tetano
Editor, Senior Moderator
Pathogens. 2019 Nov 26;8(4). pii: E265. doi: 10.3390/pathogens8040265. [h=1]The Importance of Vaccinating Children and Pregnant Women against Influenza Virus Infection.[/h]
Misra RS[SUP]1[/SUP], Nayak JL[SUP]2[/SUP].
[h=3]Author information[/h] 1 Department of Pediatrics Division of Neonatology, The University of Rochester Medical Center, Rochester, NY 14623, USA. 2 Department of Pediatrics Division of Pediatric Infectious Diseases, The University of Rochester Medical Center, Rochester, NY 14623, USA.
[h=3]Abstract[/h] Influenza virus infection is responsible for significant morbidity and mortality in the pediatric and pregnant women populations, with deaths frequently caused by severe influenza-associated lower respiratory tract infection and acute respiratory distress syndrome (ARDS). An appropriate immune response requires controlling the viral infection through activation of antiviral defenses, which involves cells of the lung and immune system. High levels of viral infection or high levels of inflammation in the lower airways can contribute to ARDS. Pregnant women and young children, especially those born prematurely, may develop serious complications if infected with influenza virus. Vaccination against influenza will lead to lower infection rates and fewer complications, even if the vaccine is poorly matched to circulating viral strains, with maternal vaccination offering infants protection via antibody transmission through the placenta and breast milk. Despite the health benefits of the influenza vaccine, vaccination rates around the world remain well below targets. Trust in the use of vaccines among the public must be restored in order to increase vaccination rates and decrease the public health burden of influenza.
[h=4]KEYWORDS:[/h] ARDS; influenza virus; lung; morbidity; pediatrics; pregnant women; vaccination rate; vaccines
PMID: 31779153 DOI: 10.3390/pathogens8040265
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Misra RS[SUP]1[/SUP], Nayak JL[SUP]2[/SUP].
[h=3]Author information[/h] 1 Department of Pediatrics Division of Neonatology, The University of Rochester Medical Center, Rochester, NY 14623, USA. 2 Department of Pediatrics Division of Pediatric Infectious Diseases, The University of Rochester Medical Center, Rochester, NY 14623, USA.
[h=3]Abstract[/h] Influenza virus infection is responsible for significant morbidity and mortality in the pediatric and pregnant women populations, with deaths frequently caused by severe influenza-associated lower respiratory tract infection and acute respiratory distress syndrome (ARDS). An appropriate immune response requires controlling the viral infection through activation of antiviral defenses, which involves cells of the lung and immune system. High levels of viral infection or high levels of inflammation in the lower airways can contribute to ARDS. Pregnant women and young children, especially those born prematurely, may develop serious complications if infected with influenza virus. Vaccination against influenza will lead to lower infection rates and fewer complications, even if the vaccine is poorly matched to circulating viral strains, with maternal vaccination offering infants protection via antibody transmission through the placenta and breast milk. Despite the health benefits of the influenza vaccine, vaccination rates around the world remain well below targets. Trust in the use of vaccines among the public must be restored in order to increase vaccination rates and decrease the public health burden of influenza.
[h=4]KEYWORDS:[/h] ARDS; influenza virus; lung; morbidity; pediatrics; pregnant women; vaccination rate; vaccines
PMID: 31779153 DOI: 10.3390/pathogens8040265
Free full text