tetano
Editor, Senior Moderator
Biochemistry. 2015 May 21. [Epub ahead of print]
[h=1]The Influenza A PB1-F2 & N40 Start Codons are Contained Within an RNA Pseudoknot.[/h] Priore SF, Kauffmann AD, Baman JR, Turner DH.
[h=3]Abstract[/h] Influenza A is a negative-sense RNA virus with an eight-segment genome. Some segments code for more than one polypeptide product, but how the virus accesses alternate internal open reading frames (ORFs) is not completely understood. In segment 2, ribosomal scanning produces two internal ORFs, PB1-F2 and N40. Here, chemical mapping reveals a Mg2+ dependent pseudoknot structure that includes the PB1-F2 and N40 start codons. The results suggest that ribosome interactions with the pseudoknot may affect the level of translation for PB1-F2 and N40.
PMID: 25996464 [PubMed - as supplied by publisher]
[h=1]The Influenza A PB1-F2 & N40 Start Codons are Contained Within an RNA Pseudoknot.[/h] Priore SF, Kauffmann AD, Baman JR, Turner DH.
[h=3]Abstract[/h] Influenza A is a negative-sense RNA virus with an eight-segment genome. Some segments code for more than one polypeptide product, but how the virus accesses alternate internal open reading frames (ORFs) is not completely understood. In segment 2, ribosomal scanning produces two internal ORFs, PB1-F2 and N40. Here, chemical mapping reveals a Mg2+ dependent pseudoknot structure that includes the PB1-F2 and N40 start codons. The results suggest that ribosome interactions with the pseudoknot may affect the level of translation for PB1-F2 and N40.
PMID: 25996464 [PubMed - as supplied by publisher]