tetano
Editor, Senior Moderator
Thorac Res Pract
. 2023 Nov 28.
doi: 10.5152/ThoracResPract.2023.23001. Online ahead of print. Recovery from Respiratory Failure in Patients with Coronavirus Disease 2019
Miraç Öz[SUP] 1 [/SUP], Serhat Erol[SUP] 1 [/SUP], Aslıhan Gürün Kaya[SUP] 1 [/SUP], Özlem Işık[SUP] 1 [/SUP], Fatma Çiftci[SUP] 1 [/SUP], Güle Çınar[SUP] 2 [/SUP], Çağlar Uzun[SUP] 3 [/SUP], Alpay Azap[SUP] 3 [/SUP], Aydın Çiledağ[SUP] 1 [/SUP], Akın Kaya[SUP] 1 [/SUP], Özlem Özdemir Kumbasar[SUP] 1 [/SUP]
Affiliations
Objective: Coronavirus disease 2019 (COVID-19) can cause hypoxic respiratory failure; long-term oxygen therapy (LTOT) duration is unknown.
Material and methods: The aim was to investigate which patients would need LTOT after COVID-19 pneumonia. This single-center, prospective study was conducted at the Ankara University Faculty of Medicine, Department of Chest Diseases, between May 2021 and December 2021. The 70 patients hospitalized for COVID-19 pneumonia and discharged with LTOT due to hypoxemic respiratory failure were included. Patients were divided into 2 groups as group I (LTOT requirement <3 months) and group II (LTOT requirement continued ≥3 months).
Results: The mean age was 64.4 ± 13.5 years, and 44 (62.9%) of them were male. The most frequently encountered comorbidities were cardiovascular disease (57.1%) and lung disease (22.9%). While PaO2 levels increased in both groups during the follow-up period, this increment was significantly higher in group I (PaO2: 66.6 ± 9.9 mm Hg, P < .001). The factors affecting the LTOT requirement were evaluated using binary logistic regression. On multivariate analyses of lymphocytes, ferritin, C-reactive protein, PaO2, SaO2, subpleural reticulation, and number of lobes affected (≥3 lobes), the SaO2 level and presence of subpleural reticulation were significantly different between the 2 groups [odds ratio (OR) (95% CI): 0.853 (0.749-0.971), P = .016] and [OR (95% CI): 0.171 (0.042-0.733), P = .017], respectively.
Conclusion: A significant proportion of patients who develop respiratory failure due to COVID-19 recover within the first 3 months. Factors determining the LTOT requirement for more than 3 months were SaO2 and the presence of subpleural reticulation.
. 2023 Nov 28.
doi: 10.5152/ThoracResPract.2023.23001. Online ahead of print. Recovery from Respiratory Failure in Patients with Coronavirus Disease 2019
Miraç Öz[SUP] 1 [/SUP], Serhat Erol[SUP] 1 [/SUP], Aslıhan Gürün Kaya[SUP] 1 [/SUP], Özlem Işık[SUP] 1 [/SUP], Fatma Çiftci[SUP] 1 [/SUP], Güle Çınar[SUP] 2 [/SUP], Çağlar Uzun[SUP] 3 [/SUP], Alpay Azap[SUP] 3 [/SUP], Aydın Çiledağ[SUP] 1 [/SUP], Akın Kaya[SUP] 1 [/SUP], Özlem Özdemir Kumbasar[SUP] 1 [/SUP]
Affiliations
- PMID: 38015163
- DOI: 10.5152/ThoracResPract.2023.23001
Objective: Coronavirus disease 2019 (COVID-19) can cause hypoxic respiratory failure; long-term oxygen therapy (LTOT) duration is unknown.
Material and methods: The aim was to investigate which patients would need LTOT after COVID-19 pneumonia. This single-center, prospective study was conducted at the Ankara University Faculty of Medicine, Department of Chest Diseases, between May 2021 and December 2021. The 70 patients hospitalized for COVID-19 pneumonia and discharged with LTOT due to hypoxemic respiratory failure were included. Patients were divided into 2 groups as group I (LTOT requirement <3 months) and group II (LTOT requirement continued ≥3 months).
Results: The mean age was 64.4 ± 13.5 years, and 44 (62.9%) of them were male. The most frequently encountered comorbidities were cardiovascular disease (57.1%) and lung disease (22.9%). While PaO2 levels increased in both groups during the follow-up period, this increment was significantly higher in group I (PaO2: 66.6 ± 9.9 mm Hg, P < .001). The factors affecting the LTOT requirement were evaluated using binary logistic regression. On multivariate analyses of lymphocytes, ferritin, C-reactive protein, PaO2, SaO2, subpleural reticulation, and number of lobes affected (≥3 lobes), the SaO2 level and presence of subpleural reticulation were significantly different between the 2 groups [odds ratio (OR) (95% CI): 0.853 (0.749-0.971), P = .016] and [OR (95% CI): 0.171 (0.042-0.733), P = .017], respectively.
Conclusion: A significant proportion of patients who develop respiratory failure due to COVID-19 recover within the first 3 months. Factors determining the LTOT requirement for more than 3 months were SaO2 and the presence of subpleural reticulation.