tetano
Editor, Senior Moderator
Ther Apher Dial
. 2024 Feb 22.
doi: 10.1111/1744-9987.14114. Online ahead of print. Changes in antibody titer after four and five doses of the SARS-CoV-2 vaccine in Japanese post-kidney transplant patients
Kumiko Fujieda[SUP] 1 [/SUP], Akihito Tanaka[SUP] 1 [/SUP], Ryosuke Kikuchi[SUP] 2 3 [/SUP], Nami Takai[SUP] 4 [/SUP], Shoji Saito[SUP] 1 [/SUP], Yoshinari Yasuda[SUP] 1 [/SUP], Yuta Sano[SUP] 5 [/SUP], Masashi Kato[SUP] 5 [/SUP], Kazuhiro Furuhashi[SUP] 1 [/SUP], Shoichi Maruyama[SUP] 6 [/SUP]
Affiliations
Introduction: Immunosuppressed patients exhibit low antibody acquisition rates following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Kidney transplant recipients previously exhibited low antibody acquisition rates after two vaccine doses, which increased after the third dose. We evaluated antibody titers of Japanese post-kidney transplant patients after the fourth and fifth vaccinations.
Methods: Antibody titers for SARS-CoV-2 spike protein were measured between 3 weeks and 3 months after the fourth or fifth vaccination.
Results: Increased antibody acquisition rates were observed after the fourth (75.0% antibody-positive) and fifth (81.5% antibody-positive) vaccinations. The antibody-acquired group after the fourth vaccination exhibited a higher body mass index and estimated glomerular filtration rate (eGFR) than the non-acquired group. A higher eGFR was associated with antibody acquisition after the fifth vaccination.
Conclusion: In Japanese post-kidney transplant patients, the antibody acquisition rate increased with each vaccine additional dose. Additional vaccinations are recommended to protect against SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; antibody acquisition rate; immunocompromised; kidney transplantation; vaccination.
. 2024 Feb 22.
doi: 10.1111/1744-9987.14114. Online ahead of print. Changes in antibody titer after four and five doses of the SARS-CoV-2 vaccine in Japanese post-kidney transplant patients
Kumiko Fujieda[SUP] 1 [/SUP], Akihito Tanaka[SUP] 1 [/SUP], Ryosuke Kikuchi[SUP] 2 3 [/SUP], Nami Takai[SUP] 4 [/SUP], Shoji Saito[SUP] 1 [/SUP], Yoshinari Yasuda[SUP] 1 [/SUP], Yuta Sano[SUP] 5 [/SUP], Masashi Kato[SUP] 5 [/SUP], Kazuhiro Furuhashi[SUP] 1 [/SUP], Shoichi Maruyama[SUP] 6 [/SUP]
Affiliations
- PMID: 38385762
- DOI: 10.1111/1744-9987.14114
Introduction: Immunosuppressed patients exhibit low antibody acquisition rates following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Kidney transplant recipients previously exhibited low antibody acquisition rates after two vaccine doses, which increased after the third dose. We evaluated antibody titers of Japanese post-kidney transplant patients after the fourth and fifth vaccinations.
Methods: Antibody titers for SARS-CoV-2 spike protein were measured between 3 weeks and 3 months after the fourth or fifth vaccination.
Results: Increased antibody acquisition rates were observed after the fourth (75.0% antibody-positive) and fifth (81.5% antibody-positive) vaccinations. The antibody-acquired group after the fourth vaccination exhibited a higher body mass index and estimated glomerular filtration rate (eGFR) than the non-acquired group. A higher eGFR was associated with antibody acquisition after the fifth vaccination.
Conclusion: In Japanese post-kidney transplant patients, the antibody acquisition rate increased with each vaccine additional dose. Additional vaccinations are recommended to protect against SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; antibody acquisition rate; immunocompromised; kidney transplantation; vaccination.