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Thromboembolic events in patients with severe pandemic influenza A/H1N1

tetano

Editor, Senior Moderator
Eur J Intern Med. 2015 Sep 10. pii: S0953-6205(15)00284-8. doi: 10.1016/j.ejim.2015.08.017. [Epub ahead of print]
[h=1]Thromboembolic events in patients with severe pandemic influenza A/H1N1.[/h] Avnon LS[SUP]1[/SUP], Munteanu D[SUP]2[/SUP], Smoliakov A[SUP]3[/SUP], Jotkowitz A[SUP]4[/SUP], Barski L[SUP]5[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The 2009 pandemic influenza A/H1N1 developed as a novel swine influenza which caused more diseases among younger age groups than in the elderly. Severe hypoxemic respiratory failure from A/H1N1 pneumonia resulted in an increased need for ICU beds. Several risk groups were identified that were at a higher risk for adverse outcomes. Pregnant women were a particularly vulnerable group of patients The CDC reported on the first ten patients with severe illness and acute hypoxemic respiratory failure associated with A/H1N1 infection, none of whom were pregnant, but they noticed that half of the patients had a pulmonary embolism.
[h=4]METHODS:[/h] During a four-month period from September to December 2009, 252 patients were admitted to our hospital with confirmed pandemic influenza H1N1 by real-time reverse transcriptase-polymerase chain reaction test (rRT-PCR). We cared for twenty patients (7.9%) admitted to MICU with severe A/H1N1. Results on Thrombotic events were identified in five (25%) of our critically ill patients.
[h=4]CONCLUSIONS:[/h] We recommend that patients with severe influenza A/H1N1 pneumonitis and respiratory failure be administered DVT prophylaxis in particular if there are additional risk factors for TVE. Further prospective studies on the relationship of influenza A/H1N1 and VTE are needed.
Copyright ? 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.


[h=4]KEYWORDS:[/h] Influenza A/H1N1; Mortality; Pregnancy; Thromboembolism

PMID: 26365372 [PubMed - as supplied by publisher]
 
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