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Editor, Senior Moderator
Vaccine
Volume 29, Supplement 2, 22 July 2011, Pages B21-B26
Historical Influenza Pandemics
doi:10.1016/j.vaccine.2011.02.048 | How to Cite or Link Using DOI
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The 1918?1920 influenza pandemic in Peru
G. Chowella, b, Corresponding Author Contact Information, E-mail The Corresponding Author, C. Viboudb, L. Simonsenb, c, M.A. Millera, J. Hurtadod, G. Sotod, R. Vargase, M.A. Guzmanf, M. Ulload and C.V. Munaycod
a Mathematical, Computational & Modeling Sciences Center, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA
b Division of Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA
c Department of Global Health, School of Public Health and Health Services, George Washington University, Washington, DC, USA
d Direcci?n General de Epidemiolog?a, Per? Ministerio de Salud, Lima, Peru
e Hospital Bel?n, Direcci?n Regional de Salud, La Libertad, Peru
f Universidad Nacional de la Amazon?a Peruana, Peru
Received 30 October 2010;
revised 13 January 2011;
accepted 15 February 2011.
Available online 12 July 2011.
Abstract
Background
Increasing our knowledge of past influenza pandemic patterns in different regions of the world is crucial to guide preparedness plans against future influenza pandemics. Here, we undertook extensive archival collection efforts from three representative cities of Peru?Lima in the central coast, Iquitos in the northeastern Amazon region, Ica in the southern coast?to characterize the temporal, age and geographic patterns of the 1918?1920 influenza pandemic in this country.
Materials and methods
We analyzed historical documents describing the 1918?1920 influenza pandemic in Peru and retrieved individual mortality records from local provincial archives for quantitative analysis. We applied seasonal excess mortality models to daily and monthly respiratory mortality rates for 1917?1920 and quantified transmissibility estimates based on the daily growth rate in respiratory deaths.
Results
A total of 52,739 individual mortality records were inspected from local provincial archives. We found evidence for an initial mild pandemic wave during July?September 1918 in Lima, identified a synchronized severe pandemic wave of respiratory mortality in all three locations during November 1918?February 1919, and a severe pandemic wave during January 1920?March 1920 in Lima and July?October 1920 in Ica. There was no recrudescent pandemic wave in 1920 in Iquitos. Remarkably, Lima experienced the brunt of the 1918?1920 excess mortality impact during the 1920 recrudescent wave, with all age groups experiencing an increase in all cause excess mortality from 1918?1919 to 1920. Middle age groups experienced the highest excess mortality impact, relative to baseline levels, in the 1918?1919 and 1920 pandemic waves. Cumulative excess mortality rates for the 1918?1920 pandemic period were higher in Iquitos (2.9%) than Lima (1.6%). The mean reproduction number for Lima was estimated in the range 1.3?1.5.
Conclusions
We identified synchronized pandemic waves of intense excess respiratory mortality during November 1918?February 1919 in Lima, Iquitos, Ica, followed by asynchronous recrudescent waves in 1920. Cumulative data from quantitative studies of the 1918 influenza pandemic in Latin American settings have confirmed the high mortality impact associated with this pandemic. Further historical studies in lesser studied regions of Latin America, Africa, and Asia are warranted for a full understanding of the global impact of the 1918 pandemic virus.
http://www.sciencedirect.com/science/article/pii/S0264410X11002830
Volume 29, Supplement 2, 22 July 2011, Pages B21-B26
Historical Influenza Pandemics
doi:10.1016/j.vaccine.2011.02.048 | How to Cite or Link Using DOI
Permissions & Reprints
The 1918?1920 influenza pandemic in Peru
G. Chowella, b, Corresponding Author Contact Information, E-mail The Corresponding Author, C. Viboudb, L. Simonsenb, c, M.A. Millera, J. Hurtadod, G. Sotod, R. Vargase, M.A. Guzmanf, M. Ulload and C.V. Munaycod
a Mathematical, Computational & Modeling Sciences Center, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA
b Division of Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA
c Department of Global Health, School of Public Health and Health Services, George Washington University, Washington, DC, USA
d Direcci?n General de Epidemiolog?a, Per? Ministerio de Salud, Lima, Peru
e Hospital Bel?n, Direcci?n Regional de Salud, La Libertad, Peru
f Universidad Nacional de la Amazon?a Peruana, Peru
Received 30 October 2010;
revised 13 January 2011;
accepted 15 February 2011.
Available online 12 July 2011.
Abstract
Background
Increasing our knowledge of past influenza pandemic patterns in different regions of the world is crucial to guide preparedness plans against future influenza pandemics. Here, we undertook extensive archival collection efforts from three representative cities of Peru?Lima in the central coast, Iquitos in the northeastern Amazon region, Ica in the southern coast?to characterize the temporal, age and geographic patterns of the 1918?1920 influenza pandemic in this country.
Materials and methods
We analyzed historical documents describing the 1918?1920 influenza pandemic in Peru and retrieved individual mortality records from local provincial archives for quantitative analysis. We applied seasonal excess mortality models to daily and monthly respiratory mortality rates for 1917?1920 and quantified transmissibility estimates based on the daily growth rate in respiratory deaths.
Results
A total of 52,739 individual mortality records were inspected from local provincial archives. We found evidence for an initial mild pandemic wave during July?September 1918 in Lima, identified a synchronized severe pandemic wave of respiratory mortality in all three locations during November 1918?February 1919, and a severe pandemic wave during January 1920?March 1920 in Lima and July?October 1920 in Ica. There was no recrudescent pandemic wave in 1920 in Iquitos. Remarkably, Lima experienced the brunt of the 1918?1920 excess mortality impact during the 1920 recrudescent wave, with all age groups experiencing an increase in all cause excess mortality from 1918?1919 to 1920. Middle age groups experienced the highest excess mortality impact, relative to baseline levels, in the 1918?1919 and 1920 pandemic waves. Cumulative excess mortality rates for the 1918?1920 pandemic period were higher in Iquitos (2.9%) than Lima (1.6%). The mean reproduction number for Lima was estimated in the range 1.3?1.5.
Conclusions
We identified synchronized pandemic waves of intense excess respiratory mortality during November 1918?February 1919 in Lima, Iquitos, Ica, followed by asynchronous recrudescent waves in 1920. Cumulative data from quantitative studies of the 1918 influenza pandemic in Latin American settings have confirmed the high mortality impact associated with this pandemic. Further historical studies in lesser studied regions of Latin America, Africa, and Asia are warranted for a full understanding of the global impact of the 1918 pandemic virus.
http://www.sciencedirect.com/science/article/pii/S0264410X11002830