tetano
Editor, Senior Moderator
Nat Rev Microbiol. 2014 Sep 29. doi: 10.1038/nrmicro3346. [Epub ahead of print]
The sweet spot: defining virus-sialic acid interactions.
Stencel-Baerenwald JE1, Reiss K2, Reiter DM3, Stehle T4, Dermody TS5.
Author information
Abstract
Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus-glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications.
PMID:
25263223
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25263223
The sweet spot: defining virus-sialic acid interactions.
Stencel-Baerenwald JE1, Reiss K2, Reiter DM3, Stehle T4, Dermody TS5.
Author information
Abstract
Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus-glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications.
PMID:
25263223
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25263223