tetano
Editor, Senior Moderator
FEBS Lett. 2013 Mar 12. pii: S0014-5793(13)00194-4. doi: 10.1016/j.febslet.2013.02.048. [Epub ahead of print]
Structure and assembly of the influenza A virus ribonucleoprotein complex.
Zheng W, Tao YJ.
Source
Department of Biochemistry and Cell Biology, Rice University, 6100 Main Street, MS140, Houston, TX 77005, United States.
Abstract
The genome of influenza A viruses consists of eight segments of single-stranded, negative-sense RNA that are encapsidated as individual rod-shaped ribonucleoprotein complexes (RNPs). Each RNP contains a viral RNA, a viral polymerase and multiple copies of the viral nucleoprotein (NP). Influenza A virus RNPs play important roles during virus infection by directing viral RNA replication and transcription, intracellular transport of the viral RNA, gene reassortment as well as viral genome packaging into progeny particles. As a unique genomic entity, the influenza A virus RNP has been extensively studied since the 1960's. Recently, exciting progress has been made in studying the RNP structure and its assembly, leading to a better understanding of the structural basis of various RNP functions.
Copyright ? 2013. Published by Elsevier B.V.
PMID:
23499938
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23499938
Structure and assembly of the influenza A virus ribonucleoprotein complex.
Zheng W, Tao YJ.
Source
Department of Biochemistry and Cell Biology, Rice University, 6100 Main Street, MS140, Houston, TX 77005, United States.
Abstract
The genome of influenza A viruses consists of eight segments of single-stranded, negative-sense RNA that are encapsidated as individual rod-shaped ribonucleoprotein complexes (RNPs). Each RNP contains a viral RNA, a viral polymerase and multiple copies of the viral nucleoprotein (NP). Influenza A virus RNPs play important roles during virus infection by directing viral RNA replication and transcription, intracellular transport of the viral RNA, gene reassortment as well as viral genome packaging into progeny particles. As a unique genomic entity, the influenza A virus RNP has been extensively studied since the 1960's. Recently, exciting progress has been made in studying the RNP structure and its assembly, leading to a better understanding of the structural basis of various RNP functions.
Copyright ? 2013. Published by Elsevier B.V.
PMID:
23499938
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23499938