tetano
Editor, Senior Moderator
Open Forum Infect Dis. 2019 Mar 7;6(4)
fz106. doi: 10.1093/ofid/ofz106. eCollection 2019 Apr.
[h=1]Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease.[/h] Washburn ML[SUP]1[/SUP], Crosby R[SUP]2[/SUP], Remlinger K[SUP]2[/SUP], Wang F[SUP]1[/SUP], Creech D[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Mice were infected with influenza and treated with a CXCR2 antagonist in combination with antiviral or antiviral alone starting 4 days postinfection. Neutrophil recruitment to the lung was reduced, and improvements in health outcomes and lung consolidation were observed in combination-treated mice with no evidence of worsening outcome.
[h=4]KEYWORDS:[/h] CXCR2 antagonist; biomarker; influenza; neutrophils
PMID: 31041337 PMCID: PMC6483135 DOI: 10.1093/ofid/ofz106
fz106. doi: 10.1093/ofid/ofz106. eCollection 2019 Apr.[h=1]Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease.[/h] Washburn ML[SUP]1[/SUP], Crosby R[SUP]2[/SUP], Remlinger K[SUP]2[/SUP], Wang F[SUP]1[/SUP], Creech D[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Mice were infected with influenza and treated with a CXCR2 antagonist in combination with antiviral or antiviral alone starting 4 days postinfection. Neutrophil recruitment to the lung was reduced, and improvements in health outcomes and lung consolidation were observed in combination-treated mice with no evidence of worsening outcome.
[h=4]KEYWORDS:[/h] CXCR2 antagonist; biomarker; influenza; neutrophils
PMID: 31041337 PMCID: PMC6483135 DOI: 10.1093/ofid/ofz106