tetano
Editor, Senior Moderator
J Virol. 2011 Sep 14. [Epub ahead of print]
The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses.
Pica N, Iyer A, Ramos I, Bouvier NM, Fernandez-Sesma A, Garc?a-Sastre A, Lowen AC, Palese P, Steel J.
Source
Department of Microbiology.
Abstract
We assess the relative susceptibility to disease of the DBA.2 and C57BL/6 mouse models upon infection with a range of influenza A and B viruses. DBA.2 mice were more susceptible to disease upon inoculation with human H1N1 influenza A strains, several swine influenza viruses, and influenza B viruses but were not overtly susceptible to infection with human seasonal H3N2 strains. Hemagglutination inhibition and immunoglobulin isotype profiling indicated that DBA.2 and C57BL/6 mice generate comparable humoral responses upon equivalent MLD(50) challenges with influenza virus. Our data demonstrate the utility of DBA.2 mice for the elucidation of influenza virus pathogenicity determinants and the testing of influenza vaccines.
PMID:
21917963
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21917963
The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses.
Pica N, Iyer A, Ramos I, Bouvier NM, Fernandez-Sesma A, Garc?a-Sastre A, Lowen AC, Palese P, Steel J.
Source
Department of Microbiology.
Abstract
We assess the relative susceptibility to disease of the DBA.2 and C57BL/6 mouse models upon infection with a range of influenza A and B viruses. DBA.2 mice were more susceptible to disease upon inoculation with human H1N1 influenza A strains, several swine influenza viruses, and influenza B viruses but were not overtly susceptible to infection with human seasonal H3N2 strains. Hemagglutination inhibition and immunoglobulin isotype profiling indicated that DBA.2 and C57BL/6 mice generate comparable humoral responses upon equivalent MLD(50) challenges with influenza virus. Our data demonstrate the utility of DBA.2 mice for the elucidation of influenza virus pathogenicity determinants and the testing of influenza vaccines.
PMID:
21917963
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21917963