tetano
Editor, Senior Moderator
Heart Rhythm. 2016 Feb 2. pii: S1547-5271(16)00126-0. doi: 10.1016/j.hrthm.2016.01.026. [Epub ahead of print]
[h=1]The Association between Influenza Infection, Vaccination and Atrial Fibrillation: A Nationwide Case-Control Study.[/h] Chang TY[SUP]1[/SUP], Chao TF[SUP]2[/SUP], Liu CJ[SUP]3[/SUP], Jung CS[SUP]4[/SUP], Chung FP[SUP]1[/SUP], Liao JN[SUP]1[/SUP], Tuan TC[SUP]5[/SUP], Chen TJ[SUP]6[/SUP], Chen SA[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza infection could activate systemic inflammatory responses and increase the sympathetic tone which play an important role in the pathogenesis of atrial fibrillation (AF).
[h=4]OBJECTIVE:[/h] The goal of the present study was to investigate whether influenza infection was a risk factor of AF. We also aimed to study whether influenza vaccination could decrease the AF risk.
[h=4]METHODS:[/h] From 2000-2010, a total of 11,374 patients with newly diagnosed AF were identified from the Taiwan National Health Insurance Research Database. On the same date of enrollment, 4 control patients (without AF) with matched age and sex were selected to be the control group for each study patient. The relationship between AF and influenza infection/ vaccination 1 year before the enrollment was analyzed.
[h=4]RESULTS:[/h] Compared to patients without influenza infection nor vaccination (reference group, n=38,353), patients with influenza infection without vaccination (n=1,369) were associated with a significant higher risk of AF with an odds ratio of 1.182 (p=0.032) after the adjustment for baseline differences. The risk of AF was lower among patients receiving influenza vaccination without influenza infection (n=16,452) with an odds ratio of 0.881 (p<0.001). For patients who have received influenza vaccination and experienced influenza infection (n=696), the risk of AF was similar to that of the reference group (odds ratio=1.136, p=0.214). The lower risk of AF with vaccination was consistently observed in subgroup analyses.
[h=4]CONCLUSIONS:[/h] Influenza infection was significantly associated with the development of AF, with an 18% increase in the risk, which could be reduced through influenza vaccination.
Copyright ? 2016. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] atrial fibrillation; influenza infection; vaccination
PMID: 26850784 [PubMed - as supplied by publisher]
[h=1]The Association between Influenza Infection, Vaccination and Atrial Fibrillation: A Nationwide Case-Control Study.[/h] Chang TY[SUP]1[/SUP], Chao TF[SUP]2[/SUP], Liu CJ[SUP]3[/SUP], Jung CS[SUP]4[/SUP], Chung FP[SUP]1[/SUP], Liao JN[SUP]1[/SUP], Tuan TC[SUP]5[/SUP], Chen TJ[SUP]6[/SUP], Chen SA[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza infection could activate systemic inflammatory responses and increase the sympathetic tone which play an important role in the pathogenesis of atrial fibrillation (AF).
[h=4]OBJECTIVE:[/h] The goal of the present study was to investigate whether influenza infection was a risk factor of AF. We also aimed to study whether influenza vaccination could decrease the AF risk.
[h=4]METHODS:[/h] From 2000-2010, a total of 11,374 patients with newly diagnosed AF were identified from the Taiwan National Health Insurance Research Database. On the same date of enrollment, 4 control patients (without AF) with matched age and sex were selected to be the control group for each study patient. The relationship between AF and influenza infection/ vaccination 1 year before the enrollment was analyzed.
[h=4]RESULTS:[/h] Compared to patients without influenza infection nor vaccination (reference group, n=38,353), patients with influenza infection without vaccination (n=1,369) were associated with a significant higher risk of AF with an odds ratio of 1.182 (p=0.032) after the adjustment for baseline differences. The risk of AF was lower among patients receiving influenza vaccination without influenza infection (n=16,452) with an odds ratio of 0.881 (p<0.001). For patients who have received influenza vaccination and experienced influenza infection (n=696), the risk of AF was similar to that of the reference group (odds ratio=1.136, p=0.214). The lower risk of AF with vaccination was consistently observed in subgroup analyses.
[h=4]CONCLUSIONS:[/h] Influenza infection was significantly associated with the development of AF, with an 18% increase in the risk, which could be reduced through influenza vaccination.
Copyright ? 2016. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] atrial fibrillation; influenza infection; vaccination
PMID: 26850784 [PubMed - as supplied by publisher]