tetano
Editor, Senior Moderator
Antimicrob Agents Chemother. 2015 Jul 27. pii: AAC.01098-15. [Epub ahead of print]
[h=1]The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Infection.[/h] Traboulsi H[SUP]1[/SUP], Cloutier A[SUP]2[/SUP], Boyapelly K[SUP]3[/SUP], Bonin MA[SUP]3[/SUP], Marsault ?[SUP]3[/SUP], Cantin AM[SUP]2[/SUP], Richter MV[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The host response to influenza virus infection is characterized by an acute lung inflammatory response in which intense inflammatory cell recruitment, hypercytokinemia, and high level of oxidative stress are present. The sum of these events contributes to the virus-induced lung damage that leads to high a level of morbidity and mortality in susceptible infected patients. In this context, we identified compounds that can simultaneously reduce the excessive inflammatory response and the viral replication as a strategy to treat influenza infection. We investigated the anti-inflammatory and antiviral potential activities of isoliquiritigenin (ILG). Interestingly, we demonstrated that ILG is a potent inhibitor of influenza virus replication in human bronchial epithelial cells (EC[SUB]50[/SUB]= 24.7μM). In addition, our results showed that this molecule inhibits the expression of inflammatory cytokines induced after the infection of cells with the influenza virus. We demonstrated that the anti-inflammatory activity of ILG in the context of influenza infection is dependent on the activation of the peroxisome proliferator-activated receptor gamma pathway. Interestingly, ILG-phosphate (ILG-p)-treated mice displayed decreased lung inflammation as depicted by reduced cytokine gene expression and inflammatory cell recruitment. We also demonstrated that influenza-specific CD8[SUP]+[/SUP] effector T cell recruitment was reduced up to 60% in the lungs of mice treated with ILG-p (10 mg/kg) compared to saline-treated mice. Finally, we showed that administration of ILG-p reduced lung viral titers and morbidity of mice infected with the PR8/H1N1 virus.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26248373 [PubMed - as supplied by publisher]
[h=1]The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Infection.[/h] Traboulsi H[SUP]1[/SUP], Cloutier A[SUP]2[/SUP], Boyapelly K[SUP]3[/SUP], Bonin MA[SUP]3[/SUP], Marsault ?[SUP]3[/SUP], Cantin AM[SUP]2[/SUP], Richter MV[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The host response to influenza virus infection is characterized by an acute lung inflammatory response in which intense inflammatory cell recruitment, hypercytokinemia, and high level of oxidative stress are present. The sum of these events contributes to the virus-induced lung damage that leads to high a level of morbidity and mortality in susceptible infected patients. In this context, we identified compounds that can simultaneously reduce the excessive inflammatory response and the viral replication as a strategy to treat influenza infection. We investigated the anti-inflammatory and antiviral potential activities of isoliquiritigenin (ILG). Interestingly, we demonstrated that ILG is a potent inhibitor of influenza virus replication in human bronchial epithelial cells (EC[SUB]50[/SUB]= 24.7μM). In addition, our results showed that this molecule inhibits the expression of inflammatory cytokines induced after the infection of cells with the influenza virus. We demonstrated that the anti-inflammatory activity of ILG in the context of influenza infection is dependent on the activation of the peroxisome proliferator-activated receptor gamma pathway. Interestingly, ILG-phosphate (ILG-p)-treated mice displayed decreased lung inflammation as depicted by reduced cytokine gene expression and inflammatory cell recruitment. We also demonstrated that influenza-specific CD8[SUP]+[/SUP] effector T cell recruitment was reduced up to 60% in the lungs of mice treated with ILG-p (10 mg/kg) compared to saline-treated mice. Finally, we showed that administration of ILG-p reduced lung viral titers and morbidity of mice infected with the PR8/H1N1 virus.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26248373 [PubMed - as supplied by publisher]