tetano
Editor, Senior Moderator
Curr Opin Virol. 2012 Mar 23. [Epub ahead of print]
The role of receptor binding specificity in interspecies transmission of influenza viruses.
Imai M, Kawaoka Y.
Source
Influenza Virus Research Center, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo 208-0011, Japan.
Abstract
Influenza A virus infection begins with the binding of the hemagglutinin (HA) glycoprotein to sialic acid-containing receptors on the surface of the target cell. Avian influenza viruses, including avian H5N1, H7, and H9N2 viruses, can occasionally cross the species barrier and infect humans; however, these viruses do not spread efficiently from person to person, perhaps, partly, owing to differences in the receptor-binding specificities of human and avian influenza viruses. The HAs of avian influenza viruses must adapt to receptors in humans to acquire efficient human-to-human transmissibility. In this review, we discuss the receptor binding specificity of influenza A viruses and its role in interspecies transmission.
Copyright ? 2012. Published by Elsevier B.V.
PMID:
22445963
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22445963
The role of receptor binding specificity in interspecies transmission of influenza viruses.
Imai M, Kawaoka Y.
Source
Influenza Virus Research Center, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo 208-0011, Japan.
Abstract
Influenza A virus infection begins with the binding of the hemagglutinin (HA) glycoprotein to sialic acid-containing receptors on the surface of the target cell. Avian influenza viruses, including avian H5N1, H7, and H9N2 viruses, can occasionally cross the species barrier and infect humans; however, these viruses do not spread efficiently from person to person, perhaps, partly, owing to differences in the receptor-binding specificities of human and avian influenza viruses. The HAs of avian influenza viruses must adapt to receptors in humans to acquire efficient human-to-human transmissibility. In this review, we discuss the receptor binding specificity of influenza A viruses and its role in interspecies transmission.
Copyright ? 2012. Published by Elsevier B.V.
PMID:
22445963
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22445963