tetano
Editor, Senior Moderator
Thromb Res
. 2022 Mar 31;213:173-178.
doi: 10.1016/j.thromres.2022.03.023. Online ahead of print.
Influence of sex on development of thrombosis in patients with COVID-19: From the CLOT-COVID study
Yugo Yamashita[SUP] 1 [/SUP], Sen Yachi[SUP] 2 [/SUP], Makoto Takeyama[SUP] 2 [/SUP], Yuji Nishimoto[SUP] 3 [/SUP], Ichizo Tsujino[SUP] 4 [/SUP], Junichi Nakamura[SUP] 4 [/SUP], Naoto Yamamoto[SUP] 5 [/SUP], Hiroko Nakata[SUP] 6 [/SUP], Satoshi Ikeda[SUP] 7 [/SUP], Michihisa Umetsu[SUP] 8 [/SUP], Shizu Aikawa[SUP] 9 [/SUP], Hiroya Hayashi[SUP] 10 [/SUP], Hirono Satokawa[SUP] 11 [/SUP], Yoshinori Okuno[SUP] 12 [/SUP], Eriko Iwata[SUP] 13 [/SUP], Yoshito Ogihara[SUP] 14 [/SUP], Nobutaka Ikeda[SUP] 15 [/SUP], Akane Kondo[SUP] 16 [/SUP], Takehisa Iwai[SUP] 17 [/SUP], Norikazu Yamada[SUP] 18 [/SUP], Tomohiro Ogawa[SUP] 19 [/SUP], Takao Kobayashi[SUP] 5 [/SUP], Makoto Mo[SUP] 20 [/SUP], CLOT-COVID Study Investigators
Affiliations
Abstract
Introduction: There has been limited data on the influence of sex on development of thrombosis in patients with coronavirus disease 2019 (COVID-19).
Materials and methods: The CLOT-COVID Study was a retrospective, multicenter cohort study enrolling 2894 consecutive hospitalized patients with COVID-19 among 16 centers in Japan from April 2021 to September 2021. We divided the entire cohort into the men (N = 1885) and women (N = 1009) groups.
Results: There were no significant differences in D-dimer levels at admission between men and women. Men had more severe status of the COVID-19 at admission compared with women (Mild: 57% versus 66%, Moderate: 34% versus 29%, and Severe: 9.1% versus 5.7%, P < 0.001). Men more often received pharmacological thromboprophylaxis than women (47% versus 35%, P < 0.001). During the hospitalization, men more often developed thrombosis than women (2.5% [95%CI, 1.9-3.3%] versus 0.8% [95%CI, 0.4-1.6%], P = 0.001). Men had numerically higher incidences of thrombosis than women in all subgroups of the worst severity of COVID-19 during the hospitalization (Mild: 0.3% versus 0.0%, Moderate: 1.6% versus 1.0%, and Severe: 11.1% versus 4.3%). Even after adjusting confounders in the multivariable logistic regression model, the excess risk of men relative to women remained significant for thrombosis (adjusted OR, 2.51; 95%CI, 1.16-5.43, P = 0.02).
Conclusions: In the current large observational study of patients with COVID-19, men had more severe status of the COVID-19 than women, and the risk of development of thrombosis was higher in men compared with women, which could be helpful in determining the patient-specific optimal management strategies for COVID-19.
Keywords: COVID-19; Sex; Thrombosis.
. 2022 Mar 31;213:173-178.
doi: 10.1016/j.thromres.2022.03.023. Online ahead of print.
Influence of sex on development of thrombosis in patients with COVID-19: From the CLOT-COVID study
Yugo Yamashita[SUP] 1 [/SUP], Sen Yachi[SUP] 2 [/SUP], Makoto Takeyama[SUP] 2 [/SUP], Yuji Nishimoto[SUP] 3 [/SUP], Ichizo Tsujino[SUP] 4 [/SUP], Junichi Nakamura[SUP] 4 [/SUP], Naoto Yamamoto[SUP] 5 [/SUP], Hiroko Nakata[SUP] 6 [/SUP], Satoshi Ikeda[SUP] 7 [/SUP], Michihisa Umetsu[SUP] 8 [/SUP], Shizu Aikawa[SUP] 9 [/SUP], Hiroya Hayashi[SUP] 10 [/SUP], Hirono Satokawa[SUP] 11 [/SUP], Yoshinori Okuno[SUP] 12 [/SUP], Eriko Iwata[SUP] 13 [/SUP], Yoshito Ogihara[SUP] 14 [/SUP], Nobutaka Ikeda[SUP] 15 [/SUP], Akane Kondo[SUP] 16 [/SUP], Takehisa Iwai[SUP] 17 [/SUP], Norikazu Yamada[SUP] 18 [/SUP], Tomohiro Ogawa[SUP] 19 [/SUP], Takao Kobayashi[SUP] 5 [/SUP], Makoto Mo[SUP] 20 [/SUP], CLOT-COVID Study Investigators
Affiliations
- PMID: 35390553
- DOI: 10.1016/j.thromres.2022.03.023
Abstract
Introduction: There has been limited data on the influence of sex on development of thrombosis in patients with coronavirus disease 2019 (COVID-19).
Materials and methods: The CLOT-COVID Study was a retrospective, multicenter cohort study enrolling 2894 consecutive hospitalized patients with COVID-19 among 16 centers in Japan from April 2021 to September 2021. We divided the entire cohort into the men (N = 1885) and women (N = 1009) groups.
Results: There were no significant differences in D-dimer levels at admission between men and women. Men had more severe status of the COVID-19 at admission compared with women (Mild: 57% versus 66%, Moderate: 34% versus 29%, and Severe: 9.1% versus 5.7%, P < 0.001). Men more often received pharmacological thromboprophylaxis than women (47% versus 35%, P < 0.001). During the hospitalization, men more often developed thrombosis than women (2.5% [95%CI, 1.9-3.3%] versus 0.8% [95%CI, 0.4-1.6%], P = 0.001). Men had numerically higher incidences of thrombosis than women in all subgroups of the worst severity of COVID-19 during the hospitalization (Mild: 0.3% versus 0.0%, Moderate: 1.6% versus 1.0%, and Severe: 11.1% versus 4.3%). Even after adjusting confounders in the multivariable logistic regression model, the excess risk of men relative to women remained significant for thrombosis (adjusted OR, 2.51; 95%CI, 1.16-5.43, P = 0.02).
Conclusions: In the current large observational study of patients with COVID-19, men had more severe status of the COVID-19 than women, and the risk of development of thrombosis was higher in men compared with women, which could be helpful in determining the patient-specific optimal management strategies for COVID-19.
Keywords: COVID-19; Sex; Thrombosis.