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http://impreso.milenio.com/node/9030070
Spanish to English translation
Research published in the journal Blood
They've found a way to "disarm" the AIDS virus
09/21/2011 ? Trends
A group of scientists found a way to prevent HIV damages the immune system and experts say their discovery may offer a new strategy for drug development.
Researchers from the U.S. and Europe working in laboratories with HIV found it is unable to damage the immune system if it removes cholesterol from the virus membrane.
"It's like an army that has lost their arms but still have flags, so you can recognize and attack," said Adriano Boasso, from Imperial College London, who led the study.
The team now plans to investigate how to use this form to deactivate the virus and possibly use it to make a vaccine.
Usually, when a person is infected with HIV, the body's immune response triggers a defense. But some researchers believe that HIV causes the system to overreact. This weakens the next line of defense, known as adaptive immune response.
For this study, published Monday in the journal Blood , Boasso team removes cholesterol from the membrane surrounding the virus and found that it stopped activating the innate immune response.
This, in turn, led to a stronger adaptive response, orchestrated by a type of antibodies called T cells
Experts in the world for years trying to develop a vaccine against HIV, but have had only limited success.
Boasso said that "HIV is very elusive, evade host defenses causing exaggerated responses that damage the immune system. This is like riding in the car in first for a long time, the engine melted. "
HIV is its membrane with that of the cell it infects, the researchers said the study. This membrane contains cholesterol, which helps to keep liquid and lets you interact with particular types of cells.
The study also included experts from Johns Hopkins universities, Milan and Innsbruck.
London / Reuters
Spanish to English translation
Research published in the journal Blood
They've found a way to "disarm" the AIDS virus
09/21/2011 ? Trends
A group of scientists found a way to prevent HIV damages the immune system and experts say their discovery may offer a new strategy for drug development.
Researchers from the U.S. and Europe working in laboratories with HIV found it is unable to damage the immune system if it removes cholesterol from the virus membrane.
"It's like an army that has lost their arms but still have flags, so you can recognize and attack," said Adriano Boasso, from Imperial College London, who led the study.
The team now plans to investigate how to use this form to deactivate the virus and possibly use it to make a vaccine.
Usually, when a person is infected with HIV, the body's immune response triggers a defense. But some researchers believe that HIV causes the system to overreact. This weakens the next line of defense, known as adaptive immune response.
For this study, published Monday in the journal Blood , Boasso team removes cholesterol from the membrane surrounding the virus and found that it stopped activating the innate immune response.
This, in turn, led to a stronger adaptive response, orchestrated by a type of antibodies called T cells
Experts in the world for years trying to develop a vaccine against HIV, but have had only limited success.
Boasso said that "HIV is very elusive, evade host defenses causing exaggerated responses that damage the immune system. This is like riding in the car in first for a long time, the engine melted. "
HIV is its membrane with that of the cell it infects, the researchers said the study. This membrane contains cholesterol, which helps to keep liquid and lets you interact with particular types of cells.
The study also included experts from Johns Hopkins universities, Milan and Innsbruck.
London / Reuters