only two genetic sequences are on file from Tennessee during 2013 with none after March. Those distant sequences suggest a circulation pattern similar to Texas and New Mexico.

 

[NS1]

Re: TN: Three Deaths Reported in NE Tennessee

pH1N1 Child Vaccine Escape
CDC Early 2013
​

Map - Active and Detailed
​

<div style="text-align: center;">
<hr style="width: 30%;" />41 Cases over 43 Sequences<hr style="width: 30%;" /></div>
Introduction

In the 30 days covering 2013-02-28 to 2013-03-29, the <span style="color: #783f04;"><b>United States CDC</b></span> released a total of 43 <b><span style="color: #632423; font-family: "Trebuchet MS";">pH1N1</span></b> sequences at <strong>GISAID </strong>on 41 human cases<strong> </strong>sampled from October 2012 to February 2013. Geographic surveillance includes <b>America,</b> <b>Africa, Asia </b>and<b> Russia. </b>Although <b><span style="color: #632423; font-family: "Trebuchet MS";">pH1N1</span></b> in most locales during the 2012-2013 season was the <b><span style="color: #783f04;">minority</span></b> serotype, the sequences in this Analytic Report describe a high level of human-infective diversity and an ease of avian genetic acquisition, including multiple instances demonstrating concentrated transport of <b><span style="color: #660000;">High-CFR</span></b> <b><span style="color: #632423; font-family: "Trebuchet MS";">pH1N1 </span><span style="color: #783f04;">Upsilon</span></b> polymorphisms onto single sequences.

. . .

Read the Open-Access, Full-Text
Investigational Analytic
including Genetic Details​

 

[NS1]

Re: TN: Three Deaths Reported in NE Tennessee

pH1N1 Genetic Sequence
Sparsity
for
Tennessee​

Only two genetic sequences are on file from Tennessee during 2013 with none after March. Those distant sequences suggest a circulation pattern similar to Texas and New Mexico.

pH1N1 TamiFlu Resistance
​

The most recent Tennessee sequence, sampled from a 53 year old woman in March 2013, is Drug Resistant (TmX275 onto a very common Neuraminidase) and displays CrossClade tendencies with Emergent H7N9 homology on the Hemagglutinin.

The Neuraminidase lineage is common; The CrossClade Hemagglutinin lineage was widespread to geographies supporting avian inclusions, e.g. Brazil [EPI484739] and Costa Rica [EPI484980].