tetano
Editor, Senior Moderator
J Virol. 2012 Jul 11. [Epub ahead of print]
The NS1 protein of influenza A virus blocks RIG-I mediated activation of the noncanonical NF-κB pathway and p52/RelB dependent gene expression in lung epithelial cells.
R?ckle A, Haasbach E, Julkunen I, Planz O, Ehrhardt C, Ludwig S.
Source
Institute of Molecular Virology (IMV), Centre for Molecular Biology of Inflammation (ZMBE), Westf?lische-Wilhelms-University, Von-Esmarch-Str. 56, 48149 Muenster, Germany.
Abstract
Influenza A virus (IAV) infection of epithelial cells activates NF-κB transcription factors via the canonical NF-κB signaling pathway which modulates both, the antiviral immune response and viral replication. Since almost nothing is known so far about a function of noncanonical NF-κB signaling after IAV infection, we tested infected cells for activation of p52 and RelB. We show that the viral NS1 strongly inhibits RIG-I-mediated noncanonical NF-κB activation and expression of the noncanonical target gene CCL19.
PMID:
22787206
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22787206
The NS1 protein of influenza A virus blocks RIG-I mediated activation of the noncanonical NF-κB pathway and p52/RelB dependent gene expression in lung epithelial cells.
R?ckle A, Haasbach E, Julkunen I, Planz O, Ehrhardt C, Ludwig S.
Source
Institute of Molecular Virology (IMV), Centre for Molecular Biology of Inflammation (ZMBE), Westf?lische-Wilhelms-University, Von-Esmarch-Str. 56, 48149 Muenster, Germany.
Abstract
Influenza A virus (IAV) infection of epithelial cells activates NF-κB transcription factors via the canonical NF-κB signaling pathway which modulates both, the antiviral immune response and viral replication. Since almost nothing is known so far about a function of noncanonical NF-κB signaling after IAV infection, we tested infected cells for activation of p52 and RelB. We show that the viral NS1 strongly inhibits RIG-I-mediated noncanonical NF-κB activation and expression of the noncanonical target gene CCL19.
PMID:
22787206
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22787206